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Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.
Exp Gerontol. 2013 Nov; 48(11):1369-77.EG

Abstract

Valeriana officinalis is used in herbal medicine of many cultures as mild sedatives and tranquilizers. In this study, we investigated the effects of extract from valerian root extracts and its major component, valerenic acid on memory function, cell proliferation, neuroblast differentiation, serum corticosterone, and lipid peroxidation in adult and aged mice. For the aging model, D-galactose (100 mg/kg) was administered subcutaneously to 6-week-old male mice for 10 weeks. At 13 weeks of age, valerian root extracts (100 mg/kg) or valerenic acid (340 μg/kg) was administered orally to control and D-galactose-treated mice for 3 weeks. The dosage of valerenic acid (340 μg/kg), which is the active ingredient of valerian root extract, was determined by the content of valerenic acid in valerian root extract (3.401±0.066 mg/g) measured by HPLC. The administration of valerian root extract and valerenic acid significantly improved the preferential exploration of new objects in novel object recognition test and the escape latency, swimming speeds, platform crossings, and spatial preference for the target quadrant in Morris water maze test compared to the D-galactose-treated mice. Cell proliferation and neuroblast differentiation were significantly decreased, while serum corticosterone level and lipid peroxidation in hippocampus were significantly increased in the D-galactose-treated group compared to that in the control group. The administration of valerian root extract significantly ameliorated these changes in the dentate gyrus of both control and D-galactose-treated groups. In addition, valerenic acid also mitigated the D-galactose-induced reduction of these changes. These results indicate that valerian root extract and valerenic acid enhance cognitive function, promote cell proliferation and neuroblast differentiation, and reduce serum corticosterone and lipid peroxidation in aged mice.

Authors+Show Affiliations

Department of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24055511

Citation

Nam, Sung Min, et al. "Valeriana Officinalis Extract and Its Main Component, Valerenic Acid, Ameliorate D-galactose-induced Reductions in Memory, Cell Proliferation, and Neuroblast Differentiation By Reducing Corticosterone Levels and Lipid Peroxidation." Experimental Gerontology, vol. 48, no. 11, 2013, pp. 1369-77.
Nam SM, Choi JH, Yoo DY, et al. Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. Exp Gerontol. 2013;48(11):1369-77.
Nam, S. M., Choi, J. H., Yoo, D. Y., Kim, W., Jung, H. Y., Kim, J. W., Kang, S. Y., Park, J., Kim, D. W., Kim, W. J., Yoon, Y. S., & Hwang, I. K. (2013). Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. Experimental Gerontology, 48(11), 1369-77. https://doi.org/10.1016/j.exger.2013.09.002
Nam SM, et al. Valeriana Officinalis Extract and Its Main Component, Valerenic Acid, Ameliorate D-galactose-induced Reductions in Memory, Cell Proliferation, and Neuroblast Differentiation By Reducing Corticosterone Levels and Lipid Peroxidation. Exp Gerontol. 2013;48(11):1369-77. PubMed PMID: 24055511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. AU - Nam,Sung Min, AU - Choi,Jung Hoon, AU - Yoo,Dae Young, AU - Kim,Woosuk, AU - Jung,Hyo Young, AU - Kim,Jong Whi, AU - Kang,Soo-Yong, AU - Park,Jaeil, AU - Kim,Dong-Woo, AU - Kim,Wan Jae, AU - Yoon,Yeo Sung, AU - Hwang,In Koo, Y1 - 2013/09/18/ PY - 2013/03/02/received PY - 2013/09/09/revised PY - 2013/09/11/accepted PY - 2013/9/24/entrez PY - 2013/9/24/pubmed PY - 2014/6/3/medline KW - Aging KW - Hippocampus KW - Lipid peroxidation KW - Neurogenesis KW - Serum corticosterone KW - Valerian root extract SP - 1369 EP - 77 JF - Experimental gerontology JO - Exp Gerontol VL - 48 IS - 11 N2 - Valeriana officinalis is used in herbal medicine of many cultures as mild sedatives and tranquilizers. In this study, we investigated the effects of extract from valerian root extracts and its major component, valerenic acid on memory function, cell proliferation, neuroblast differentiation, serum corticosterone, and lipid peroxidation in adult and aged mice. For the aging model, D-galactose (100 mg/kg) was administered subcutaneously to 6-week-old male mice for 10 weeks. At 13 weeks of age, valerian root extracts (100 mg/kg) or valerenic acid (340 μg/kg) was administered orally to control and D-galactose-treated mice for 3 weeks. The dosage of valerenic acid (340 μg/kg), which is the active ingredient of valerian root extract, was determined by the content of valerenic acid in valerian root extract (3.401±0.066 mg/g) measured by HPLC. The administration of valerian root extract and valerenic acid significantly improved the preferential exploration of new objects in novel object recognition test and the escape latency, swimming speeds, platform crossings, and spatial preference for the target quadrant in Morris water maze test compared to the D-galactose-treated mice. Cell proliferation and neuroblast differentiation were significantly decreased, while serum corticosterone level and lipid peroxidation in hippocampus were significantly increased in the D-galactose-treated group compared to that in the control group. The administration of valerian root extract significantly ameliorated these changes in the dentate gyrus of both control and D-galactose-treated groups. In addition, valerenic acid also mitigated the D-galactose-induced reduction of these changes. These results indicate that valerian root extract and valerenic acid enhance cognitive function, promote cell proliferation and neuroblast differentiation, and reduce serum corticosterone and lipid peroxidation in aged mice. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/24055511/Valeriana_officinalis_extract_and_its_main_component_valerenic_acid_ameliorate_D_galactose_induced_reductions_in_memory_cell_proliferation_and_neuroblast_differentiation_by_reducing_corticosterone_levels_and_lipid_peroxidation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(13)00283-0 DB - PRIME DP - Unbound Medicine ER -