Tags

Type your tag names separated by a space and hit enter

Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: a prospective fMRI study.
Hum Brain Mapp. 2014 May; 35(5):2470-82.HB

Abstract

Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal of the current functional magnetic resonance imaging study was to assess the predictive power of working-memory network function for future cannabis use and cannabis-related problem severity in heavy cannabis users. Tensor independent component analysis was used to investigate differences in working-memory network function between 32 heavy cannabis users and 41 nonusing controls during an N-back working-memory task. In addition, associations were examined between working-memory network function and cannabis use and problem severity at baseline and at 6-month follow-up. Behavioral performance and working-memory network function did not significantly differ between heavy cannabis users and controls. However, among heavy cannabis users, individual differences in working-memory network response had an independent effect on change in weekly cannabis use 6 months later (ΔR(2) = 0.11, P = 0.006, f(2) = 0.37) beyond baseline cannabis use (ΔR(2) = 0.41) and a behavioral measure of approach bias (ΔR(2) = 0.18): a stronger network response during the N-back task was related to an increase in weekly cannabis use. These findings imply that heavy cannabis users requiring greater effort to accurately complete an N-back working-memory task have a higher probability of escalating cannabis use. Working-memory network function may be a biomarker for the prediction of course and treatment outcome in cannabis users.

Authors+Show Affiliations

ADAPT-lab, Department of Psychology, University of Amsterdam, The Netherlands; Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands; Department of Psychology, Leiden University, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24038570

Citation

Cousijn, Janna, et al. "Effect of Baseline Cannabis Use and Working-memory Network Function On Changes in Cannabis Use in Heavy Cannabis Users: a Prospective fMRI Study." Human Brain Mapping, vol. 35, no. 5, 2014, pp. 2470-82.
Cousijn J, Wiers RW, Ridderinkhof KR, et al. Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: a prospective fMRI study. Hum Brain Mapp. 2014;35(5):2470-82.
Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., & Goudriaan, A. E. (2014). Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: a prospective fMRI study. Human Brain Mapping, 35(5), 2470-82. https://doi.org/10.1002/hbm.22342
Cousijn J, et al. Effect of Baseline Cannabis Use and Working-memory Network Function On Changes in Cannabis Use in Heavy Cannabis Users: a Prospective fMRI Study. Hum Brain Mapp. 2014;35(5):2470-82. PubMed PMID: 24038570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: a prospective fMRI study. AU - Cousijn,Janna, AU - Wiers,Reinout W, AU - Ridderinkhof,K Richard, AU - van den Brink,Wim, AU - Veltman,Dick J, AU - Goudriaan,Anna E, Y1 - 2013/09/03/ PY - 2012/06/04/received PY - 2013/04/08/revised PY - 2013/05/19/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/12/15/medline KW - N-back KW - cannabis KW - cannabis use disorder KW - fMRI KW - working-memory SP - 2470 EP - 82 JF - Human brain mapping JO - Hum Brain Mapp VL - 35 IS - 5 N2 - Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal of the current functional magnetic resonance imaging study was to assess the predictive power of working-memory network function for future cannabis use and cannabis-related problem severity in heavy cannabis users. Tensor independent component analysis was used to investigate differences in working-memory network function between 32 heavy cannabis users and 41 nonusing controls during an N-back working-memory task. In addition, associations were examined between working-memory network function and cannabis use and problem severity at baseline and at 6-month follow-up. Behavioral performance and working-memory network function did not significantly differ between heavy cannabis users and controls. However, among heavy cannabis users, individual differences in working-memory network response had an independent effect on change in weekly cannabis use 6 months later (ΔR(2) = 0.11, P = 0.006, f(2) = 0.37) beyond baseline cannabis use (ΔR(2) = 0.41) and a behavioral measure of approach bias (ΔR(2) = 0.18): a stronger network response during the N-back task was related to an increase in weekly cannabis use. These findings imply that heavy cannabis users requiring greater effort to accurately complete an N-back working-memory task have a higher probability of escalating cannabis use. Working-memory network function may be a biomarker for the prediction of course and treatment outcome in cannabis users. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/24038570/Effect_of_baseline_cannabis_use_and_working_memory_network_function_on_changes_in_cannabis_use_in_heavy_cannabis_users:_a_prospective_fMRI_study_ L2 - https://doi.org/10.1002/hbm.22342 DB - PRIME DP - Unbound Medicine ER -