Tags

Type your tag names separated by a space and hit enter

Physiological role of hydrogen sulfide and polysulfide in the central nervous system.
Neurochem Int. 2013 Nov; 63(5):492-7.NI

Abstract

Hydrogen sulfide (H2S) is a well-known toxic gas that has the smell of rotten eggs. This pungent gas was considered as a physiological mediator, after the identification of endogenous sulfides in the mammalian brain. H2S is produced from L-cysteine by enzymes such as cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT). We recently identified a fourth pathway, where H2S is produced from D-cysteine by the enzyme D-amino acid oxidase (DAO) along with 3MST. We demonstrated that H2S is a neuromodulator that facilitates hippocampal long-term potentiation (LTP) by enhancing the activity of N-methyl-D-aspartate (NMDA) receptors. It also induces Ca(2+) influx in the astrocytes by activating the transient receptor potential ankyrin-1 (TRPA1) channels. In addition to being a signaling molecule, it also functions as a neuroprotective agent by enhancing the production of glutathione, a major intracellular antioxidant that scavenges the reactive oxygen species (ROS) in the mitochondria. H2S regulates the activity of the enzymes by incorporating the bound sulfane sulfur to cysteine residues. This modification is known as sulfhydration or sulfuration. The neuroprotective ubiquitin E3 ligase, parkin, enhances its neuroprotective activity by this modification. This review is focused on the functional role of H2S as a signaling molecule and as a cytoprotectant in the nervous system. In addition, this review shows the recent findings that indicate that the H2S-derived polysulfides found in the brain activate TRPA1 channels more potently than parental H2S.

Authors+Show Affiliations

National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan. Electronic address: kimura@ncnp.go.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24036365

Citation

Kimura, Hideo. "Physiological Role of Hydrogen Sulfide and Polysulfide in the Central Nervous System." Neurochemistry International, vol. 63, no. 5, 2013, pp. 492-7.
Kimura H. Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int. 2013;63(5):492-7.
Kimura, H. (2013). Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochemistry International, 63(5), 492-7. https://doi.org/10.1016/j.neuint.2013.09.003
Kimura H. Physiological Role of Hydrogen Sulfide and Polysulfide in the Central Nervous System. Neurochem Int. 2013;63(5):492-7. PubMed PMID: 24036365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological role of hydrogen sulfide and polysulfide in the central nervous system. A1 - Kimura,Hideo, Y1 - 2013/09/11/ PY - 2013/08/02/received PY - 2013/08/27/revised PY - 2013/09/02/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/6/3/medline KW - Bound sulfane sulfur KW - Cytoprotection KW - H(2)S KW - Polysulfides KW - Signaling KW - Sulfhydration KW - Sulfuration KW - TRP channels SP - 492 EP - 7 JF - Neurochemistry international JO - Neurochem Int VL - 63 IS - 5 N2 - Hydrogen sulfide (H2S) is a well-known toxic gas that has the smell of rotten eggs. This pungent gas was considered as a physiological mediator, after the identification of endogenous sulfides in the mammalian brain. H2S is produced from L-cysteine by enzymes such as cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT). We recently identified a fourth pathway, where H2S is produced from D-cysteine by the enzyme D-amino acid oxidase (DAO) along with 3MST. We demonstrated that H2S is a neuromodulator that facilitates hippocampal long-term potentiation (LTP) by enhancing the activity of N-methyl-D-aspartate (NMDA) receptors. It also induces Ca(2+) influx in the astrocytes by activating the transient receptor potential ankyrin-1 (TRPA1) channels. In addition to being a signaling molecule, it also functions as a neuroprotective agent by enhancing the production of glutathione, a major intracellular antioxidant that scavenges the reactive oxygen species (ROS) in the mitochondria. H2S regulates the activity of the enzymes by incorporating the bound sulfane sulfur to cysteine residues. This modification is known as sulfhydration or sulfuration. The neuroprotective ubiquitin E3 ligase, parkin, enhances its neuroprotective activity by this modification. This review is focused on the functional role of H2S as a signaling molecule and as a cytoprotectant in the nervous system. In addition, this review shows the recent findings that indicate that the H2S-derived polysulfides found in the brain activate TRPA1 channels more potently than parental H2S. SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/24036365/Physiological_role_of_hydrogen_sulfide_and_polysulfide_in_the_central_nervous_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(13)00229-5 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.