Tags

Type your tag names separated by a space and hit enter

Lactococcus lactis BFE920 activates the innate immune system of olive flounder (Paralichthys olivaceus), resulting in protection against Streptococcus iniae infection and enhancing feed efficiency and weight gain in large-scale field studies.
Fish Shellfish Immunol. 2013 Nov; 35(5):1585-90.FS

Abstract

The protective effect of a food-grade lactic acid bacterium Lactococcus lactis BFE920 against disease of olive flounder (Paralichthys olivaceus) cultivated on a large scale was studied. Initially, antimicrobial activity of L. lactis against several fish pathogens was evaluated in vitro; the probiotic showed strong antibacterial activity against Streptococcus iniae, Streptococcus parauberis and Enterococcus viikkiensis, and moderate activity against Lactococcus garviae. When olive flounders were fed for two weeks with experimental diets containing varying concentrations of L. lactis (1 × 10(6), 5 × 10(6), 2.5 × 10(7) and 1.25 × 10(8) CFU/g feed), all the experimental feed groups showed 68-77% survival upon challenge with S. iniae. A field-scale feeding trial with L. lactis dietary supplement was conducted in a local fish farm (n = 12,000) for three months, and disease resistance, innate immune parameters and growth performance were evaluated. The average weight gain and feed efficiency were increased up to 6.8% and 8.5%, respectively. At the end of the feeding trial, the olive flounders were challenged with S. iniae. The L. lactis-fed group was protected from S. iniae challenge with a 66% survival rate. This disease protection is due to the flounder's innate immunity activated by the L. lactis administration: increased lysosomal activities and production of IL-12 and IFN-γ. These data clearly indicated that L. lactis BFE920 may be developed as a functional feed additive for protection against diseases, and for enhancement of feed efficiency and weight gain in olive flounder farming.

Authors+Show Affiliations

School of Life Science, Handong University, Pohang 791-708, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24041843

Citation

Kim, Daniel, et al. "Lactococcus Lactis BFE920 Activates the Innate Immune System of Olive Flounder (Paralichthys Olivaceus), Resulting in Protection Against Streptococcus Iniae Infection and Enhancing Feed Efficiency and Weight Gain in Large-scale Field Studies." Fish & Shellfish Immunology, vol. 35, no. 5, 2013, pp. 1585-90.
Kim D, Beck BR, Heo SB, et al. Lactococcus lactis BFE920 activates the innate immune system of olive flounder (Paralichthys olivaceus), resulting in protection against Streptococcus iniae infection and enhancing feed efficiency and weight gain in large-scale field studies. Fish Shellfish Immunol. 2013;35(5):1585-90.
Kim, D., Beck, B. R., Heo, S. B., Kim, J., Kim, H. D., Lee, S. M., Kim, Y., Oh, S. Y., Lee, K., Do, H., Lee, K., Holzapfel, W. H., & Song, S. K. (2013). Lactococcus lactis BFE920 activates the innate immune system of olive flounder (Paralichthys olivaceus), resulting in protection against Streptococcus iniae infection and enhancing feed efficiency and weight gain in large-scale field studies. Fish & Shellfish Immunology, 35(5), 1585-90. https://doi.org/10.1016/j.fsi.2013.09.008
Kim D, et al. Lactococcus Lactis BFE920 Activates the Innate Immune System of Olive Flounder (Paralichthys Olivaceus), Resulting in Protection Against Streptococcus Iniae Infection and Enhancing Feed Efficiency and Weight Gain in Large-scale Field Studies. Fish Shellfish Immunol. 2013;35(5):1585-90. PubMed PMID: 24041843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lactococcus lactis BFE920 activates the innate immune system of olive flounder (Paralichthys olivaceus), resulting in protection against Streptococcus iniae infection and enhancing feed efficiency and weight gain in large-scale field studies. AU - Kim,Daniel, AU - Beck,Bo Ram, AU - Heo,Saet-Byeol, AU - Kim,Jungjoon, AU - Kim,Hyun Duk, AU - Lee,Sun-Min, AU - Kim,Youngchan, AU - Oh,So Young, AU - Lee,Kyungro, AU - Do,HyungKi, AU - Lee,KwanHee, AU - Holzapfel,Wilhelm H, AU - Song,Seong Kyu, Y1 - 2013/09/13/ PY - 2013/07/22/received PY - 2013/08/30/revised PY - 2013/09/02/accepted PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2014/5/10/medline KW - IFN-γ KW - IL-12 KW - Lactococcus lactis BFE920 KW - Olive flounder KW - Probiotics SP - 1585 EP - 90 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 35 IS - 5 N2 - The protective effect of a food-grade lactic acid bacterium Lactococcus lactis BFE920 against disease of olive flounder (Paralichthys olivaceus) cultivated on a large scale was studied. Initially, antimicrobial activity of L. lactis against several fish pathogens was evaluated in vitro; the probiotic showed strong antibacterial activity against Streptococcus iniae, Streptococcus parauberis and Enterococcus viikkiensis, and moderate activity against Lactococcus garviae. When olive flounders were fed for two weeks with experimental diets containing varying concentrations of L. lactis (1 × 10(6), 5 × 10(6), 2.5 × 10(7) and 1.25 × 10(8) CFU/g feed), all the experimental feed groups showed 68-77% survival upon challenge with S. iniae. A field-scale feeding trial with L. lactis dietary supplement was conducted in a local fish farm (n = 12,000) for three months, and disease resistance, innate immune parameters and growth performance were evaluated. The average weight gain and feed efficiency were increased up to 6.8% and 8.5%, respectively. At the end of the feeding trial, the olive flounders were challenged with S. iniae. The L. lactis-fed group was protected from S. iniae challenge with a 66% survival rate. This disease protection is due to the flounder's innate immunity activated by the L. lactis administration: increased lysosomal activities and production of IL-12 and IFN-γ. These data clearly indicated that L. lactis BFE920 may be developed as a functional feed additive for protection against diseases, and for enhancement of feed efficiency and weight gain in olive flounder farming. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/24041843/Lactococcus_lactis_BFE920_activates_the_innate_immune_system_of_olive_flounder__Paralichthys_olivaceus__resulting_in_protection_against_Streptococcus_iniae_infection_and_enhancing_feed_efficiency_and_weight_gain_in_large_scale_field_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(13)00753-5 DB - PRIME DP - Unbound Medicine ER -