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Efficacy of fish oil supplementation for treatment of moderate elevation of serum cholesterol.
J Fam Pract. 1990 Jan; 30(1):55-9.JF

Abstract

A study was performed to determine the efficacy and feasibility of using fish oil capsules for treatment of moderate hypercholesterolemia. Thirty-three subjects, randomized to fish or olive oil, took two 1-g capsules with each meal for 12 weeks. Each subject crossed over to the alternate treatment at 12 weeks. Patients maintained usual levels of exercise and diet for 24 weeks. Eight subjects dropped out. For the group starting fish oil (n = 13), the average baseline cholesterol level was 6.336 mmol/L (245.0 mg/dL) and was 6.341 mmol/L (245.2 mg/dL) after 12 weeks. High-density lipoprotein cholesterol (HDL-C) and calculated low-density lipoprotein cholesterol (LDL-C) baseline levels were 1.459 mmol/L (56.4 mg/dL) and 4.332 mmol/L (167.5 mg/dL); 1.474 mmol/L (57.0 mg/dL) and 4.479 mmol/L (173.2 mg/dL), respectively, after fish oil supplementation. In the group that began with olive oil (n = 12), baseline total cholesterol level was 6.274 mmol/L (242.6 mg/dL); HDL-C and calculated LDL-C baseline levels were 1.386 mmol/L (53.6 mg/dL) and 3.988 mmol/L (154.2 mg/dL). When mean baseline levels were compared with post-fish-oil values for the entire population, no significant change in total cholesterol or LDL-HDL ratio was obtained. Triglyceride responses to fish oil were variable. Values after olive oil treatment were neither significantly different from baseline nor different from fish oil. It was concluded that fish oil in manufacturer's recommended dosage does not appear to lower moderately elevated cholesterol levels.

Authors+Show Affiliations

Department of Family Medicine, State University of New York, Stony Brook.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2403586

Citation

Valdini, A F., et al. "Efficacy of Fish Oil Supplementation for Treatment of Moderate Elevation of Serum Cholesterol." The Journal of Family Practice, vol. 30, no. 1, 1990, pp. 55-9.
Valdini AF, Glenn MA, Greenblatt L, et al. Efficacy of fish oil supplementation for treatment of moderate elevation of serum cholesterol. J Fam Pract. 1990;30(1):55-9.
Valdini, A. F., Glenn, M. A., Greenblatt, L., & Steinhardt, S. (1990). Efficacy of fish oil supplementation for treatment of moderate elevation of serum cholesterol. The Journal of Family Practice, 30(1), 55-9.
Valdini AF, et al. Efficacy of Fish Oil Supplementation for Treatment of Moderate Elevation of Serum Cholesterol. J Fam Pract. 1990;30(1):55-9. PubMed PMID: 2403586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of fish oil supplementation for treatment of moderate elevation of serum cholesterol. AU - Valdini,A F, AU - Glenn,M A, AU - Greenblatt,L, AU - Steinhardt,S, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 55 EP - 9 JF - The Journal of family practice JO - J Fam Pract VL - 30 IS - 1 N2 - A study was performed to determine the efficacy and feasibility of using fish oil capsules for treatment of moderate hypercholesterolemia. Thirty-three subjects, randomized to fish or olive oil, took two 1-g capsules with each meal for 12 weeks. Each subject crossed over to the alternate treatment at 12 weeks. Patients maintained usual levels of exercise and diet for 24 weeks. Eight subjects dropped out. For the group starting fish oil (n = 13), the average baseline cholesterol level was 6.336 mmol/L (245.0 mg/dL) and was 6.341 mmol/L (245.2 mg/dL) after 12 weeks. High-density lipoprotein cholesterol (HDL-C) and calculated low-density lipoprotein cholesterol (LDL-C) baseline levels were 1.459 mmol/L (56.4 mg/dL) and 4.332 mmol/L (167.5 mg/dL); 1.474 mmol/L (57.0 mg/dL) and 4.479 mmol/L (173.2 mg/dL), respectively, after fish oil supplementation. In the group that began with olive oil (n = 12), baseline total cholesterol level was 6.274 mmol/L (242.6 mg/dL); HDL-C and calculated LDL-C baseline levels were 1.386 mmol/L (53.6 mg/dL) and 3.988 mmol/L (154.2 mg/dL). When mean baseline levels were compared with post-fish-oil values for the entire population, no significant change in total cholesterol or LDL-HDL ratio was obtained. Triglyceride responses to fish oil were variable. Values after olive oil treatment were neither significantly different from baseline nor different from fish oil. It was concluded that fish oil in manufacturer's recommended dosage does not appear to lower moderately elevated cholesterol levels. SN - 0094-3509 UR - https://www.unboundmedicine.com/medline/citation/2403586/Efficacy_of_fish_oil_supplementation_for_treatment_of_moderate_elevation_of_serum_cholesterol_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -