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Early visuomotor integration processes induce LTP/LTD-like plasticity in the human motor cortex.
Cereb Cortex 2015; 25(3):703-12CC

Abstract

To investigate whether visuomotor integration processes induce long-term potentiation (LTP) and depression (LTD)-like plasticity in the primary motor cortex (M1), we designed a new paired associative stimulation (PAS) protocol coupling left primary visual area (V1) activation achieved by hemifield visual evoked potentials (VEPs) and transcranial magnetic stimulation (TMS) over the left M1, at specific interstimulus intervals (ISIs), delivered at 1 Hz (V-PAS). Before and after V-PAS, we measured motor evoked potentials (MEPs). To clarify the mechanisms underlying V-PAS, we tested the effect of 1-Hz repetitive TMS (rTMS), 0.25-Hz V-PAS and rTMS, and a shorter 0.25-Hz V-PAS protocol. To examine V-PAS with contralateral V1 activation, we delivered V-PAS activating the right V1. To clarify whether V-PAS increases V1 activity or parieto- and premotor-to-M1 connectivity, before and after V-PAS, we examined VEPs and MEPs evoked by paired-pulse techniques. V-PAS increased, decreased, or left MEPs unchanged according to the ISI used. After 1-Hz rTMS MEPs decreased. Although 0.25-Hz rTMS elicited no aftereffect, 0.25-Hz V-PAS modulated MEPs according to the ISI used. The short 0.25-Hz V-PAS protocol left MEPs unchanged. Contralateral V-PAS inhibited MEPs. After V-PAS, VEPs remained unchanged and the premotor-to-M1 inhibitory connections decreased. V-PAS induces M1 LTP/LTD-like plasticity by activating premotor-to-motor connections.

Authors+Show Affiliations

IRCCS Neuromed Institute, Pozzilli (IS), Italy.IRCCS Neuromed Institute, Pozzilli (IS), Italy.Department of Neurology and Psychiatry.Department of Physiology and Pharmacology, "Sapienza" University of Rome, 00185 Rome, Italy.IRCCS Neuromed Institute, Pozzilli (IS), Italy Department of Neurology and Psychiatry.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24057659

Citation

Suppa, A, et al. "Early Visuomotor Integration Processes Induce LTP/LTD-like Plasticity in the Human Motor Cortex." Cerebral Cortex (New York, N.Y. : 1991), vol. 25, no. 3, 2015, pp. 703-12.
Suppa A, Li Voti P, Rocchi L, et al. Early visuomotor integration processes induce LTP/LTD-like plasticity in the human motor cortex. Cereb Cortex. 2015;25(3):703-12.
Suppa, A., Li Voti, P., Rocchi, L., Papazachariadis, O., & Berardelli, A. (2015). Early visuomotor integration processes induce LTP/LTD-like plasticity in the human motor cortex. Cerebral Cortex (New York, N.Y. : 1991), 25(3), pp. 703-12. doi:10.1093/cercor/bht264.
Suppa A, et al. Early Visuomotor Integration Processes Induce LTP/LTD-like Plasticity in the Human Motor Cortex. Cereb Cortex. 2015;25(3):703-12. PubMed PMID: 24057659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early visuomotor integration processes induce LTP/LTD-like plasticity in the human motor cortex. AU - Suppa,A, AU - Li Voti,P, AU - Rocchi,L, AU - Papazachariadis,O, AU - Berardelli,A, Y1 - 2013/09/20/ PY - 2013/9/24/entrez PY - 2013/9/24/pubmed PY - 2015/10/28/medline KW - paired associative stimulation KW - primary motor cortex KW - rTMS KW - visual evoked potentials KW - visuomotor integration SP - 703 EP - 12 JF - Cerebral cortex (New York, N.Y. : 1991) JO - Cereb. Cortex VL - 25 IS - 3 N2 - To investigate whether visuomotor integration processes induce long-term potentiation (LTP) and depression (LTD)-like plasticity in the primary motor cortex (M1), we designed a new paired associative stimulation (PAS) protocol coupling left primary visual area (V1) activation achieved by hemifield visual evoked potentials (VEPs) and transcranial magnetic stimulation (TMS) over the left M1, at specific interstimulus intervals (ISIs), delivered at 1 Hz (V-PAS). Before and after V-PAS, we measured motor evoked potentials (MEPs). To clarify the mechanisms underlying V-PAS, we tested the effect of 1-Hz repetitive TMS (rTMS), 0.25-Hz V-PAS and rTMS, and a shorter 0.25-Hz V-PAS protocol. To examine V-PAS with contralateral V1 activation, we delivered V-PAS activating the right V1. To clarify whether V-PAS increases V1 activity or parieto- and premotor-to-M1 connectivity, before and after V-PAS, we examined VEPs and MEPs evoked by paired-pulse techniques. V-PAS increased, decreased, or left MEPs unchanged according to the ISI used. After 1-Hz rTMS MEPs decreased. Although 0.25-Hz rTMS elicited no aftereffect, 0.25-Hz V-PAS modulated MEPs according to the ISI used. The short 0.25-Hz V-PAS protocol left MEPs unchanged. Contralateral V-PAS inhibited MEPs. After V-PAS, VEPs remained unchanged and the premotor-to-M1 inhibitory connections decreased. V-PAS induces M1 LTP/LTD-like plasticity by activating premotor-to-motor connections. SN - 1460-2199 UR - https://www.unboundmedicine.com/medline/citation/24057659/Early_visuomotor_integration_processes_induce_LTP/LTD_like_plasticity_in_the_human_motor_cortex_ L2 - https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bht264 DB - PRIME DP - Unbound Medicine ER -