Tags

Type your tag names separated by a space and hit enter

Use of complementary and alternative medicine (CAM) and changes in depressive symptoms from 3 to 15 months after surgery for primary breast cancer: results from a nationwide cohort study.
Breast Cancer Res Treat. 2013 Sep; 141(2):277-85.BC

Abstract

Background This large population-based prospective study explored the associations between use of complementary and alternative medicine (CAM) and prevalence and changes in depressive symptoms from 3 to 15 months after surgery for primary breast cancer. Methods In an ongoing nationwide cohort study, depressive symptoms and the use of ten different types of CAM since time of diagnosis were assessed by questionnaire at 3 (N = 3233) and 15 months post-surgery (N = 2833). Clinical and socio-demopraphic variables were obtained from the Danish Breast Cancer Cooperative Group (DBCG) and national longitudinal registries. Results At 3 months post-surgery, 40.2 % reported having used CAM since the diagnosis, and in the time from 3 to 15 months after surgery, 49.9 % had used CAM. Compared with non-users, CAM users experienced more depressive symptoms at both 3 and 15 months follow-up when adjusting for several possible confounders. In a fully adjusted model, including all CAM variables and adjusting for depressive symptoms at 3 months, use of dietary/vitamin supplements was the only independent, statistically significant risk factor for experiencing more depressive symptoms at 15 months (RM = 1.10; 95 % CI 1.02-1.19, P = 0.014). Conclusion Cross-sectionally, CAM use was associated with higher levels of depressive symptoms at both time-points. Prospectively, users of dietary or vitamin supplements at 3 months after surgery reported higher levels of depressive symptoms than non-users 1 year later. Possible explanations could be an increased vulnerability for depressive symptoms among women using CAM or adverse effects of dietary or vitamin supplements.

Authors+Show Affiliations

Unit for Psychooncology and Health Psychology, Aarhus University Hospital & Aarhus University, Bartholins Allé 9, 8000, Aarhus C, Denmark, christina@psy.au.dk.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24036661

Citation

Pedersen, Christina Gundgaard, et al. "Use of Complementary and Alternative Medicine (CAM) and Changes in Depressive Symptoms From 3 to 15 Months After Surgery for Primary Breast Cancer: Results From a Nationwide Cohort Study." Breast Cancer Research and Treatment, vol. 141, no. 2, 2013, pp. 277-85.
Pedersen CG, Christensen S, Jensen AB, et al. Use of complementary and alternative medicine (CAM) and changes in depressive symptoms from 3 to 15 months after surgery for primary breast cancer: results from a nationwide cohort study. Breast Cancer Res Treat. 2013;141(2):277-85.
Pedersen, C. G., Christensen, S., Jensen, A. B., & Zachariae, R. (2013). Use of complementary and alternative medicine (CAM) and changes in depressive symptoms from 3 to 15 months after surgery for primary breast cancer: results from a nationwide cohort study. Breast Cancer Research and Treatment, 141(2), 277-85. https://doi.org/10.1007/s10549-013-2680-1
Pedersen CG, et al. Use of Complementary and Alternative Medicine (CAM) and Changes in Depressive Symptoms From 3 to 15 Months After Surgery for Primary Breast Cancer: Results From a Nationwide Cohort Study. Breast Cancer Res Treat. 2013;141(2):277-85. PubMed PMID: 24036661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of complementary and alternative medicine (CAM) and changes in depressive symptoms from 3 to 15 months after surgery for primary breast cancer: results from a nationwide cohort study. AU - Pedersen,Christina Gundgaard, AU - Christensen,Søren, AU - Jensen,Anders Bonde, AU - Zachariae,Robert, Y1 - 2013/09/14/ PY - 2013/06/24/received PY - 2013/08/21/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/5/9/medline SP - 277 EP - 85 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 141 IS - 2 N2 - Background This large population-based prospective study explored the associations between use of complementary and alternative medicine (CAM) and prevalence and changes in depressive symptoms from 3 to 15 months after surgery for primary breast cancer. Methods In an ongoing nationwide cohort study, depressive symptoms and the use of ten different types of CAM since time of diagnosis were assessed by questionnaire at 3 (N = 3233) and 15 months post-surgery (N = 2833). Clinical and socio-demopraphic variables were obtained from the Danish Breast Cancer Cooperative Group (DBCG) and national longitudinal registries. Results At 3 months post-surgery, 40.2 % reported having used CAM since the diagnosis, and in the time from 3 to 15 months after surgery, 49.9 % had used CAM. Compared with non-users, CAM users experienced more depressive symptoms at both 3 and 15 months follow-up when adjusting for several possible confounders. In a fully adjusted model, including all CAM variables and adjusting for depressive symptoms at 3 months, use of dietary/vitamin supplements was the only independent, statistically significant risk factor for experiencing more depressive symptoms at 15 months (RM = 1.10; 95 % CI 1.02-1.19, P = 0.014). Conclusion Cross-sectionally, CAM use was associated with higher levels of depressive symptoms at both time-points. Prospectively, users of dietary or vitamin supplements at 3 months after surgery reported higher levels of depressive symptoms than non-users 1 year later. Possible explanations could be an increased vulnerability for depressive symptoms among women using CAM or adverse effects of dietary or vitamin supplements. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/24036661/Use_of_complementary_and_alternative_medicine__CAM__and_changes_in_depressive_symptoms_from_3_to_15_months_after_surgery_for_primary_breast_cancer:_results_from_a_nationwide_cohort_study_ L2 - https://doi.org/10.1007/s10549-013-2680-1 DB - PRIME DP - Unbound Medicine ER -