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Prevalence and risk factors for iron-deficiency anemia in very-low-birth-weight preterm infants at 1 year of corrected age.
J Trop Pediatr. 2014 Feb; 60(1):53-60.JT

Abstract

OBJECTIVE

To determine the prevalence of iron-deficiency anemia and iron deficiency at 1 year of corrected age (CA) in preterm very-low-birth-weight infants, and to identify risk factors for iron-deficiency anemia.

METHODS

A cohort of infants with birth weight <1500 g and gestational age <34 weeks on iron prophylaxis were followed up to 12 months' CA. Anemia diagnosis was based on hemoglobin <11 g/dl. Iron deficiency was defined by ferritin levels <10 μg/l, transferrin saturation <10% and mean corpuscular volume <80 fl. Neonatal data and feeding at 6 and 12 months' CA (breastfeeding and/or cow's milk or infant formula); hospitalizations during the first year and weight, head circumference, body mass index and length at 12 months' CA were analyzed.

RESULTS

Prevalence of anemia in 310 participants was 26.5% [95% confidence interval (CI) 21.8-31.6%] and of iron deficiency was 48% (95% CI 39.0-56.9%). Increased consumption of cow's milk at 6 months [relative risk (RR) 1.687; 95% CI 1.146-2.483], lower maternal age (RR 0.953; 95% CI 0.923-0.983), high number of pregnancies (RR 1.256; 95% CI 1.122-1.406) and being born small for gestational age (RR 1.578; 95% CI 1.068-2.331) were independently associated with anemia after adjustments.

CONCLUSIONS

Prevalence of anemia is high at 1 year of CA. Dietary and environmental education strategies may help prevent anemia after discharge.

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Authors+Show Affiliations

Ferri C
Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil 90035-003.
Procianoy RS
No affiliation info available
Silveira RC
No affiliation info available

MeSH

Anemia, Iron-DeficiencyAnimalsBrazilBreast FeedingCattleConfidence IntervalsFemaleFerritinsFollow-Up StudiesHemoglobinsHumansInfantInfant FormulaInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightMaleMaternal AgeMilkPrevalenceRisk FactorsSocioeconomic FactorsSurveys and Questionnaires

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24044971

Citation

Ferri, Cláudia, et al. "Prevalence and Risk Factors for Iron-deficiency Anemia in Very-low-birth-weight Preterm Infants at 1 Year of Corrected Age." Journal of Tropical Pediatrics, vol. 60, no. 1, 2014, pp. 53-60.
Ferri C, Procianoy RS, Silveira RC. Prevalence and risk factors for iron-deficiency anemia in very-low-birth-weight preterm infants at 1 year of corrected age. J Trop Pediatr. 2014;60(1):53-60.
Ferri, C., Procianoy, R. S., & Silveira, R. C. (2014). Prevalence and risk factors for iron-deficiency anemia in very-low-birth-weight preterm infants at 1 year of corrected age. Journal of Tropical Pediatrics, 60(1), 53-60. https://doi.org/10.1093/tropej/fmt077
Ferri C, Procianoy RS, Silveira RC. Prevalence and Risk Factors for Iron-deficiency Anemia in Very-low-birth-weight Preterm Infants at 1 Year of Corrected Age. J Trop Pediatr. 2014;60(1):53-60. PubMed PMID: 24044971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors for iron-deficiency anemia in very-low-birth-weight preterm infants at 1 year of corrected age. AU - Ferri,Cláudia, AU - Procianoy,Renato S, AU - Silveira,Rita C, Y1 - 2013/09/17/ PY - 2013/9/19/entrez PY - 2013/9/21/pubmed PY - 2014/3/26/medline KW - anemia KW - iron deficiency KW - low birth weight KW - premature SP - 53 EP - 60 JF - Journal of tropical pediatrics JO - J Trop Pediatr VL - 60 IS - 1 N2 - OBJECTIVE: To determine the prevalence of iron-deficiency anemia and iron deficiency at 1 year of corrected age (CA) in preterm very-low-birth-weight infants, and to identify risk factors for iron-deficiency anemia. METHODS: A cohort of infants with birth weight <1500 g and gestational age <34 weeks on iron prophylaxis were followed up to 12 months' CA. Anemia diagnosis was based on hemoglobin <11 g/dl. Iron deficiency was defined by ferritin levels <10 μg/l, transferrin saturation <10% and mean corpuscular volume <80 fl. Neonatal data and feeding at 6 and 12 months' CA (breastfeeding and/or cow's milk or infant formula); hospitalizations during the first year and weight, head circumference, body mass index and length at 12 months' CA were analyzed. RESULTS: Prevalence of anemia in 310 participants was 26.5% [95% confidence interval (CI) 21.8-31.6%] and of iron deficiency was 48% (95% CI 39.0-56.9%). Increased consumption of cow's milk at 6 months [relative risk (RR) 1.687; 95% CI 1.146-2.483], lower maternal age (RR 0.953; 95% CI 0.923-0.983), high number of pregnancies (RR 1.256; 95% CI 1.122-1.406) and being born small for gestational age (RR 1.578; 95% CI 1.068-2.331) were independently associated with anemia after adjustments. CONCLUSIONS: Prevalence of anemia is high at 1 year of CA. Dietary and environmental education strategies may help prevent anemia after discharge. SN - 1465-3664 UR - https://www.unboundmedicine.com/medline/citation/24044971/Prevalence_and_risk_factors_for_iron_deficiency_anemia_in_very_low_birth_weight_preterm_infants_at_1_year_of_corrected_age_ L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmt077 DB - PRIME DP - Unbound Medicine ER -