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Management of diabetic complications: a chemical constituents based approach.
J Ethnopharmacol 2013; 150(1):51-70JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Long term hyperglycemia leads to development of complications associated with diabetes. Diabetic complications are now a global health problem without effective therapeutic approach. Hyperglycemia and oxidative stress are important components for the development of diabetic complications. Over the past few decades, herbal medicines have attracted much attention as potential therapeutic agents in the prevention and treatment of diabetic complications due to their multiple targets and less toxic side effects. This review aims to assess the current available knowledge of medicinal herbs for attenuation and management of diabetic complications and their underlying mechanisms.

MATERIAL AND METHODS

Bibliographic investigation was carried out by scrutinizing classical text books and peer reviewed papers, consulting worldwide accepted scientific databases (SCOPUS, PUBMED, SCIELO, NISCAIR, Google Scholar) to retrieve available published literature. The inclusion criteria for the selection of plants were based upon all medicinal herbs and their active compounds with attributed potentials in relieving diabetic complications. Moreover, plants which have potential effect in ameliorating oxidative stress in diabetic animals have been included.

RESULTS

Overall, 238 articles were reviewed for plant literature and out of the reviewed literature, 127 articles were selected for the study. Various medicinal plants/plant extracts containing flavonoids, alkaloids, phenolic compounds, terpenoids, saponins and phytosterol type chemical constituents were found to be effective in the management of diabetic complications. This effect might be attributed to amelioration of persistent hyperglycemia, oxidative stress and modulation of various metabolic pathways involved in the pathogenesis of diabetic complications.

CONCLUSION

Screening chemical candidate from herbal medicine might be a promising approach for new drug discovery to treat the diabetic complications. There is still a dire need to explore the mechanism of action of various plant extracts and their toxicity profile and to determine their role in therapy of diabetic complications. Moreover, a perfect rodent model which completely mimics human diabetic complications should be developed.

Authors+Show Affiliations

Maharishi Markandeshwar College of Pharmacy, Maharishi Markandeshwar University, Mullana-Ambala, Haryana 133207, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24041460

Citation

Singh, Randhir, et al. "Management of Diabetic Complications: a Chemical Constituents Based Approach." Journal of Ethnopharmacology, vol. 150, no. 1, 2013, pp. 51-70.
Singh R, Kaur N, Kishore L, et al. Management of diabetic complications: a chemical constituents based approach. J Ethnopharmacol. 2013;150(1):51-70.
Singh, R., Kaur, N., Kishore, L., & Gupta, G. K. (2013). Management of diabetic complications: a chemical constituents based approach. Journal of Ethnopharmacology, 150(1), pp. 51-70. doi:10.1016/j.jep.2013.08.051.
Singh R, et al. Management of Diabetic Complications: a Chemical Constituents Based Approach. J Ethnopharmacol. 2013 Oct 28;150(1):51-70. PubMed PMID: 24041460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of diabetic complications: a chemical constituents based approach. AU - Singh,Randhir, AU - Kaur,Navpreet, AU - Kishore,Lalit, AU - Gupta,Girish Kumar, Y1 - 2013/09/13/ PY - 2013/03/12/received PY - 2013/08/27/revised PY - 2013/08/28/accepted PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2014/5/20/medline KW - AGE KW - BB rats KW - BB/Wor rats KW - BBZDR/Wor rats KW - BioBreeding Zucker Diabetic rats KW - BioBreeding rats KW - BioBreeding/Worcester rats KW - Body weight KW - DAG KW - DPN KW - DRG KW - Diabetic complications KW - FOS KW - G-6-P KW - GK rats KW - GLP-1 KW - GPx KW - GSH KW - Goto-Kakizaki rats KW - HDL KW - HbA1c KW - High-density lipoprotein KW - IGF KW - IU KW - LBP-4 KW - LDL KW - Lycium barbarum Polysaccharides-4 KW - MAPK KW - MNCV KW - Medicinal plants KW - NCV KW - NF-κB KW - NGF KW - NO KW - NOD KW - OLETF rats KW - Otsuka Long Evans Tokushima Fatty rats KW - Oxidative stress KW - PKC KW - PPAR α KW - PPAR γ KW - RNS KW - ROS KW - SNCV KW - STZ KW - Streptozotocin KW - TBARS KW - TGF-β KW - TNF-α KW - VEGF KW - WBN/Kob rats KW - Wistar Bonn/Kobori rats KW - ZDF rats KW - Zucker Diabetic Fatty rats KW - advanced glycation end products KW - b.d. KW - b.w. KW - diabetic peripheral neuropathy KW - diacyl glycerol KW - dorsal root ganglion KW - fructooligosaccharides KW - glucagon like peptide-1 KW - glucose-6-phosphate KW - glutathione KW - glutathione peroxidase KW - glycosylated hemoglobin A1c KW - i.g. KW - i.p. KW - insulin-like growth factor KW - international units KW - intragastric route KW - intraperitoneal injection KW - low-density lipoprotein KW - mitogen activated protein kinase KW - motor nerve conduction velocity KW - nerve conduction velocity KW - nerve growth factor KW - nitric oxide KW - non-obese diabetic mice KW - nuclear factor kappa B KW - o.d. KW - once daily dose KW - p.o. KW - per os (oral administration) KW - peroxisome proliferators-activated receptor α KW - peroxisome proliferators-activated receptor γ KW - protein kinase C KW - reactive nitrogen species KW - reactive oxygen species KW - sensory nerve conduction velocity KW - thiobarbituric acid reactive substances KW - transforming growth factor-β KW - tumor necrosis factor-α KW - twice daily dose KW - v/v KW - vascular endothelial growth factor KW - volume by volume KW - w/w KW - weight by weight SP - 51 EP - 70 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 150 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Long term hyperglycemia leads to development of complications associated with diabetes. Diabetic complications are now a global health problem without effective therapeutic approach. Hyperglycemia and oxidative stress are important components for the development of diabetic complications. Over the past few decades, herbal medicines have attracted much attention as potential therapeutic agents in the prevention and treatment of diabetic complications due to their multiple targets and less toxic side effects. This review aims to assess the current available knowledge of medicinal herbs for attenuation and management of diabetic complications and their underlying mechanisms. MATERIAL AND METHODS: Bibliographic investigation was carried out by scrutinizing classical text books and peer reviewed papers, consulting worldwide accepted scientific databases (SCOPUS, PUBMED, SCIELO, NISCAIR, Google Scholar) to retrieve available published literature. The inclusion criteria for the selection of plants were based upon all medicinal herbs and their active compounds with attributed potentials in relieving diabetic complications. Moreover, plants which have potential effect in ameliorating oxidative stress in diabetic animals have been included. RESULTS: Overall, 238 articles were reviewed for plant literature and out of the reviewed literature, 127 articles were selected for the study. Various medicinal plants/plant extracts containing flavonoids, alkaloids, phenolic compounds, terpenoids, saponins and phytosterol type chemical constituents were found to be effective in the management of diabetic complications. This effect might be attributed to amelioration of persistent hyperglycemia, oxidative stress and modulation of various metabolic pathways involved in the pathogenesis of diabetic complications. CONCLUSION: Screening chemical candidate from herbal medicine might be a promising approach for new drug discovery to treat the diabetic complications. There is still a dire need to explore the mechanism of action of various plant extracts and their toxicity profile and to determine their role in therapy of diabetic complications. Moreover, a perfect rodent model which completely mimics human diabetic complications should be developed. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24041460/Management_of_diabetic_complications:_a_chemical_constituents_based_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00605-3 DB - PRIME DP - Unbound Medicine ER -