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Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people.
Eur J Clin Nutr 2013; 67(12):1284-90EJ

Abstract

BACKGROUND/OBJECTIVES

Dietary habits are important determinants of individual cardiovascular and metabolic risk. This study investigated the association between dietary patterns and asymptomatic carotid atherosclerosis, defined as the presence of plaques and/or increased intima-media thickness, and metabolic biomarkers of insulin resistance, including the homeostasis model assessment of insulin resistance (HOMA-IR) and the trygliceride/high-density lipoprotein (HDL)-cholesterol (Tg/HDL) ratio in a cohort of adults without known diabetes or atherosclerotic cardiovascular disease.

SUBJECTS/METHODS

Nine hundred and twenty-nine randomly selected participants were cross-sectionally investigated. Each participant answered a food frequency questionnaire, and underwent high-resolution ultrasonographic evaluation of both carotid arteries. Laboratory blood measurements were obtained in a subsample of 507 participants.

RESULTS

A dietary pattern that could be defined as unhealthy (high consumption of soft drinks, fried foods, seed oils, cured meats, butter, red meat and sweets) was identified in 21% of the cohort, whereas 34% of the cohort exhibited a dietary pattern that resembled the Mediterranean diet (high intakes of fruit, milk and cheese, olive oil, vegetables, pasta and bread). Intermediate habits characterized the remaining 45%. After adjusting for age, body mass index (BMI), waist circumference, glycated hemoglobin (HbA1c) and hypertension on treatment, the Mediterranean dietary pattern was associated with significantly lower HOMA-IR (β-coefficient=-0.51; P=0.003). After adjusting for gender, BMI and HbA1c, the unhealthy dietary pattern was associated with a significantly higher Tg/HDL-cholesterol ratio (β-coefficient=0.43; P=0.006). No significant association was found between dietary patterns and carotid atherosclerosis.

CONCLUSIONS

This study suggests that, independent of measures of adiposity, a Mediterranean dietary pattern is associated with lower insulin resistance.

Authors+Show Affiliations

Laboratorio di Nutrizione Clinica-P Giaccone Policlinico, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24045794

Citation

Buscemi, S, et al. "Association of Dietary Patterns With Insulin Resistance and Clinically Silent Carotid Atherosclerosis in Apparently Healthy People." European Journal of Clinical Nutrition, vol. 67, no. 12, 2013, pp. 1284-90.
Buscemi S, Nicolucci A, Mattina A, et al. Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people. Eur J Clin Nutr. 2013;67(12):1284-90.
Buscemi, S., Nicolucci, A., Mattina, A., Rosafio, G., Massenti, F. M., Lucisano, G., ... Rini, G. B. (2013). Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people. European Journal of Clinical Nutrition, 67(12), pp. 1284-90. doi:10.1038/ejcn.2013.172.
Buscemi S, et al. Association of Dietary Patterns With Insulin Resistance and Clinically Silent Carotid Atherosclerosis in Apparently Healthy People. Eur J Clin Nutr. 2013;67(12):1284-90. PubMed PMID: 24045794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people. AU - Buscemi,S, AU - Nicolucci,A, AU - Mattina,A, AU - Rosafio,G, AU - Massenti,F M, AU - Lucisano,G, AU - Galvano,F, AU - Amodio,E, AU - Pellegrini,F, AU - Barile,A M, AU - Maniaci,V, AU - Grosso,G, AU - Verga,S, AU - Sprini,D, AU - Rini,G B, Y1 - 2013/09/18/ PY - 2013/05/06/received PY - 2013/07/27/revised PY - 2013/08/13/accepted PY - 2013/9/19/entrez PY - 2013/9/21/pubmed PY - 2014/7/22/medline SP - 1284 EP - 90 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 67 IS - 12 N2 - BACKGROUND/OBJECTIVES: Dietary habits are important determinants of individual cardiovascular and metabolic risk. This study investigated the association between dietary patterns and asymptomatic carotid atherosclerosis, defined as the presence of plaques and/or increased intima-media thickness, and metabolic biomarkers of insulin resistance, including the homeostasis model assessment of insulin resistance (HOMA-IR) and the trygliceride/high-density lipoprotein (HDL)-cholesterol (Tg/HDL) ratio in a cohort of adults without known diabetes or atherosclerotic cardiovascular disease. SUBJECTS/METHODS: Nine hundred and twenty-nine randomly selected participants were cross-sectionally investigated. Each participant answered a food frequency questionnaire, and underwent high-resolution ultrasonographic evaluation of both carotid arteries. Laboratory blood measurements were obtained in a subsample of 507 participants. RESULTS: A dietary pattern that could be defined as unhealthy (high consumption of soft drinks, fried foods, seed oils, cured meats, butter, red meat and sweets) was identified in 21% of the cohort, whereas 34% of the cohort exhibited a dietary pattern that resembled the Mediterranean diet (high intakes of fruit, milk and cheese, olive oil, vegetables, pasta and bread). Intermediate habits characterized the remaining 45%. After adjusting for age, body mass index (BMI), waist circumference, glycated hemoglobin (HbA1c) and hypertension on treatment, the Mediterranean dietary pattern was associated with significantly lower HOMA-IR (β-coefficient=-0.51; P=0.003). After adjusting for gender, BMI and HbA1c, the unhealthy dietary pattern was associated with a significantly higher Tg/HDL-cholesterol ratio (β-coefficient=0.43; P=0.006). No significant association was found between dietary patterns and carotid atherosclerosis. CONCLUSIONS: This study suggests that, independent of measures of adiposity, a Mediterranean dietary pattern is associated with lower insulin resistance. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/24045794/Association_of_dietary_patterns_with_insulin_resistance_and_clinically_silent_carotid_atherosclerosis_in_apparently_healthy_people_ L2 - http://dx.doi.org/10.1038/ejcn.2013.172 DB - PRIME DP - Unbound Medicine ER -