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Increased breast cancer risk for patients with multiple sclerosis: a nationwide population-based cohort study.
Eur J Neurol. 2014 Feb; 21(2):238-44.EJ

Abstract

BACKGROUND AND PURPOSE

Studies have suggested that multiple sclerosis (MS) might be linked to an overall reduced cancer rate, but a positive relationship is also found for several types of cancer. This study determines whether MS is associated with cancer risk in Taiwan.

METHODS

Data from the National Health Insurance System of Taiwan were used to assess this issue. The MS cohort included 1292 patients, and each patient was randomly frequency-matched with four participants without MS, based on their age, sex and index year (control cohort). Cox proportional hazards regression analysis was conducted to estimate the influence of MS on cancer risk.

RESULTS

A significantly higher risk of developing overall cancer was found amongst the MS cohort compared with the control cohort [adjusted hazard ratio (HR) 1.85, 95% confidence interval (CI) 1.26-2.74], as well as breast cancer (adjusted HR 2.23, 95% CI 1.11-4.46).

CONCLUSIONS

The nationwide population-based cohort study revealed that Taiwanese patients with MS have a higher risk of developing overall cancer types and breast cancer in particular.

Authors+Show Affiliations

Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24053223

Citation

Sun, L-M, et al. "Increased Breast Cancer Risk for Patients With Multiple Sclerosis: a Nationwide Population-based Cohort Study." European Journal of Neurology, vol. 21, no. 2, 2014, pp. 238-44.
Sun LM, Lin CL, Chung CJ, et al. Increased breast cancer risk for patients with multiple sclerosis: a nationwide population-based cohort study. Eur J Neurol. 2014;21(2):238-44.
Sun, L. M., Lin, C. L., Chung, C. J., Liang, J. A., Sung, F. C., & Kao, C. H. (2014). Increased breast cancer risk for patients with multiple sclerosis: a nationwide population-based cohort study. European Journal of Neurology, 21(2), 238-44. https://doi.org/10.1111/ene.12267
Sun LM, et al. Increased Breast Cancer Risk for Patients With Multiple Sclerosis: a Nationwide Population-based Cohort Study. Eur J Neurol. 2014;21(2):238-44. PubMed PMID: 24053223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased breast cancer risk for patients with multiple sclerosis: a nationwide population-based cohort study. AU - Sun,L-M, AU - Lin,C-L, AU - Chung,C-J, AU - Liang,J-A, AU - Sung,F-C, AU - Kao,C-H, Y1 - 2013/09/19/ PY - 2013/04/28/received PY - 2013/08/23/accepted PY - 2013/9/24/entrez PY - 2013/9/24/pubmed PY - 2014/10/29/medline KW - breast cancer KW - cancer KW - cohort study KW - multiple sclerosis SP - 238 EP - 44 JF - European journal of neurology JO - Eur. J. Neurol. VL - 21 IS - 2 N2 - BACKGROUND AND PURPOSE: Studies have suggested that multiple sclerosis (MS) might be linked to an overall reduced cancer rate, but a positive relationship is also found for several types of cancer. This study determines whether MS is associated with cancer risk in Taiwan. METHODS: Data from the National Health Insurance System of Taiwan were used to assess this issue. The MS cohort included 1292 patients, and each patient was randomly frequency-matched with four participants without MS, based on their age, sex and index year (control cohort). Cox proportional hazards regression analysis was conducted to estimate the influence of MS on cancer risk. RESULTS: A significantly higher risk of developing overall cancer was found amongst the MS cohort compared with the control cohort [adjusted hazard ratio (HR) 1.85, 95% confidence interval (CI) 1.26-2.74], as well as breast cancer (adjusted HR 2.23, 95% CI 1.11-4.46). CONCLUSIONS: The nationwide population-based cohort study revealed that Taiwanese patients with MS have a higher risk of developing overall cancer types and breast cancer in particular. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/24053223/Increased_breast_cancer_risk_for_patients_with_multiple_sclerosis:_a_nationwide_population_based_cohort_study_ L2 - https://doi.org/10.1111/ene.12267 DB - PRIME DP - Unbound Medicine ER -