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Environmental toxins and Parkinson's disease.
Annu Rev Pharmacol Toxicol 2014; 54:141-64AR

Abstract

Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder that begins in mid to late life and is characterized by motor impairment, autonomic dysfunction, and, in many, psychological and cognitive changes. Recent advances have helped delineate pathogenetic mechanisms, yet the cause of PD in most individuals is unknown. Although at least 15 genes and genetic loci have been associated with PD, identified genetic causes are responsible for only a few percent of cases. Epidemiologic studies have found increased risk of PD associated with exposure to environmental toxicants such as pesticides, solvents, metals, and other pollutants, and many of these compounds recapitulate PD pathology in animal models. This review summarizes the environmental toxicology of PD, highlighting the consistency of observations across cellular, animal, and human studies of PD pathogenesis.

Authors+Show Affiliations

The Parkinson's Institute, Sunnyvale, California 94085; email: sgoldman@thepi.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24050700

Citation

Goldman, Samuel M.. "Environmental Toxins and Parkinson's Disease." Annual Review of Pharmacology and Toxicology, vol. 54, 2014, pp. 141-64.
Goldman SM. Environmental toxins and Parkinson's disease. Annu Rev Pharmacol Toxicol. 2014;54:141-64.
Goldman, S. M. (2014). Environmental toxins and Parkinson's disease. Annual Review of Pharmacology and Toxicology, 54, pp. 141-64. doi:10.1146/annurev-pharmtox-011613-135937.
Goldman SM. Environmental Toxins and Parkinson's Disease. Annu Rev Pharmacol Toxicol. 2014;54:141-64. PubMed PMID: 24050700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental toxins and Parkinson's disease. A1 - Goldman,Samuel M, Y1 - 2013/09/16/ PY - 2013/9/21/entrez PY - 2013/9/21/pubmed PY - 2014/9/3/medline SP - 141 EP - 64 JF - Annual review of pharmacology and toxicology JO - Annu. Rev. Pharmacol. Toxicol. VL - 54 N2 - Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder that begins in mid to late life and is characterized by motor impairment, autonomic dysfunction, and, in many, psychological and cognitive changes. Recent advances have helped delineate pathogenetic mechanisms, yet the cause of PD in most individuals is unknown. Although at least 15 genes and genetic loci have been associated with PD, identified genetic causes are responsible for only a few percent of cases. Epidemiologic studies have found increased risk of PD associated with exposure to environmental toxicants such as pesticides, solvents, metals, and other pollutants, and many of these compounds recapitulate PD pathology in animal models. This review summarizes the environmental toxicology of PD, highlighting the consistency of observations across cellular, animal, and human studies of PD pathogenesis. SN - 1545-4304 UR - https://www.unboundmedicine.com/medline/citation/24050700/Environmental_toxins_and_Parkinson's_disease_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-pharmtox-011613-135937?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -