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Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.
Complement Ther Med. 2013 Oct; 21(5):473-80.CT

Abstract

BACKGROUND

Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients.

METHODS AND MATERIALS

In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, "Group B" who received olive oil, "Group C" who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-γ and IL-17) were assessed at baseline and after 6 months.

RESULTS

Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention.

CONCLUSION

The co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings.

Authors+Show Affiliations

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; School of Nutrition and Health, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: s.rfirozi@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24050582

Citation

Rezapour-Firouzi, Soheila, et al. "Immunomodulatory and Therapeutic Effects of Hot-nature Diet and Co-supplemented Hemp Seed, Evening Primrose Oils Intervention in Multiple Sclerosis Patients." Complementary Therapies in Medicine, vol. 21, no. 5, 2013, pp. 473-80.
Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, et al. Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med. 2013;21(5):473-80.
Rezapour-Firouzi, S., Arefhosseini, S. R., Mehdi, F., Mehrangiz, E. M., Baradaran, B., Sadeghihokmabad, E., Mostafaei, S., Fazljou, S. M., Torbati, M. A., Sanaie, S., & Zamani, F. (2013). Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complementary Therapies in Medicine, 21(5), 473-80. https://doi.org/10.1016/j.ctim.2013.06.006
Rezapour-Firouzi S, et al. Immunomodulatory and Therapeutic Effects of Hot-nature Diet and Co-supplemented Hemp Seed, Evening Primrose Oils Intervention in Multiple Sclerosis Patients. Complement Ther Med. 2013;21(5):473-80. PubMed PMID: 24050582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. AU - Rezapour-Firouzi,Soheila, AU - Arefhosseini,Seyed Rafie, AU - Mehdi,Farhoudi, AU - Mehrangiz,Ebrahimi-Mamaghani, AU - Baradaran,Behzad, AU - Sadeghihokmabad,Elyar, AU - Mostafaei,Somaiyeh, AU - Fazljou,Seyed Mohammad Bagher, AU - Torbati,Mohammad-ali, AU - Sanaie,Sarvin, AU - Zamani,Fatemeh, Y1 - 2013/07/25/ PY - 2012/12/15/received PY - 2013/05/08/revised PY - 2013/06/16/accepted PY - 2013/9/21/entrez PY - 2013/9/21/pubmed PY - 2014/5/21/medline KW - (FADS2)delta-6-desaturase KW - (STA) stearidonic acid KW - AA KW - ALA KW - CMF KW - CNS KW - D6D KW - DGLA KW - DHA KW - EDSS KW - EFAs KW - EP KW - EPA KW - EPO KW - Evening primrose (Oenothera biennis L.) KW - Expanded Disability Status Scale KW - FAME KW - FAs KW - FDA KW - FR KW - GC KW - GLA KW - HS KW - HSO KW - Hemp seed (Cannabis sativa L.) KW - Hot-nature diet KW - IFN KW - IFN-γ KW - IL KW - Inflammation KW - LA KW - LC-PUFA KW - MS KW - MUFA KW - Mizadj KW - Multiple sclerosis KW - NSRC KW - Neurosciences Research Center KW - PGE KW - PUFA KW - RBCs KW - RRMS KW - SDA KW - SFAs KW - T helper (1-2) KW - TIM KW - Th KW - Traditional Iranian Medicine KW - USFA KW - W/C KW - Warmth/Coldness KW - alpha-linolenic acid KW - arachidonic acid KW - cell membrane fluidity KW - central nervous system KW - dihomo-gamma-linolenic acid KW - docosahexanoic acid (key omega-3) KW - eicosapentaenoic acid KW - essential fatty acids KW - evening primrose KW - evening primrose oil KW - fatty acid methyl esters KW - fatty acids KW - food and drug administration KW - food records KW - gamma linolenic acid KW - gas chromatography KW - hemp seed KW - hemp seed oil KW - interferon (β1b-β1a-β) KW - interferon-γ KW - interleukin-4 KW - linoleic acid (omega-6 family) KW - long chain-polyunsaturated fatty acid KW - monounsaturated fatty acids KW - multiple sclerosis KW - non-quantitative Food Frequency Questionnaires KW - nqFFQ KW - omega-3polyunsaturated fatty acids KW - polyunsaturated fatty acid KW - prostaglandin (E1, E2, E3) KW - red blood cells KW - relapsing remitting multiple sclerosis KW - saturated fatty acids KW - unsaturated fatty acid KW - ω3-PUFAs SP - 473 EP - 80 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 21 IS - 5 N2 - BACKGROUND: Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients. METHODS AND MATERIALS: In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, "Group B" who received olive oil, "Group C" who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-γ and IL-17) were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention. CONCLUSION: The co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/24050582/Immunomodulatory_and_therapeutic_effects_of_Hot_nature_diet_and_co_supplemented_hemp_seed_evening_primrose_oils_intervention_in_multiple_sclerosis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(13)00099-X DB - PRIME DP - Unbound Medicine ER -