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The diagnostic sensitivity of dynamic contrast-enhanced magnetic resonance imaging and breast-specific gamma imaging in women with calcified and non-calcified DCIS.
Acta Radiol. 2014 Jul; 55(6):668-75.AR

Abstract

BACKGROUND

Early detection of breast cancer reduces mortality. Therefore, diagnosis of ductal carcinoma in situ (DCIS) is important.

PURPOSE

To compare the sensitivities of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and breast-specific gamma imaging (BSGI) in pathologically proven calcified and non-calcified DCIS.

MATERIAL AND METHODS

Thirty-five patients with pathologically diagnosed DCIS from 1 June 2009 through 31 December 2011, underwent a protocol involving both breast MRI and BSGI. Each image was assessed by a separate dedicated breast radiologist. All lesions were divided into two groups; with or without microcalcifications on mammograms. In cases without microcalcifications, we recorded the mass, asymmetry, or negative findings on mammography. On MRI, the enhancement pattern was categorized as mass or non-mass-like enhancement. On BSGI, the uptake pattern was analyzed. The histopathological features of the lesions were obtained. Statistical analysis of the sensitivity of each modality was performed using McNemar's test.

RESULTS

Thirty-five women with a mean age of 48 years (range, 26-69 years) were enrolled in the study. The total sensitivities of MRI and BSGI in the 35 cases were 91.4% (32 of 35 DCIS) and 68.6% (24 of 35 DCIS), respectively. Eighteen cases with DCIS displayed microcalcifications on mammography, while 17 cases did not. Of these 17 cases without microcalcifications on mammography, 88.2% (15 of 17 DCIS) were detected by MRI and 52.9% (9 of 17 DCIS) by BSGI. Of 18 cases with microcalcifications on mammography, 94.4% (17 of 18 DCIS) were detected by MRI and 83.3% (15 of 19 DCIS) by BSGI.

CONCLUSION

MRI showed a higher sensitivity for the detection of calcified and non-calcified DCIS and is more helpful than BSGI in cases without microcalcifications on mammography.

Authors+Show Affiliations

Department of Radiology, Mokdong Hospital, Ewha Womans University, School of Medicine, Seoul, Republic of Korea.Department of Radiology, Chuncheongnam-do Seosan Medical Center, Chuncheongnam-do, Republic of Korea.Department of Radiology, Mokdong Hospital, Ewha Womans University, School of Medicine, Seoul, Republic of Korea escha@ewha.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24043881

Citation

Kim, Jin Sil, et al. "The Diagnostic Sensitivity of Dynamic Contrast-enhanced Magnetic Resonance Imaging and Breast-specific Gamma Imaging in Women With Calcified and Non-calcified DCIS." Acta Radiologica (Stockholm, Sweden : 1987), vol. 55, no. 6, 2014, pp. 668-75.
Kim JS, Lee SM, Cha ES. The diagnostic sensitivity of dynamic contrast-enhanced magnetic resonance imaging and breast-specific gamma imaging in women with calcified and non-calcified DCIS. Acta Radiol. 2014;55(6):668-75.
Kim, J. S., Lee, S. M., & Cha, E. S. (2014). The diagnostic sensitivity of dynamic contrast-enhanced magnetic resonance imaging and breast-specific gamma imaging in women with calcified and non-calcified DCIS. Acta Radiologica (Stockholm, Sweden : 1987), 55(6), 668-75. https://doi.org/10.1177/0284185113505086
Kim JS, Lee SM, Cha ES. The Diagnostic Sensitivity of Dynamic Contrast-enhanced Magnetic Resonance Imaging and Breast-specific Gamma Imaging in Women With Calcified and Non-calcified DCIS. Acta Radiol. 2014;55(6):668-75. PubMed PMID: 24043881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnostic sensitivity of dynamic contrast-enhanced magnetic resonance imaging and breast-specific gamma imaging in women with calcified and non-calcified DCIS. AU - Kim,Jin Sil, AU - Lee,Sang Min, AU - Cha,Eun Suk, Y1 - 2013/09/16/ PY - 2013/9/18/entrez PY - 2013/9/18/pubmed PY - 2015/4/11/medline KW - Ductal carcinoma in situ KW - breast specific gamma imaging KW - magnetic resonance imaging KW - mammography KW - microcalcification KW - sensitivity SP - 668 EP - 75 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 55 IS - 6 N2 - BACKGROUND: Early detection of breast cancer reduces mortality. Therefore, diagnosis of ductal carcinoma in situ (DCIS) is important. PURPOSE: To compare the sensitivities of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and breast-specific gamma imaging (BSGI) in pathologically proven calcified and non-calcified DCIS. MATERIAL AND METHODS: Thirty-five patients with pathologically diagnosed DCIS from 1 June 2009 through 31 December 2011, underwent a protocol involving both breast MRI and BSGI. Each image was assessed by a separate dedicated breast radiologist. All lesions were divided into two groups; with or without microcalcifications on mammograms. In cases without microcalcifications, we recorded the mass, asymmetry, or negative findings on mammography. On MRI, the enhancement pattern was categorized as mass or non-mass-like enhancement. On BSGI, the uptake pattern was analyzed. The histopathological features of the lesions were obtained. Statistical analysis of the sensitivity of each modality was performed using McNemar's test. RESULTS: Thirty-five women with a mean age of 48 years (range, 26-69 years) were enrolled in the study. The total sensitivities of MRI and BSGI in the 35 cases were 91.4% (32 of 35 DCIS) and 68.6% (24 of 35 DCIS), respectively. Eighteen cases with DCIS displayed microcalcifications on mammography, while 17 cases did not. Of these 17 cases without microcalcifications on mammography, 88.2% (15 of 17 DCIS) were detected by MRI and 52.9% (9 of 17 DCIS) by BSGI. Of 18 cases with microcalcifications on mammography, 94.4% (17 of 18 DCIS) were detected by MRI and 83.3% (15 of 19 DCIS) by BSGI. CONCLUSION: MRI showed a higher sensitivity for the detection of calcified and non-calcified DCIS and is more helpful than BSGI in cases without microcalcifications on mammography. SN - 1600-0455 UR - https://www.unboundmedicine.com/medline/citation/24043881/The_diagnostic_sensitivity_of_dynamic_contrast_enhanced_magnetic_resonance_imaging_and_breast_specific_gamma_imaging_in_women_with_calcified_and_non_calcified_DCIS_ L2 - https://journals.sagepub.com/doi/10.1177/0284185113505086?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -