Tags

Type your tag names separated by a space and hit enter

Inhibitors of α-glucosidase and α-amylase from Cyperus rotundus.
Pharm Biol. 2014 Jan; 52(1):74-7.PB

Abstract

CONTEXT

A methanol extract of Cyperus rotundus L. (Cyperaceae) rhizomes showed inhibitory activity against α-glucosidase and α-amylase, two enzymes involve in carbohydrate digestion.

OBJECTIVE

Identification of compounds from C. rotundus rhizomes responsible for the inhibition of α-glucosidase and α-amylase.

MATERIALS AND METHODS

Compounds were identified by a phytochemical investigation using combined chromatographic and spectroscopic methods. α-glucosidase and α-amylase inhibitory activities were evaluated by in vitro enzyme inhibition assays.

RESULTS

A new (2RS,3SR)-3,4',5,6,7,8-hexahydroxyflavane (1), together with three known stilbene dimers cassigarol E (2), scirpusin A (3) and B (4) were isolated. Compound 2 inhibited both α-glucosidase and α-amylase activities while the flavane 1 only showed effect on α-amylase, and compounds 3 and 4 were active on α-glucosidase. All four compounds showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity.

DISCUSSION

The inhibitory activities against α-amylase and α-glucosidase of the C. rotundus rhizomes were reported for the first time. Stilbene dimers are considered as potent inhibitors of α-glucosidase and promising antihyperglycemic agents.

CONCLUSION

The isolated compounds may contribute to the antidiabetic property of C. rotundus.

Authors+Show Affiliations

Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18-Hoang Quoc Viet, Cau Giay, Hanoi , Vietnam and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24044731

Citation

Tran, Hong Hanh Thi, et al. "Inhibitors of Α-glucosidase and Α-amylase From Cyperus Rotundus." Pharmaceutical Biology, vol. 52, no. 1, 2014, pp. 74-7.
Tran HH, Nguyen MC, Le HT, et al. Inhibitors of α-glucosidase and α-amylase from Cyperus rotundus. Pharm Biol. 2014;52(1):74-7.
Tran, H. H., Nguyen, M. C., Le, H. T., Nguyen, T. L., Pham, T. B., Chau, V. M., Nguyen, H. N., & Nguyen, T. D. (2014). Inhibitors of α-glucosidase and α-amylase from Cyperus rotundus. Pharmaceutical Biology, 52(1), 74-7. https://doi.org/10.3109/13880209.2013.814692
Tran HH, et al. Inhibitors of Α-glucosidase and Α-amylase From Cyperus Rotundus. Pharm Biol. 2014;52(1):74-7. PubMed PMID: 24044731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitors of α-glucosidase and α-amylase from Cyperus rotundus. AU - Tran,Hong Hanh Thi, AU - Nguyen,Minh Chau, AU - Le,Hoang Tram, AU - Nguyen,Thi Luyen, AU - Pham,Thanh Binh, AU - Chau,Van Minh, AU - Nguyen,Hoai Nam, AU - Nguyen,Tien Dat, Y1 - 2013/09/18/ PY - 2013/9/19/entrez PY - 2013/9/21/pubmed PY - 2014/9/10/medline SP - 74 EP - 7 JF - Pharmaceutical biology JO - Pharm Biol VL - 52 IS - 1 N2 - CONTEXT: A methanol extract of Cyperus rotundus L. (Cyperaceae) rhizomes showed inhibitory activity against α-glucosidase and α-amylase, two enzymes involve in carbohydrate digestion. OBJECTIVE: Identification of compounds from C. rotundus rhizomes responsible for the inhibition of α-glucosidase and α-amylase. MATERIALS AND METHODS: Compounds were identified by a phytochemical investigation using combined chromatographic and spectroscopic methods. α-glucosidase and α-amylase inhibitory activities were evaluated by in vitro enzyme inhibition assays. RESULTS: A new (2RS,3SR)-3,4',5,6,7,8-hexahydroxyflavane (1), together with three known stilbene dimers cassigarol E (2), scirpusin A (3) and B (4) were isolated. Compound 2 inhibited both α-glucosidase and α-amylase activities while the flavane 1 only showed effect on α-amylase, and compounds 3 and 4 were active on α-glucosidase. All four compounds showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. DISCUSSION: The inhibitory activities against α-amylase and α-glucosidase of the C. rotundus rhizomes were reported for the first time. Stilbene dimers are considered as potent inhibitors of α-glucosidase and promising antihyperglycemic agents. CONCLUSION: The isolated compounds may contribute to the antidiabetic property of C. rotundus. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/24044731/Inhibitors_of_α_glucosidase_and_α_amylase_from_Cyperus_rotundus_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2013.814692 DB - PRIME DP - Unbound Medicine ER -