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Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children.
Chemosphere. 2013 Nov; 93(10):2390-8.C

Abstract

Exposure to endocrine disrupting chemicals such as bisphenol A (BPA) and phthalates is prevalent among children and adolescents, but little is known regarding important sources of exposure at these sensitive life stages. In this study, we measured urinary concentrations of BPA and nine phthalate metabolites in 108 Mexican children aged 8-13 years. Associations of age, time of day, and questionnaire items on external environment, water use, and food container use with specific gravity-corrected urinary concentrations were assessed, as were questionnaire items concerning the use of 17 personal care products in the past 48-h. As a secondary aim, third trimester urinary concentrations were measured in 99 mothers of these children, and the relationship between specific gravity-corrected urinary concentrations at these two time points was explored. After adjusting for potential confounding by other personal care product use in the past 48-h, there were statistically significant (p<0.05) positive associations in boys for cologne/perfume use and monoethyl phthalate (MEP), mono(3-carboxypropyl) phthalate (MCPP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and in girls for colored cosmetics use and mono-n-butyl phthalate (MBP), mono(2-ethylhexyl) phthalate (MEHP), MEHHP, MEOHP, and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), conditioner use and MEP, deodorant use and MEP, and other hair products use and MBP. There was a statistically significant positive trend for the number of personal care products used in the past 48-h and log-MEP in girls. However, there were no statistically significant associations between the analytes and the other questionnaire items and there were no strong correlations between the analytes measured during the third trimester and at 8-13 years of age. We demonstrated that personal care product use is associated with exposure to multiple phthalates in children. Due to rapid development, children may be susceptible to impacts from exposure to endocrine disrupting chemicals; thus, reduced or delayed use of certain personal care products among children may be warranted.

Authors+Show Affiliations

University of Michigan, School of Public Health, Department of Environmental Health Sciences, Ann Arbor, MI, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24041567

Citation

Lewis, Ryan C., et al. "Predictors of Urinary Bisphenol a and Phthalate Metabolite Concentrations in Mexican Children." Chemosphere, vol. 93, no. 10, 2013, pp. 2390-8.
Lewis RC, Meeker JD, Peterson KE, et al. Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children. Chemosphere. 2013;93(10):2390-8.
Lewis, R. C., Meeker, J. D., Peterson, K. E., Lee, J. M., Pace, G. G., Cantoral, A., & Téllez-Rojo, M. M. (2013). Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children. Chemosphere, 93(10), 2390-8. https://doi.org/10.1016/j.chemosphere.2013.08.038
Lewis RC, et al. Predictors of Urinary Bisphenol a and Phthalate Metabolite Concentrations in Mexican Children. Chemosphere. 2013;93(10):2390-8. PubMed PMID: 24041567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children. AU - Lewis,Ryan C, AU - Meeker,John D, AU - Peterson,Karen E, AU - Lee,Joyce M, AU - Pace,Gerry G, AU - Cantoral,Alejandra, AU - Téllez-Rojo,Martha Maria, Y1 - 2013/09/14/ PY - 2013/04/30/received PY - 2013/07/05/revised PY - 2013/08/10/accepted PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2014/5/29/medline KW - BBZP KW - BPA KW - Biomarker KW - Bisphenol A KW - CDC KW - Centers for Disease Control and Prevention KW - Children KW - DBP KW - DEHP KW - DEP KW - DIBP KW - DOP KW - ELEMENT KW - Early Life Exposure in Mexico to ENvironmental Toxicants KW - FDA KW - FSRA KW - Food and Drug Administration KW - GM KW - ID–LC–MS/MS KW - LOQ KW - MBP KW - MBZP KW - MCPP KW - MECPP KW - MEHHP KW - MEHP KW - MEOHP KW - MEP KW - MIBP KW - NHANES KW - National Health and Nutrition Examination Survey KW - Personal care products KW - Phthalates KW - SG KW - Urine KW - bisphenol A KW - butylbenzyl phthalate KW - di(2-ethylhexyl) phthalate KW - di-isobutyl-phthalate KW - di-n-butyl phthalate KW - di-n-octyl phthalate KW - diethyl phthalate KW - forward stepwise regression analysis KW - geometric mean KW - isotope dilution–liquid chromatography–tandem mass spectrometry KW - limit of quantitation KW - mono(2-ethyl-5-carboxypentyl) phthalate KW - mono(2-ethyl-5-hydroxyhexyl) phthalate KW - mono(2-ethyl-5-oxohexyl) phthalate KW - mono(2-ethylhexyl) phthalate KW - mono(3-carboxypropyl) phthalate KW - mono-isobutyl phthalate KW - mono-n-butyl phthalate KW - monobenzyl phthalate KW - monoethyl phthalate KW - specific gravity SP - 2390 EP - 8 JF - Chemosphere JO - Chemosphere VL - 93 IS - 10 N2 - Exposure to endocrine disrupting chemicals such as bisphenol A (BPA) and phthalates is prevalent among children and adolescents, but little is known regarding important sources of exposure at these sensitive life stages. In this study, we measured urinary concentrations of BPA and nine phthalate metabolites in 108 Mexican children aged 8-13 years. Associations of age, time of day, and questionnaire items on external environment, water use, and food container use with specific gravity-corrected urinary concentrations were assessed, as were questionnaire items concerning the use of 17 personal care products in the past 48-h. As a secondary aim, third trimester urinary concentrations were measured in 99 mothers of these children, and the relationship between specific gravity-corrected urinary concentrations at these two time points was explored. After adjusting for potential confounding by other personal care product use in the past 48-h, there were statistically significant (p<0.05) positive associations in boys for cologne/perfume use and monoethyl phthalate (MEP), mono(3-carboxypropyl) phthalate (MCPP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and in girls for colored cosmetics use and mono-n-butyl phthalate (MBP), mono(2-ethylhexyl) phthalate (MEHP), MEHHP, MEOHP, and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), conditioner use and MEP, deodorant use and MEP, and other hair products use and MBP. There was a statistically significant positive trend for the number of personal care products used in the past 48-h and log-MEP in girls. However, there were no statistically significant associations between the analytes and the other questionnaire items and there were no strong correlations between the analytes measured during the third trimester and at 8-13 years of age. We demonstrated that personal care product use is associated with exposure to multiple phthalates in children. Due to rapid development, children may be susceptible to impacts from exposure to endocrine disrupting chemicals; thus, reduced or delayed use of certain personal care products among children may be warranted. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/24041567/Predictors_of_urinary_bisphenol_A_and_phthalate_metabolite_concentrations_in_Mexican_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(13)01154-5 DB - PRIME DP - Unbound Medicine ER -