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Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort.
Int J Cancer 2014; 134(6):1436-44IJ

Abstract

The insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We conducted a cross-sectional study nested within the large Mexican ESMaestras cohort to investigate the relation between circulating levels of IGF-I, IGFBP-3, the IGF-I/IGFBP-3 ratio, five common SNPs in the IGF-1, IGFBP-3 and IGF-1R genes and mammographic density in 593 premenopausal Mexican women. Mean age at mammogram was 43.1 (standard deviation, SD = 3.7) years, and average body mass index (BMI) at recruitment was 28.5 kg/m(2). Mean percent mammographic density was 36.5% (SD: 17.1), with mean dense tissue area of 48.3 (SD: 33.3) cm(2) . Mean IGF-I and IGFBP-3 concentrations were 15.33 (SD: 5.52) nmol/l and 114.96 (SD: 21.34) nmol/l, respectively. No significant associations were seen between percent density and biomarker concentrations, but women with higher IGF-I and IGF-I/IGFBP-3 concentrations had lower absolute dense (p(trend) = 0.03 and 0.09, respectively) and nondense tissue areas (p(trend) < 0.001 for both parameters). However, these associations were null after adjustment by BMI. SNPs in specific genes were associated with circulating levels of growth factors, but not with mammographic density features. These results do not support the hypothesis of a strong association between circulating levels of growth hormones and mammographic density in Mexican premenopausal women.

Authors+Show Affiliations

International Agency for Research on Cancer (IARC), Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24037648

Citation

Rinaldi, S, et al. "Circulating Concentrations of Insulin-like Growth factor-I, Insulin-like Growth Factor-binding Protein-3, Genetic Polymorphisms and Mammographic Density in Premenopausal Mexican Women: Results From the ESMaestras Cohort." International Journal of Cancer, vol. 134, no. 6, 2014, pp. 1436-44.
Rinaldi S, Biessy C, Hernandez M, et al. Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort. Int J Cancer. 2014;134(6):1436-44.
Rinaldi, S., Biessy, C., Hernandez, M., Lesueur, F., dos-Santos-Silva, I., Rice, M. S., ... Romieu, I. (2014). Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort. International Journal of Cancer, 134(6), pp. 1436-44. doi:10.1002/ijc.28469.
Rinaldi S, et al. Circulating Concentrations of Insulin-like Growth factor-I, Insulin-like Growth Factor-binding Protein-3, Genetic Polymorphisms and Mammographic Density in Premenopausal Mexican Women: Results From the ESMaestras Cohort. Int J Cancer. 2014 Mar 15;134(6):1436-44. PubMed PMID: 24037648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort. AU - Rinaldi,S, AU - Biessy,C, AU - Hernandez,M, AU - Lesueur,F, AU - dos-Santos-Silva,I, AU - Rice,M S, AU - Lajous,M, AU - Lopez-Ridaura,R, AU - Torres-Mejía,G, AU - Romieu,I, Y1 - 2013/10/05/ PY - 2013/06/24/received PY - 2013/08/07/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/2/26/medline KW - IGF KW - Mexican premenopausal women KW - genetic polymorphisms KW - mammographic density SP - 1436 EP - 44 JF - International journal of cancer JO - Int. J. Cancer VL - 134 IS - 6 N2 - The insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We conducted a cross-sectional study nested within the large Mexican ESMaestras cohort to investigate the relation between circulating levels of IGF-I, IGFBP-3, the IGF-I/IGFBP-3 ratio, five common SNPs in the IGF-1, IGFBP-3 and IGF-1R genes and mammographic density in 593 premenopausal Mexican women. Mean age at mammogram was 43.1 (standard deviation, SD = 3.7) years, and average body mass index (BMI) at recruitment was 28.5 kg/m(2). Mean percent mammographic density was 36.5% (SD: 17.1), with mean dense tissue area of 48.3 (SD: 33.3) cm(2) . Mean IGF-I and IGFBP-3 concentrations were 15.33 (SD: 5.52) nmol/l and 114.96 (SD: 21.34) nmol/l, respectively. No significant associations were seen between percent density and biomarker concentrations, but women with higher IGF-I and IGF-I/IGFBP-3 concentrations had lower absolute dense (p(trend) = 0.03 and 0.09, respectively) and nondense tissue areas (p(trend) < 0.001 for both parameters). However, these associations were null after adjustment by BMI. SNPs in specific genes were associated with circulating levels of growth factors, but not with mammographic density features. These results do not support the hypothesis of a strong association between circulating levels of growth hormones and mammographic density in Mexican premenopausal women. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/24037648/Circulating_concentrations_of_insulin_like_growth_factor_I_insulin_like_growth_factor_binding_protein_3_genetic_polymorphisms_and_mammographic_density_in_premenopausal_Mexican_women:_results_from_the_ESMaestras_cohort_ L2 - https://doi.org/10.1002/ijc.28469 DB - PRIME DP - Unbound Medicine ER -