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Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control.
Neurobiol Aging. 2014 Feb; 35(2):418-20.NA

Abstract

Recently, α-synuclein (α-syn) and DJ-1, 2 proteins critically involved in Parkinson's disease (PD), have been shown to be present in saliva, suggesting their potential utility as biomarkers of PD. However, the origin and influence of demographic characteristics (e.g., age or sex) on these proteins are unknown. We identified cheek epithelium, which forms the majority of the cellular component of saliva and is readily accessible clinically, as 1 of several potential sources of salivary α-syn and DJ-1. However, no PD-related trend in the cellular component was present. In the supernatant collected from 198 healthy subjects, no correlation was seen between salivary DJ-1 or α-syn with age. When male and female subjects were analyzed separately, a weak age-dependent increase in DJ-1 level was present in male subjects, along with slightly increased α-syn in female subjects. These results, albeit largely negative, provide critical information for understanding the salivary gland pathology and saliva as a PD biomarker source, and must be considered in future investigations of salivary changes in PD.

Authors+Show Affiliations

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24041968

Citation

Stewart, Tessandra, et al. "Cheek Cell-derived Α-synuclein and DJ-1 Do Not Differentiate Parkinson's Disease From Control." Neurobiology of Aging, vol. 35, no. 2, 2014, pp. 418-20.
Stewart T, Sui YT, Gonzalez-Cuyar LF, et al. Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control. Neurobiol Aging. 2014;35(2):418-20.
Stewart, T., Sui, Y. T., Gonzalez-Cuyar, L. F., Wong, D. T., Akin, D. M., Tumas, V., Aasly, J., Ashmore, E., Aro, P., Ginghina, C., Korff, A., Zabetian, C. P., Leverenz, J. B., Shi, M., & Zhang, J. (2014). Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control. Neurobiology of Aging, 35(2), 418-20. https://doi.org/10.1016/j.neurobiolaging.2013.08.008
Stewart T, et al. Cheek Cell-derived Α-synuclein and DJ-1 Do Not Differentiate Parkinson's Disease From Control. Neurobiol Aging. 2014;35(2):418-20. PubMed PMID: 24041968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control. AU - Stewart,Tessandra, AU - Sui,Yu-Ting, AU - Gonzalez-Cuyar,Luis F, AU - Wong,David T W, AU - Akin,David M, AU - Tumas,Vitor, AU - Aasly,Jan, AU - Ashmore,Emily, AU - Aro,Patrick, AU - Ginghina,Carmen, AU - Korff,Ane, AU - Zabetian,Cyrus P, AU - Leverenz,James B, AU - Shi,Min, AU - Zhang,Jing, Y1 - 2013/09/13/ PY - 2013/05/01/received PY - 2013/08/06/revised PY - 2013/08/10/accepted PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2014/8/26/medline KW - Biomarker KW - DJ-1 KW - Movement disorder KW - Neurodegeneration KW - Parkinson's disease KW - Saliva KW - α-Synuclein SP - 418 EP - 20 JF - Neurobiology of aging JO - Neurobiol Aging VL - 35 IS - 2 N2 - Recently, α-synuclein (α-syn) and DJ-1, 2 proteins critically involved in Parkinson's disease (PD), have been shown to be present in saliva, suggesting their potential utility as biomarkers of PD. However, the origin and influence of demographic characteristics (e.g., age or sex) on these proteins are unknown. We identified cheek epithelium, which forms the majority of the cellular component of saliva and is readily accessible clinically, as 1 of several potential sources of salivary α-syn and DJ-1. However, no PD-related trend in the cellular component was present. In the supernatant collected from 198 healthy subjects, no correlation was seen between salivary DJ-1 or α-syn with age. When male and female subjects were analyzed separately, a weak age-dependent increase in DJ-1 level was present in male subjects, along with slightly increased α-syn in female subjects. These results, albeit largely negative, provide critical information for understanding the salivary gland pathology and saliva as a PD biomarker source, and must be considered in future investigations of salivary changes in PD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/24041968/Cheek_cell_derived_α_synuclein_and_DJ_1_do_not_differentiate_Parkinson's_disease_from_control_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(13)00342-4 DB - PRIME DP - Unbound Medicine ER -