Tags

Type your tag names separated by a space and hit enter

The role of oncoplastic breast surgery in the management of breast cancer treated with primary chemotherapy.
Breast 2013; 22(6):1189-93B

Abstract

OBJECTIVE

The purpose of this study was to evaluate the benefit of Oncoplastic Breast Conserving Surgery (BCS) compared to standard BCS after primary CT, in terms of oncologic safety and cosmetic outcomes.

BACKGROUND

The development of new drugs has led to greater use of primary chemotherapy (CT) for bulky breast cancer (BC) and has allowed wider indications for conservative surgery.

PATIENTS AND METHODS

We identified 259 patients consecutively treated with BCS for primary BC from January 2002 to November 2010. All patients had undergone Oncoplastic Breast Surgery (OBS) or standard BCS after primary CT. Mastectomy rates, and oncological and cosmetic outcomes were compared.

RESULTS

A total of 45 OBS and 214 standard BCS were analyzed. The median tumor size was 40 mm in the two groups (p = 0.66). The median operative specimen volumes were larger in the OBS group than in the standard group (respectively, 180 cm3 and 98 cm3, p < 0.0001). Re-excision (9% vs. 2%) and mastectomy (24% vs. 18%) rates were similar (p = 0.22 and p = 0.30) in the standard BCS group and in the OBS group respectively. At a median follow-up of 46 months, local relapse (p = 0.23) and distant relapse (p = 0.35) rates were similar.

CONCLUSION

OBS allows excision of larger volumes of residual tumor after primary CT. OBS outcomes results were similar to those of standard BCS. Oncoplastic Breast Conserving Surgery (BCS) after primary chemotherapy allows wider breast resection than standard BCS. Survival and relapse probabilities are similar in both groups.

Authors+Show Affiliations

Department of Breast and Plastic Surgery, Institut Gustave Roussy, Villejuif, France. Electronic address: chafika.mazouni@igr.fr.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24054903

Citation

Mazouni, Chafika, et al. "The Role of Oncoplastic Breast Surgery in the Management of Breast Cancer Treated With Primary Chemotherapy." Breast (Edinburgh, Scotland), vol. 22, no. 6, 2013, pp. 1189-93.
Mazouni C, Naveau A, Kane A, et al. The role of oncoplastic breast surgery in the management of breast cancer treated with primary chemotherapy. Breast. 2013;22(6):1189-93.
Mazouni, C., Naveau, A., Kane, A., Dunant, A., Garbay, J. R., Leymarie, N., ... Rimareix, F. (2013). The role of oncoplastic breast surgery in the management of breast cancer treated with primary chemotherapy. Breast (Edinburgh, Scotland), 22(6), pp. 1189-93. doi:10.1016/j.breast.2013.07.055.
Mazouni C, et al. The Role of Oncoplastic Breast Surgery in the Management of Breast Cancer Treated With Primary Chemotherapy. Breast. 2013;22(6):1189-93. PubMed PMID: 24054903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of oncoplastic breast surgery in the management of breast cancer treated with primary chemotherapy. AU - Mazouni,Chafika, AU - Naveau,Alix, AU - Kane,Aminata, AU - Dunant,Ariane, AU - Garbay,Jean-Rémi, AU - Leymarie,Nicolas, AU - Sarfati,Benjamin, AU - Delaloge,Suzette, AU - Rimareix,Françoise, Y1 - 2013/09/19/ PY - 2013/03/28/received PY - 2013/07/04/revised PY - 2013/07/20/accepted PY - 2013/9/24/entrez PY - 2013/9/24/pubmed PY - 2014/11/2/medline KW - Breast cancer KW - Breast conserving surgery KW - Mammaplasty KW - Mastectomy KW - Neoadjuvant chemotherapy SP - 1189 EP - 93 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 22 IS - 6 N2 - OBJECTIVE: The purpose of this study was to evaluate the benefit of Oncoplastic Breast Conserving Surgery (BCS) compared to standard BCS after primary CT, in terms of oncologic safety and cosmetic outcomes. BACKGROUND: The development of new drugs has led to greater use of primary chemotherapy (CT) for bulky breast cancer (BC) and has allowed wider indications for conservative surgery. PATIENTS AND METHODS: We identified 259 patients consecutively treated with BCS for primary BC from January 2002 to November 2010. All patients had undergone Oncoplastic Breast Surgery (OBS) or standard BCS after primary CT. Mastectomy rates, and oncological and cosmetic outcomes were compared. RESULTS: A total of 45 OBS and 214 standard BCS were analyzed. The median tumor size was 40 mm in the two groups (p = 0.66). The median operative specimen volumes were larger in the OBS group than in the standard group (respectively, 180 cm3 and 98 cm3, p < 0.0001). Re-excision (9% vs. 2%) and mastectomy (24% vs. 18%) rates were similar (p = 0.22 and p = 0.30) in the standard BCS group and in the OBS group respectively. At a median follow-up of 46 months, local relapse (p = 0.23) and distant relapse (p = 0.35) rates were similar. CONCLUSION: OBS allows excision of larger volumes of residual tumor after primary CT. OBS outcomes results were similar to those of standard BCS. Oncoplastic Breast Conserving Surgery (BCS) after primary chemotherapy allows wider breast resection than standard BCS. Survival and relapse probabilities are similar in both groups. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/24054903/The_role_of_oncoplastic_breast_surgery_in_the_management_of_breast_cancer_treated_with_primary_chemotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(13)00231-2 DB - PRIME DP - Unbound Medicine ER -