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Segmental progression of cardinal motor symptoms in Parkinson's disease: a pilot study suggesting a practical approach to rate disease course in the early stages.
Parkinsonism Relat Disord. 2013 Dec; 19(12):1143-8.PR

Abstract

Little is known about the anatomical progression over the body segments of extrapyramidal signs in Parkinson's disease (PD); furthermore a great unmet need is the availability of instruments able to detect disease progression, even in the early phase. The purpose of this study is to demonstrate that assessing topographical distribution of the cardinal motor features of PD may significantly improve the evaluation of disease progression in the early stages. Forty-four drug-naïve PD patients were included in the study. Presence or absence of bradykinesia, rest tremor and rigidity was derived from Unified Parkinson's disease rating scale part III (UPDRS-III) in five different anatomical segments: axial, right and left upper- and lower-limbs. Based on this approach, four new scores were computed evaluating the anatomical spread of the cardinal motor symptoms of PD on the five body segments over a 18-month follow-up period. The four new scores included: the Bradykinesia Segmental Score, the Tremor Segmental Score, the Rigidity Segmental Score, measuring the occurrence of each motor symptom in different segments and the Combined Segmental Score evaluating the occurrence of any motor symptom in different anatomical regions. Data were analyzed using a repeated measures analysis of variance. The Combined Segmental Score showed a significant progression over time whereas the Hoehn and Yahr and the UPDRS-III scores did not. We suggest that a simple approach evaluating the anatomical distribution of motor symptoms and their progression over the body segments may be a useful complement to the classical rating tools to assess progression in early PD.

Authors+Show Affiliations

Department of Neurological Sciences, University Federico II, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24041938

Citation

Picillo, Marina, et al. "Segmental Progression of Cardinal Motor Symptoms in Parkinson's Disease: a Pilot Study Suggesting a Practical Approach to Rate Disease Course in the Early Stages." Parkinsonism & Related Disorders, vol. 19, no. 12, 2013, pp. 1143-8.
Picillo M, Amboni M, Erro R, et al. Segmental progression of cardinal motor symptoms in Parkinson's disease: a pilot study suggesting a practical approach to rate disease course in the early stages. Parkinsonism Relat Disord. 2013;19(12):1143-8.
Picillo, M., Amboni, M., Erro, R., Vitale, C., Longo, K., Pellecchia, M. T., Cozzolino, A., Moccia, M., Allocca, R., & Barone, P. (2013). Segmental progression of cardinal motor symptoms in Parkinson's disease: a pilot study suggesting a practical approach to rate disease course in the early stages. Parkinsonism & Related Disorders, 19(12), 1143-8. https://doi.org/10.1016/j.parkreldis.2013.08.015
Picillo M, et al. Segmental Progression of Cardinal Motor Symptoms in Parkinson's Disease: a Pilot Study Suggesting a Practical Approach to Rate Disease Course in the Early Stages. Parkinsonism Relat Disord. 2013;19(12):1143-8. PubMed PMID: 24041938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Segmental progression of cardinal motor symptoms in Parkinson's disease: a pilot study suggesting a practical approach to rate disease course in the early stages. AU - Picillo,Marina, AU - Amboni,Marianna, AU - Erro,Roberto, AU - Vitale,Carmine, AU - Longo,Katia, AU - Pellecchia,Maria Teresa, AU - Cozzolino,Autilia, AU - Moccia,Marcello, AU - Allocca,Roberto, AU - Barone,Paolo, Y1 - 2013/09/02/ PY - 2013/03/19/received PY - 2013/07/10/revised PY - 2013/08/22/accepted PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2014/8/15/medline KW - Motor symptoms KW - Parkinson's disease KW - Progression SP - 1143 EP - 8 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 19 IS - 12 N2 - Little is known about the anatomical progression over the body segments of extrapyramidal signs in Parkinson's disease (PD); furthermore a great unmet need is the availability of instruments able to detect disease progression, even in the early phase. The purpose of this study is to demonstrate that assessing topographical distribution of the cardinal motor features of PD may significantly improve the evaluation of disease progression in the early stages. Forty-four drug-naïve PD patients were included in the study. Presence or absence of bradykinesia, rest tremor and rigidity was derived from Unified Parkinson's disease rating scale part III (UPDRS-III) in five different anatomical segments: axial, right and left upper- and lower-limbs. Based on this approach, four new scores were computed evaluating the anatomical spread of the cardinal motor symptoms of PD on the five body segments over a 18-month follow-up period. The four new scores included: the Bradykinesia Segmental Score, the Tremor Segmental Score, the Rigidity Segmental Score, measuring the occurrence of each motor symptom in different segments and the Combined Segmental Score evaluating the occurrence of any motor symptom in different anatomical regions. Data were analyzed using a repeated measures analysis of variance. The Combined Segmental Score showed a significant progression over time whereas the Hoehn and Yahr and the UPDRS-III scores did not. We suggest that a simple approach evaluating the anatomical distribution of motor symptoms and their progression over the body segments may be a useful complement to the classical rating tools to assess progression in early PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/24041938/Segmental_progression_of_cardinal_motor_symptoms_in_Parkinson's_disease:_a_pilot_study_suggesting_a_practical_approach_to_rate_disease_course_in_the_early_stages_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(13)00309-X DB - PRIME DP - Unbound Medicine ER -