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Association of lower urinary tract symptom/benign prostatic hyperplasia measures with international index of erectile function 5 in middle-aged policemen of Korea and the role of metabolic syndrome and testosterone in their relationship.

Abstract

OBJECTIVE

To evaluate which among the lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH) measures is the most relevant to erectile dysfunction (ED) and elucidate the role of metabolic syndrome (MetS) and testosterone in their relationship.

METHODS

A total of 2564 policemen aged 40-59 years who had participated in a health examination were included. LUTS/BPH and ED were evaluated by the international prostate symptoms score (IPSS), transrectal ultrasonography, uroflowmetry, postvoid residual urine volume (PVR), and international index of erectile function questionnaire 5 (IIEF-5). Spearman correlation tests, multiple linear regression tests, and logistic regression analyses were used.

RESULTS

The median age was 49.0 years; the median total IPSS and IIEF scores were 9 and 19, respectively. Among the LUTS/BPH measures, IPSS (r = -0.311, P <.001) showed the highest correlation coefficient with IIEF, followed by total prostate volume (r = -0.082, P <.001), PVR (r = -0.080, P <.001), and maximal flow rate (r = 0.049, P = .014). In addition, only IPSS was significantly correlated with the IIEF score after adjusting for age, testosterone, and MetS. The severity of LUTS, as assessed by IPSS, was also significantly correlated with moderate to severe ED (IIEF ≤ 11), after adjusting for age, testosterone, MetS, and other LUTS/BPH measures. On multiple linear regression test, adjustment of Mets changed the P value and beta value of LUTS/BPH measures. However, there were no changes after adjusting testosterone.

CONCLUSION

IPSS is the most powerful predictor of ED among the LUTS/BPH measures in middle-aged policemen. In addition, MetS might be a plausible explanation for the relationship between LUTS/BPH and ED.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Urology, National Police Hospital, Seoul, Republic of Korea. Electronic address: sinbanpolee@gmail.com.

    ,

    Source

    Urology 82:5 2013 Nov pg 1008-12

    MeSH

    Adult
    Blood Glucose
    Erectile Dysfunction
    Humans
    Male
    Metabolic Syndrome
    Middle Aged
    Occupations
    Police
    Prostatic Hyperplasia
    Regression Analysis
    Republic of Korea
    Risk Factors
    Severity of Illness Index
    Surveys and Questionnaires
    Testosterone
    Ultrasonography
    Urinary Tract

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24041675

    Citation

    Lee, Jun Ho, et al. "Association of Lower Urinary Tract Symptom/benign Prostatic Hyperplasia Measures With International Index of Erectile Function 5 in Middle-aged Policemen of Korea and the Role of Metabolic Syndrome and Testosterone in Their Relationship." Urology, vol. 82, no. 5, 2013, pp. 1008-12.
    Lee JH, Kwon H, Park YW. Association of lower urinary tract symptom/benign prostatic hyperplasia measures with international index of erectile function 5 in middle-aged policemen of Korea and the role of metabolic syndrome and testosterone in their relationship. Urology. 2013;82(5):1008-12.
    Lee, J. H., Kwon, H., & Park, Y. W. (2013). Association of lower urinary tract symptom/benign prostatic hyperplasia measures with international index of erectile function 5 in middle-aged policemen of Korea and the role of metabolic syndrome and testosterone in their relationship. Urology, 82(5), pp. 1008-12. doi:10.1016/j.urology.2013.07.003.
    Lee JH, Kwon H, Park YW. Association of Lower Urinary Tract Symptom/benign Prostatic Hyperplasia Measures With International Index of Erectile Function 5 in Middle-aged Policemen of Korea and the Role of Metabolic Syndrome and Testosterone in Their Relationship. Urology. 2013;82(5):1008-12. PubMed PMID: 24041675.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of lower urinary tract symptom/benign prostatic hyperplasia measures with international index of erectile function 5 in middle-aged policemen of Korea and the role of metabolic syndrome and testosterone in their relationship. AU - Lee,Jun Ho, AU - Kwon,Hanna, AU - Park,Yeon Won, Y1 - 2013/09/13/ PY - 2013/06/10/received PY - 2013/06/28/revised PY - 2013/07/01/accepted PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2014/10/14/medline SP - 1008 EP - 12 JF - Urology JO - Urology VL - 82 IS - 5 N2 - OBJECTIVE: To evaluate which among the lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH) measures is the most relevant to erectile dysfunction (ED) and elucidate the role of metabolic syndrome (MetS) and testosterone in their relationship. METHODS: A total of 2564 policemen aged 40-59 years who had participated in a health examination were included. LUTS/BPH and ED were evaluated by the international prostate symptoms score (IPSS), transrectal ultrasonography, uroflowmetry, postvoid residual urine volume (PVR), and international index of erectile function questionnaire 5 (IIEF-5). Spearman correlation tests, multiple linear regression tests, and logistic regression analyses were used. RESULTS: The median age was 49.0 years; the median total IPSS and IIEF scores were 9 and 19, respectively. Among the LUTS/BPH measures, IPSS (r = -0.311, P <.001) showed the highest correlation coefficient with IIEF, followed by total prostate volume (r = -0.082, P <.001), PVR (r = -0.080, P <.001), and maximal flow rate (r = 0.049, P = .014). In addition, only IPSS was significantly correlated with the IIEF score after adjusting for age, testosterone, and MetS. The severity of LUTS, as assessed by IPSS, was also significantly correlated with moderate to severe ED (IIEF ≤ 11), after adjusting for age, testosterone, MetS, and other LUTS/BPH measures. On multiple linear regression test, adjustment of Mets changed the P value and beta value of LUTS/BPH measures. However, there were no changes after adjusting testosterone. CONCLUSION: IPSS is the most powerful predictor of ED among the LUTS/BPH measures in middle-aged policemen. In addition, MetS might be a plausible explanation for the relationship between LUTS/BPH and ED. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/24041675/Association_of_lower_urinary_tract_symptom/benign_prostatic_hyperplasia_measures_with_international_index_of_erectile_function_5_in_middle_aged_policemen_of_Korea_and_the_role_of_metabolic_syndrome_and_testosterone_in_their_relationship_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(13)00834-0 DB - PRIME DP - Unbound Medicine ER -