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Prospective study of Dietary Approaches to Stop Hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging.
Am J Clin Nutr. 2013 Nov; 98(5):1263-71.AJ

Abstract

BACKGROUND

Healthy dietary patterns may protect against age-related cognitive decline, but results of studies have been inconsistent.

OBJECTIVE

We examined associations between Dietary Approaches to Stop Hypertension (DASH)- and Mediterranean-style dietary patterns and age-related cognitive change in a prospective, population-based study.

DESIGN

Participants included 3831 men and women ≥65 y of age who were residents of Cache County, UT, in 1995. Cognitive function was assessed by using the Modified Mini-Mental State Examination (3MS) ≤4 times over 11 y. Diet-adherence scores were computed by summing across the energy-adjusted rank-order of individual food and nutrient components and categorizing participants into quintiles of the distribution of the diet accordance score. Mixed-effects repeated-measures models were used to examine 3MS scores over time across increasing quintiles of dietary accordance scores and individual food components that comprised each score.

RESULTS

The range of rank-order DASH and Mediterranean diet scores was 1661-25,596 and 2407-26,947, respectively. Higher DASH and Mediterranean diet scores were associated with higher average 3MS scores. People in quintile 5 of DASH averaged 0.97 points higher than those in quintile 1 (P = 0.001). The corresponding difference for Mediterranean quintiles was 0.94 (P = 0.001). These differences were consistent over 11 y. Higher intakes of whole grains and nuts and legumes were also associated with higher average 3MS scores [mean quintile 5 compared with 1 differences: 1.19 (P < 0.001), 1.22 (P < 0.001), respectively].

CONCLUSIONS

Higher levels of accordance with both the DASH and Mediterranean dietary patterns were associated with consistently higher levels of cognitive function in elderly men and women over an 11-y period. Whole grains and nuts and legumes were positively associated with higher cognitive functions and may be core neuroprotective foods common to various healthy plant-centered diets around the globe.

Authors+Show Affiliations

Departments of Nutrition, Dietetics, and Food Sciences (HW and RGM), Psychology (JTT), Family Consumer and Human Development (MCN), and Mathematics and Statistics (AC, AQ, AB, and CC) and the Center for Epidemiologic Studies (HW, RGM, CC, JTT, and MCN), Utah State University, Logan, UT, and the Department of Psychiatry and Behavioral Sciences and the Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC (KAW-B).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24047922

Citation

Wengreen, Heidi, et al. "Prospective Study of Dietary Approaches to Stop Hypertension- and Mediterranean-style Dietary Patterns and Age-related Cognitive Change: the Cache County Study On Memory, Health and Aging." The American Journal of Clinical Nutrition, vol. 98, no. 5, 2013, pp. 1263-71.
Wengreen H, Munger RG, Cutler A, et al. Prospective study of Dietary Approaches to Stop Hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. Am J Clin Nutr. 2013;98(5):1263-71.
Wengreen, H., Munger, R. G., Cutler, A., Quach, A., Bowles, A., Corcoran, C., Tschanz, J. T., Norton, M. C., & Welsh-Bohmer, K. A. (2013). Prospective study of Dietary Approaches to Stop Hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. The American Journal of Clinical Nutrition, 98(5), 1263-71. https://doi.org/10.3945/ajcn.112.051276
Wengreen H, et al. Prospective Study of Dietary Approaches to Stop Hypertension- and Mediterranean-style Dietary Patterns and Age-related Cognitive Change: the Cache County Study On Memory, Health and Aging. Am J Clin Nutr. 2013;98(5):1263-71. PubMed PMID: 24047922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of Dietary Approaches to Stop Hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. AU - Wengreen,Heidi, AU - Munger,Ronald G, AU - Cutler,Adele, AU - Quach,Anna, AU - Bowles,Austin, AU - Corcoran,Christopher, AU - Tschanz,Joann T, AU - Norton,Maria C, AU - Welsh-Bohmer,Kathleen A, Y1 - 2013/09/18/ PY - 2013/9/20/entrez PY - 2013/9/21/pubmed PY - 2013/12/18/medline SP - 1263 EP - 71 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 98 IS - 5 N2 - BACKGROUND: Healthy dietary patterns may protect against age-related cognitive decline, but results of studies have been inconsistent. OBJECTIVE: We examined associations between Dietary Approaches to Stop Hypertension (DASH)- and Mediterranean-style dietary patterns and age-related cognitive change in a prospective, population-based study. DESIGN: Participants included 3831 men and women ≥65 y of age who were residents of Cache County, UT, in 1995. Cognitive function was assessed by using the Modified Mini-Mental State Examination (3MS) ≤4 times over 11 y. Diet-adherence scores were computed by summing across the energy-adjusted rank-order of individual food and nutrient components and categorizing participants into quintiles of the distribution of the diet accordance score. Mixed-effects repeated-measures models were used to examine 3MS scores over time across increasing quintiles of dietary accordance scores and individual food components that comprised each score. RESULTS: The range of rank-order DASH and Mediterranean diet scores was 1661-25,596 and 2407-26,947, respectively. Higher DASH and Mediterranean diet scores were associated with higher average 3MS scores. People in quintile 5 of DASH averaged 0.97 points higher than those in quintile 1 (P = 0.001). The corresponding difference for Mediterranean quintiles was 0.94 (P = 0.001). These differences were consistent over 11 y. Higher intakes of whole grains and nuts and legumes were also associated with higher average 3MS scores [mean quintile 5 compared with 1 differences: 1.19 (P < 0.001), 1.22 (P < 0.001), respectively]. CONCLUSIONS: Higher levels of accordance with both the DASH and Mediterranean dietary patterns were associated with consistently higher levels of cognitive function in elderly men and women over an 11-y period. Whole grains and nuts and legumes were positively associated with higher cognitive functions and may be core neuroprotective foods common to various healthy plant-centered diets around the globe. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24047922/Prospective_study_of_Dietary_Approaches_to_Stop_Hypertension__and_Mediterranean_style_dietary_patterns_and_age_related_cognitive_change:_the_Cache_County_Study_on_Memory_Health_and_Aging_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.051276 DB - PRIME DP - Unbound Medicine ER -