Tags

Type your tag names separated by a space and hit enter

Plague gives surprises in the first decade of the 21st century in the United States and worldwide.
Am J Trop Med Hyg. 2013 Oct; 89(4):788-93.AJ

Abstract

Plague is an ancient disease caused by the bacterium Yersinia pestis and transmitted by rodent flea bites that continues to surprise us with first-ever events. This review documents plague in human cases in the 1st decade of the 21st century and updates our knowledge of clinical manifestations, transmission during outbreaks, diagnostic testing, antimicrobial treatment, and vaccine development. In the United States, 57 persons were reported to have the disease, of which seven died. Worldwide, 21,725 persons were affected with 1,612 deaths, for a case-fatality rate of 7.4%. The Congo reported more cases than any other country, including two large outbreaks of pneumonic plague, surpassing Madagascar, which had the most cases in the previous decade. Two United States scientists suffered fatal accidental exposures: a wildlife biologist, who carried out an autopsy on a mountain lion in Arizona in 2007, and a geneticist with subclinical hemochromatosis in Chicago, who was handling an avirulent strain of Y. pestis in 2009. Antimicrobial drugs given early after the onset of symptoms prevented many deaths; those recommended for treatment and prophylaxis included gentamicin, doxycycline, and fluoroquinolones, although fluoroquinolones have not been adequately tested in humans. Fleas that do not have their guts blocked by clotted blood meals were shown to be better transmitters of plague than blocked fleas. Under development for protection against bioterrorist use, a subunit vaccine containing F1 and V antigens of Y. pestis was administered to human volunteers eliciting antibodies without any serious side effects. These events, although showing progress, suggest that plague will persist in rodent reservoirs mostly in African countries burdened by poverty and civil unrest, causing death when patients fail to receive prompt antimicrobial treatment.

Authors+Show Affiliations

Ross University School of Medicine, Portsmouth, Dominica, West Indies.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24043686

Citation

Butler, Thomas. "Plague Gives Surprises in the First Decade of the 21st Century in the United States and Worldwide." The American Journal of Tropical Medicine and Hygiene, vol. 89, no. 4, 2013, pp. 788-93.
Butler T. Plague gives surprises in the first decade of the 21st century in the United States and worldwide. Am J Trop Med Hyg. 2013;89(4):788-93.
Butler, T. (2013). Plague gives surprises in the first decade of the 21st century in the United States and worldwide. The American Journal of Tropical Medicine and Hygiene, 89(4), 788-93. https://doi.org/10.4269/ajtmh.13-0191
Butler T. Plague Gives Surprises in the First Decade of the 21st Century in the United States and Worldwide. Am J Trop Med Hyg. 2013;89(4):788-93. PubMed PMID: 24043686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plague gives surprises in the first decade of the 21st century in the United States and worldwide. A1 - Butler,Thomas, Y1 - 2013/09/16/ PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2013/12/16/medline SP - 788 EP - 93 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 89 IS - 4 N2 - Plague is an ancient disease caused by the bacterium Yersinia pestis and transmitted by rodent flea bites that continues to surprise us with first-ever events. This review documents plague in human cases in the 1st decade of the 21st century and updates our knowledge of clinical manifestations, transmission during outbreaks, diagnostic testing, antimicrobial treatment, and vaccine development. In the United States, 57 persons were reported to have the disease, of which seven died. Worldwide, 21,725 persons were affected with 1,612 deaths, for a case-fatality rate of 7.4%. The Congo reported more cases than any other country, including two large outbreaks of pneumonic plague, surpassing Madagascar, which had the most cases in the previous decade. Two United States scientists suffered fatal accidental exposures: a wildlife biologist, who carried out an autopsy on a mountain lion in Arizona in 2007, and a geneticist with subclinical hemochromatosis in Chicago, who was handling an avirulent strain of Y. pestis in 2009. Antimicrobial drugs given early after the onset of symptoms prevented many deaths; those recommended for treatment and prophylaxis included gentamicin, doxycycline, and fluoroquinolones, although fluoroquinolones have not been adequately tested in humans. Fleas that do not have their guts blocked by clotted blood meals were shown to be better transmitters of plague than blocked fleas. Under development for protection against bioterrorist use, a subunit vaccine containing F1 and V antigens of Y. pestis was administered to human volunteers eliciting antibodies without any serious side effects. These events, although showing progress, suggest that plague will persist in rodent reservoirs mostly in African countries burdened by poverty and civil unrest, causing death when patients fail to receive prompt antimicrobial treatment. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/24043686/full_citation L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.13-0191?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.