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Factors relating to pregnancy and birth and the risk of childhood brain tumors: results from an Australian case-control study.
Pediatr Blood Cancer. 2014 Mar; 61(3):493-8.PB

Abstract

BACKGROUND

Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their causes are largely known. This study investigated the association between maternal and birth characteristics and risk of CBT.

PROCEDURES

Cases families were recruited from all 10 Australian pediatric oncology centers between 2005 and 2010. Control families were recruited via random-digit dialing, frequency matched to cases on the basis of child's age, sex, and State of residence. Maternal and birth characteristics of children were ascertained by questionnaires. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusting for relevant confounders.

RESULTS

For this analysis, data on 319 case children and 1,079 control children were available. No association was found between risk of CBT and birth weight, fetal growth, birth order, gestational age, or maternal body mass index. The ORs for inadequate and excessive maternal gestational weight gain (GWG) (Institute of Medicine 2009 guidelines) were 1.8 (95% CI 1.2-2.6) and 1.4 (95% CI 1.0-2.1), respectively; similar findings for GWG were seen across categories of child's age, fetal growth, maternal body mass index and height, maternal smoking, and parental education. Risk of low grade glioma appeared increased with preterm birth (OR 1.6 (95% CI 0.8-3.1) and admission to neonatal intensive care (NICU) for >2 days (OR 1.7, 95% CI 0.9-3.6).

CONCLUSION

We found little evidence of associations between risk of CBT and most birth characteristics. The associations we observed with GWG, prematurity and NICU admission require corroboration in other studies.

Authors+Show Affiliations

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24039139

Citation

Greenop, Kathryn R., et al. "Factors Relating to Pregnancy and Birth and the Risk of Childhood Brain Tumors: Results From an Australian Case-control Study." Pediatric Blood & Cancer, vol. 61, no. 3, 2014, pp. 493-8.
Greenop KR, Blair EM, Bower C, et al. Factors relating to pregnancy and birth and the risk of childhood brain tumors: results from an Australian case-control study. Pediatr Blood Cancer. 2014;61(3):493-8.
Greenop, K. R., Blair, E. M., Bower, C., Armstrong, B. K., & Milne, E. (2014). Factors relating to pregnancy and birth and the risk of childhood brain tumors: results from an Australian case-control study. Pediatric Blood & Cancer, 61(3), 493-8. https://doi.org/10.1002/pbc.24751
Greenop KR, et al. Factors Relating to Pregnancy and Birth and the Risk of Childhood Brain Tumors: Results From an Australian Case-control Study. Pediatr Blood Cancer. 2014;61(3):493-8. PubMed PMID: 24039139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors relating to pregnancy and birth and the risk of childhood brain tumors: results from an Australian case-control study. AU - Greenop,Kathryn R, AU - Blair,Eve M, AU - Bower,Carol, AU - Armstrong,Bruce K, AU - Milne,Elizabeth, Y1 - 2013/08/26/ PY - 2013/07/25/received PY - 2013/08/02/accepted PY - 2013/9/17/entrez PY - 2013/9/17/pubmed PY - 2014/3/14/medline KW - birth weight KW - brain tumors KW - cancer KW - child KW - fetal growth KW - gestational weight gain KW - neonatal intensive care KW - pregnancy SP - 493 EP - 8 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 61 IS - 3 N2 - BACKGROUND: Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their causes are largely known. This study investigated the association between maternal and birth characteristics and risk of CBT. PROCEDURES: Cases families were recruited from all 10 Australian pediatric oncology centers between 2005 and 2010. Control families were recruited via random-digit dialing, frequency matched to cases on the basis of child's age, sex, and State of residence. Maternal and birth characteristics of children were ascertained by questionnaires. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusting for relevant confounders. RESULTS: For this analysis, data on 319 case children and 1,079 control children were available. No association was found between risk of CBT and birth weight, fetal growth, birth order, gestational age, or maternal body mass index. The ORs for inadequate and excessive maternal gestational weight gain (GWG) (Institute of Medicine 2009 guidelines) were 1.8 (95% CI 1.2-2.6) and 1.4 (95% CI 1.0-2.1), respectively; similar findings for GWG were seen across categories of child's age, fetal growth, maternal body mass index and height, maternal smoking, and parental education. Risk of low grade glioma appeared increased with preterm birth (OR 1.6 (95% CI 0.8-3.1) and admission to neonatal intensive care (NICU) for >2 days (OR 1.7, 95% CI 0.9-3.6). CONCLUSION: We found little evidence of associations between risk of CBT and most birth characteristics. The associations we observed with GWG, prematurity and NICU admission require corroboration in other studies. SN - 1545-5017 UR - https://www.unboundmedicine.com/medline/citation/24039139/Factors_relating_to_pregnancy_and_birth_and_the_risk_of_childhood_brain_tumors:_results_from_an_Australian_case_control_study_ L2 - https://doi.org/10.1002/pbc.24751 DB - PRIME DP - Unbound Medicine ER -