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Interactive effects of chronic cigarette smoking and age on hippocampal volumes.
Drug Alcohol Depend. 2013 Dec 01; 133(2):704-11.DA

Abstract

BACKGROUND

Previous cross-sectional MRI studies with healthy, young-to-middle-aged adults reported no significant differences between smokers and non-smokers on total hippocampal volume. However, these studies did not specifically test for greater age-related volume loss in the total hippocampus or hippocampal subregions in smokers, and did they did not examine relationships between hippocampal and subfield volumes and episodic learning and memory performance.

METHODS

Healthy, young-to-middle-aged (45 ± 12 years of age) smokers (n=39) and non-smokers (n=43) were compared on total hippocampal and subfield volumes derived from high-resolution 4 Tesla MRI, emphasizing testing for greater age-related volume losses in smokers. Associations between hippocampal volumes and measures of episodic learning and memory were examined.

RESULTS

Smokers showed significantly smaller volumes, as well as greater volume loss with increasing age than non-smokers in the bilateral total hippocampus and multiple subfields. In smokers, greater pack-years were associated with smaller volumes of the total hippocampus, presubiculum, and subiculum. In the entire cohort, performance on measures of learning and memory was related to larger total hippocampal and several subfield volumes, predominately in the left hemisphere.

CONCLUSIONS

Chronic cigarette smoking in this young-to-middle aged cohort was associated with smaller total hippocampal and subfield volumes, which were exacerbated by advancing age. Findings also indicated an adverse smoking dose/duration response (i.e., pack-years) with total hippocampal and select subfield volumes. These hippocampal volume abnormalities in smokers may be related to the deficiencies in episodic learning and memory in young-to-middle-aged smokers reported in previous studies.

Authors+Show Affiliations

Center for Imaging of Neurodegenerative Diseases (CIND), San Francisco VA Medical Center, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: timothy.durazzo@ucsf.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24051060

Citation

Durazzo, Timothy C., et al. "Interactive Effects of Chronic Cigarette Smoking and Age On Hippocampal Volumes." Drug and Alcohol Dependence, vol. 133, no. 2, 2013, pp. 704-11.
Durazzo TC, Meyerhoff DJ, Nixon SJ. Interactive effects of chronic cigarette smoking and age on hippocampal volumes. Drug Alcohol Depend. 2013;133(2):704-11.
Durazzo, T. C., Meyerhoff, D. J., & Nixon, S. J. (2013). Interactive effects of chronic cigarette smoking and age on hippocampal volumes. Drug and Alcohol Dependence, 133(2), 704-11. https://doi.org/10.1016/j.drugalcdep.2013.08.020
Durazzo TC, Meyerhoff DJ, Nixon SJ. Interactive Effects of Chronic Cigarette Smoking and Age On Hippocampal Volumes. Drug Alcohol Depend. 2013 Dec 1;133(2):704-11. PubMed PMID: 24051060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactive effects of chronic cigarette smoking and age on hippocampal volumes. AU - Durazzo,Timothy C, AU - Meyerhoff,Dieter J, AU - Nixon,Sara Jo, Y1 - 2013/09/02/ PY - 2013/07/24/received PY - 2013/08/23/revised PY - 2013/08/23/accepted PY - 2013/9/21/entrez PY - 2013/9/21/pubmed PY - 2014/6/24/medline KW - Aging KW - Cigarette smoking KW - Hippocampal subfields KW - Hippocampus KW - Learning and memory KW - MRI SP - 704 EP - 11 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 133 IS - 2 N2 - BACKGROUND: Previous cross-sectional MRI studies with healthy, young-to-middle-aged adults reported no significant differences between smokers and non-smokers on total hippocampal volume. However, these studies did not specifically test for greater age-related volume loss in the total hippocampus or hippocampal subregions in smokers, and did they did not examine relationships between hippocampal and subfield volumes and episodic learning and memory performance. METHODS: Healthy, young-to-middle-aged (45 ± 12 years of age) smokers (n=39) and non-smokers (n=43) were compared on total hippocampal and subfield volumes derived from high-resolution 4 Tesla MRI, emphasizing testing for greater age-related volume losses in smokers. Associations between hippocampal volumes and measures of episodic learning and memory were examined. RESULTS: Smokers showed significantly smaller volumes, as well as greater volume loss with increasing age than non-smokers in the bilateral total hippocampus and multiple subfields. In smokers, greater pack-years were associated with smaller volumes of the total hippocampus, presubiculum, and subiculum. In the entire cohort, performance on measures of learning and memory was related to larger total hippocampal and several subfield volumes, predominately in the left hemisphere. CONCLUSIONS: Chronic cigarette smoking in this young-to-middle aged cohort was associated with smaller total hippocampal and subfield volumes, which were exacerbated by advancing age. Findings also indicated an adverse smoking dose/duration response (i.e., pack-years) with total hippocampal and select subfield volumes. These hippocampal volume abnormalities in smokers may be related to the deficiencies in episodic learning and memory in young-to-middle-aged smokers reported in previous studies. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/24051060/Interactive_effects_of_chronic_cigarette_smoking_and_age_on_hippocampal_volumes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(13)00336-0 DB - PRIME DP - Unbound Medicine ER -