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Non-high-density lipoprotein cholesterol on the risks of stroke: a result from the Kailuan study.
PLoS One 2013; 8(9):e74634Plos

Abstract

AIMS

To prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of stroke and its subtypes.

METHODS

A total of 95,916 participants (18-98 years old; 76,354 men and 19,562 women) from a Chinese urban community who were free of myocardial infarction and stroke at baseline time point (2006-2007) were eligible and enrolled in the study. The serum non-HDLC levels of participants were determined by subtracting the high-density lipoprotein cholesterol (HDLC) from total serum cholesterol. The primary outcome was the first occurrence of stroke, which was diagnosed according to the World Health Organization criteria and classified into three subtypes: ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. The Cox proportional hazards models were used to estimate risk of stroke and its subtypes.

RESULTS

During the four-year follow-up, we identified 1614 stroke events (1,156 ischemic, 416 intracerebral hemorrhagic and 42 subarachnoid hemorrhagic). Statistical analyses showed that hazard ratios (HR) (95% Confidence Interval: CI) of serum Non-HDLC level for total and subtypes of stroke were: 1.08 (1.03-1.12) (total), 1.10 (1.05-1.16) (ischemic), 1.03 (0.96-1.10) (intracerebral hemorrhage) and 0.83 (0.66-1.05) (subarachnoid hemorrhage). HR for non-HDLC refers to the increase per each 20 mg/dl. For total and ischemic stroke, the risks were significantly higher in the fourth and fifth quintiles of non-HDLC concentrations compared to the first quintile after adjusting the confounding factors (total stroke: 4(th) quintile HR=1.33 (1.12-1.59); 5(th) quintile HR = 1.36 (1.15-1.62); ischemic stroke: 4(th) quintile HR =1.34 (1.09-1.66); 5(th) quintile HR = 1.53 (1.24-1.88)).

CONCLUSIONS

Our data suggest that serum non-HDLC level is an independent risk factor for total and ischemic stroke, and that higher serum non-HDLC concentrations are associated with increased risks for total stroke and ischemic stroke, but not for intracerebral and subarachnoid hemorrhage.

Authors+Show Affiliations

Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24058611

Citation

Wu, Jianwei, et al. "Non-high-density Lipoprotein Cholesterol On the Risks of Stroke: a Result From the Kailuan Study." PloS One, vol. 8, no. 9, 2013, pp. e74634.
Wu J, Chen S, Zhou Y, et al. Non-high-density lipoprotein cholesterol on the risks of stroke: a result from the Kailuan study. PLoS ONE. 2013;8(9):e74634.
Wu, J., Chen, S., Zhou, Y., Wang, C., Wang, A., Zhang, Q., ... Zhao, X. (2013). Non-high-density lipoprotein cholesterol on the risks of stroke: a result from the Kailuan study. PloS One, 8(9), pp. e74634. doi:10.1371/journal.pone.0074634.
Wu J, et al. Non-high-density Lipoprotein Cholesterol On the Risks of Stroke: a Result From the Kailuan Study. PLoS ONE. 2013;8(9):e74634. PubMed PMID: 24058611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-high-density lipoprotein cholesterol on the risks of stroke: a result from the Kailuan study. AU - Wu,Jianwei, AU - Chen,Shengyun, AU - Zhou,Yong, AU - Wang,Chunxue, AU - Wang,Anxin, AU - Zhang,Qian, AU - Gao,Xiang, AU - Hu,Haitao, AU - Wu,Shouling, AU - Zhao,Xingquan, Y1 - 2013/09/10/ PY - 2013/03/14/received PY - 2013/08/03/accepted PY - 2013/9/24/entrez PY - 2013/9/24/pubmed PY - 2014/6/17/medline SP - e74634 EP - e74634 JF - PloS one JO - PLoS ONE VL - 8 IS - 9 N2 - AIMS: To prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of stroke and its subtypes. METHODS: A total of 95,916 participants (18-98 years old; 76,354 men and 19,562 women) from a Chinese urban community who were free of myocardial infarction and stroke at baseline time point (2006-2007) were eligible and enrolled in the study. The serum non-HDLC levels of participants were determined by subtracting the high-density lipoprotein cholesterol (HDLC) from total serum cholesterol. The primary outcome was the first occurrence of stroke, which was diagnosed according to the World Health Organization criteria and classified into three subtypes: ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. The Cox proportional hazards models were used to estimate risk of stroke and its subtypes. RESULTS: During the four-year follow-up, we identified 1614 stroke events (1,156 ischemic, 416 intracerebral hemorrhagic and 42 subarachnoid hemorrhagic). Statistical analyses showed that hazard ratios (HR) (95% Confidence Interval: CI) of serum Non-HDLC level for total and subtypes of stroke were: 1.08 (1.03-1.12) (total), 1.10 (1.05-1.16) (ischemic), 1.03 (0.96-1.10) (intracerebral hemorrhage) and 0.83 (0.66-1.05) (subarachnoid hemorrhage). HR for non-HDLC refers to the increase per each 20 mg/dl. For total and ischemic stroke, the risks were significantly higher in the fourth and fifth quintiles of non-HDLC concentrations compared to the first quintile after adjusting the confounding factors (total stroke: 4(th) quintile HR=1.33 (1.12-1.59); 5(th) quintile HR = 1.36 (1.15-1.62); ischemic stroke: 4(th) quintile HR =1.34 (1.09-1.66); 5(th) quintile HR = 1.53 (1.24-1.88)). CONCLUSIONS: Our data suggest that serum non-HDLC level is an independent risk factor for total and ischemic stroke, and that higher serum non-HDLC concentrations are associated with increased risks for total stroke and ischemic stroke, but not for intracerebral and subarachnoid hemorrhage. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24058611/Non_high_density_lipoprotein_cholesterol_on_the_risks_of_stroke:_a_result_from_the_Kailuan_study_ L2 - http://dx.plos.org/10.1371/journal.pone.0074634 DB - PRIME DP - Unbound Medicine ER -