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Parkinson's disease and history of outdoor occupation.

Abstract

BACKGROUND

Human and animal studies, albeit not fully consistent, suggest that vitamin D may reduce risk of Parkinson's disease (PD). Ultraviolet radiation converts vitamin D precursor to the active form. This study examined the hypothesis that working outdoors is associated with a decreased risk of PD.

METHODS

PD cases were enrolled from Group Health Cooperative, a health maintenance organization in the Puget Sound region in western Washington State, and the University of Washington Neurology Clinic in Seattle. Participants included 447 non-Hispanic Caucasian newly diagnosed PD cases diagnosed between 1992 and 2008 and 578 unrelated neurologically normal controls enrolled in Group Health Cooperative, frequency matched by race/ethnicity, age and gender. Subjects' amount of outdoor work was estimated from self-reported occupational histories. Jobs were categorized by degree of time spent working outdoors. A ten-year lag interval was included to account for disease latency. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression, with adjustment for age, gender, and smoking.

RESULTS

Outdoor work was inversely associated with risk of PD (outdoor only compared to indoor only): OR = 0.74, 95% CI 0.44-1.25. However, there was no trend in relation to portion of the workday spent laboring outdoors and PD risk.

CONCLUSION

Occupational sunlight exposure and other correlates of outdoor work is not likely to have a substantial role in the etiology of PD.

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  • Authors+Show Affiliations

    ,

    United States Army, Madigan Army Medical Center, Department of Preventive Medicine, United States.

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    Source

    Parkinsonism & related disorders 19:12 2013 Dec pg 1164-6

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Female
    Humans
    Male
    Middle Aged
    Occupations
    Parkinson Disease
    Sunlight
    Ultraviolet Rays
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    24044947

    Citation

    Kwon, Elena, et al. "Parkinson's Disease and History of Outdoor Occupation." Parkinsonism & Related Disorders, vol. 19, no. 12, 2013, pp. 1164-6.
    Kwon E, Gallagher LG, Searles Nielsen S, et al. Parkinson's disease and history of outdoor occupation. Parkinsonism Relat Disord. 2013;19(12):1164-6.
    Kwon, E., Gallagher, L. G., Searles Nielsen, S., Franklin, G. M., Littell, C. T., Longstreth, W. T., ... Checkoway, H. (2013). Parkinson's disease and history of outdoor occupation. Parkinsonism & Related Disorders, 19(12), pp. 1164-6. doi:10.1016/j.parkreldis.2013.08.014.
    Kwon E, et al. Parkinson's Disease and History of Outdoor Occupation. Parkinsonism Relat Disord. 2013;19(12):1164-6. PubMed PMID: 24044947.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Parkinson's disease and history of outdoor occupation. AU - Kwon,Elena, AU - Gallagher,Lisa G, AU - Searles Nielsen,Susan, AU - Franklin,Gary M, AU - Littell,Christopher T, AU - Longstreth,W T,Jr AU - Swanson,Phillip D, AU - Checkoway,Harvey, Y1 - 2013/08/30/ PY - 2013/05/07/received PY - 2013/08/14/revised PY - 2013/08/22/accepted PY - 2013/9/19/entrez PY - 2013/9/21/pubmed PY - 2014/8/15/medline KW - Occupation KW - Parkinson's disease KW - Ultraviolet radiation KW - Vitamin D SP - 1164 EP - 6 JF - Parkinsonism & related disorders JO - Parkinsonism Relat. Disord. VL - 19 IS - 12 N2 - BACKGROUND: Human and animal studies, albeit not fully consistent, suggest that vitamin D may reduce risk of Parkinson's disease (PD). Ultraviolet radiation converts vitamin D precursor to the active form. This study examined the hypothesis that working outdoors is associated with a decreased risk of PD. METHODS: PD cases were enrolled from Group Health Cooperative, a health maintenance organization in the Puget Sound region in western Washington State, and the University of Washington Neurology Clinic in Seattle. Participants included 447 non-Hispanic Caucasian newly diagnosed PD cases diagnosed between 1992 and 2008 and 578 unrelated neurologically normal controls enrolled in Group Health Cooperative, frequency matched by race/ethnicity, age and gender. Subjects' amount of outdoor work was estimated from self-reported occupational histories. Jobs were categorized by degree of time spent working outdoors. A ten-year lag interval was included to account for disease latency. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression, with adjustment for age, gender, and smoking. RESULTS: Outdoor work was inversely associated with risk of PD (outdoor only compared to indoor only): OR = 0.74, 95% CI 0.44-1.25. However, there was no trend in relation to portion of the workday spent laboring outdoors and PD risk. CONCLUSION: Occupational sunlight exposure and other correlates of outdoor work is not likely to have a substantial role in the etiology of PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/24044947/Parkinson's_disease_and_history_of_outdoor_occupation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(13)00308-8 DB - PRIME DP - Unbound Medicine ER -