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Permeability and lipid organization of a novel psoriasis stratum corneum substitute.
Int J Pharm. 2013 Nov 30; 457(1):275-82.IJ

Abstract

Lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier properties. The main lipid classes are ceramides, cholesterol and free fatty acids. In previous studies a stratum corneum substitute (SCS) was developed, solely prepared from the SC lipids. The SCS mimics the lipid barrier properties of SC very closely. The present study aimed to design a psoriasis SCS (PS-SCS) mimicking several aspects of the lipid composition in SC from psoriasis patients. This PS-SCS showed a different lipid organization than SCS. The main differences were a reduced presence of an orthorhombic packing and an increased level of crystalline cholesterol. These changes resulted in lower flux of hydrocortisone across PS-SCS than across SCS and SC, which was most likely attributed to the higher level of phase separated crystalline cholesterol in PS-SCS. As propylene glycol (PG) is often used in dermatological formulations, in subsequent studies the interaction of PG with SC and SCS membranes was also investigated. These studies revealed that PG increased the permeability of hydrocortisone, mainly by selectively extracting cholesterol from SCS membranes and SC. This may play an important role in the penetration enhancing effect of PG.

Authors+Show Affiliations

LEO Pharma, Department of DMPK and Safety, Industriparken 55, 2750 Ballerup, Denmark; Leiden/Amsterdam Center for Drug Research (LACDR), Department of Drug Delivery Technology, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. Electronic address: line.basse@leo-pharma.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24036087

Citation

Basse, Line Hollesen, et al. "Permeability and Lipid Organization of a Novel Psoriasis Stratum Corneum Substitute." International Journal of Pharmaceutics, vol. 457, no. 1, 2013, pp. 275-82.
Basse LH, Groen D, Bouwstra JA. Permeability and lipid organization of a novel psoriasis stratum corneum substitute. Int J Pharm. 2013;457(1):275-82.
Basse, L. H., Groen, D., & Bouwstra, J. A. (2013). Permeability and lipid organization of a novel psoriasis stratum corneum substitute. International Journal of Pharmaceutics, 457(1), 275-82. https://doi.org/10.1016/j.ijpharm.2013.08.086
Basse LH, Groen D, Bouwstra JA. Permeability and Lipid Organization of a Novel Psoriasis Stratum Corneum Substitute. Int J Pharm. 2013 Nov 30;457(1):275-82. PubMed PMID: 24036087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Permeability and lipid organization of a novel psoriasis stratum corneum substitute. AU - Basse,Line Hollesen, AU - Groen,Daniël, AU - Bouwstra,Joke A, Y1 - 2013/09/10/ PY - 2013/06/19/received PY - 2013/08/27/revised PY - 2013/08/28/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/6/27/medline KW - 6-hydroxysphingosine KW - A KW - Barrier function KW - CER KW - CHOL KW - Dermal drug delivery KW - Diseased skin KW - EO KW - FFA KW - FTIR KW - Fourier transform infrared spectroscopy KW - H KW - LPP KW - N KW - P KW - PG KW - PS-SCS KW - Propylene glycol KW - S KW - SAXD KW - SCS KW - SPP KW - Skin KW - Stratum corneum lipids KW - ceramides KW - cholesterol KW - dS KW - dihydroxysphingosine KW - free fatty acids KW - long periodicity phase KW - non-hydroxy KW - phytosphingosine KW - propylene glycol KW - psoriasis stratum corneum substitute KW - short periodicity phase KW - small angle X-ray diffraction KW - sphingosine KW - stratum corneum substitute KW - α-hydroxy KW - ω-hydroxy SP - 275 EP - 82 JF - International journal of pharmaceutics JO - Int J Pharm VL - 457 IS - 1 N2 - Lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier properties. The main lipid classes are ceramides, cholesterol and free fatty acids. In previous studies a stratum corneum substitute (SCS) was developed, solely prepared from the SC lipids. The SCS mimics the lipid barrier properties of SC very closely. The present study aimed to design a psoriasis SCS (PS-SCS) mimicking several aspects of the lipid composition in SC from psoriasis patients. This PS-SCS showed a different lipid organization than SCS. The main differences were a reduced presence of an orthorhombic packing and an increased level of crystalline cholesterol. These changes resulted in lower flux of hydrocortisone across PS-SCS than across SCS and SC, which was most likely attributed to the higher level of phase separated crystalline cholesterol in PS-SCS. As propylene glycol (PG) is often used in dermatological formulations, in subsequent studies the interaction of PG with SC and SCS membranes was also investigated. These studies revealed that PG increased the permeability of hydrocortisone, mainly by selectively extracting cholesterol from SCS membranes and SC. This may play an important role in the penetration enhancing effect of PG. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/24036087/Permeability_and_lipid_organization_of_a_novel_psoriasis_stratum_corneum_substitute_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(13)00820-X DB - PRIME DP - Unbound Medicine ER -