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Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis.
Prev Med. 2013 Dec; 57(6):753-64.PM

Abstract

OBJECTIVE

To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality.

METHOD

Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L.

RESULTS

In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women. A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)). Large heterogeneity was observed for studies on total cancer mortality (P<0.01) but not for studies on cancer incidence (P=0.41). No publication bias was found.

CONCLUSION

The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24036014

Citation

Yin, Lu, et al. "Circulating 25-hydroxyvitamin D Serum Concentration and Total Cancer Incidence and Mortality: a Systematic Review and Meta-analysis." Preventive Medicine, vol. 57, no. 6, 2013, pp. 753-64.
Yin L, Ordóñez-Mena JM, Chen T, et al. Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis. Prev Med. 2013;57(6):753-64.
Yin, L., Ordóñez-Mena, J. M., Chen, T., Schöttker, B., Arndt, V., & Brenner, H. (2013). Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis. Preventive Medicine, 57(6), 753-64. https://doi.org/10.1016/j.ypmed.2013.08.026
Yin L, et al. Circulating 25-hydroxyvitamin D Serum Concentration and Total Cancer Incidence and Mortality: a Systematic Review and Meta-analysis. Prev Med. 2013;57(6):753-64. PubMed PMID: 24036014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis. AU - Yin,Lu, AU - Ordóñez-Mena,José M, AU - Chen,Tianhui, AU - Schöttker,Ben, AU - Arndt,Volker, AU - Brenner,Hermann, Y1 - 2013/09/10/ PY - 2013/03/18/received PY - 2013/08/28/revised PY - 2013/08/31/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/8/15/medline KW - Cancer KW - Incidence KW - Meta-Analysis KW - Mortality KW - Vitamin D SP - 753 EP - 64 JF - Preventive medicine JO - Prev Med VL - 57 IS - 6 N2 - OBJECTIVE: To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality. METHOD: Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L. RESULTS: In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women. A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)). Large heterogeneity was observed for studies on total cancer mortality (P<0.01) but not for studies on cancer incidence (P=0.41). No publication bias was found. CONCLUSION: The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality. SN - 1096-0260 UR - https://www.unboundmedicine.com/medline/citation/24036014/Circulating_25_hydroxyvitamin_D_serum_concentration_and_total_cancer_incidence_and_mortality:_a_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(13)00318-6 DB - PRIME DP - Unbound Medicine ER -