Tags

Type your tag names separated by a space and hit enter

Two new stereoisomeric antioxidant triterpenes from Potentilla fulgens.
Fitoterapia. 2013 Dec; 91:290-297.F

Abstract

The roots of Potentilla fulgens have been used for a long time as a folk remedy for many ailments without having information on its pharmacological action. Of the various extracts prepared by partitioning of the methanol extract, the ethyl acetate fraction was found to possess better antioxidant and cytotoxic activities. The degree of reduction in cloning efficiencies of MCF-7 cell lines was more with ethyl acetate than with hexane fraction of the root-extract. Hence, this fraction was further purified and nine compounds, including two new ursane type triterpenoids Fulgic acid A (4) and Fulgic acid B (5), were identified and characterized. Other compounds were identified as ursolic acid, euscaphic acid, corosolic acid, epicatechin, catechin, p-hydroxybenzaldehyde and gallic acid. Chemical structures were elucidated by spectroscopic methods, especially ESIHRMS and 2D NMR techniques. The new compounds showed good antioxidant activity and therefore this plant can be a source of natural antioxidants.

Links

Publisher Full Text

Authors+Show Affiliations

Choudhary A
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, 160062 Punjab, India.
Mittal AK
Department of Pharmaceutical Technology Biotechnology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, 160062 Punjab, India.
Radhika M
Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong, 793002 Meghalaya, India.
Tripathy D
Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong, 793002 Meghalaya, India.
Chatterjee A
Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong, 793002 Meghalaya, India.
Banerjee UC
Department of Pharmaceutical Technology Biotechnology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, 160062 Punjab, India.
Singh IP
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, 160062 Punjab, India. Electronic address: ipsingh@niper.ac.in.

MeSH

Antineoplastic Agents, PhytogenicAntioxidantsBenzaldehydesCatechinGallic AcidHumansMCF-7 CellsMolecular StructurePlant ExtractsPlant RootsPotentillaTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24060908

Citation

Choudhary, Alka, et al. "Two New Stereoisomeric Antioxidant Triterpenes From Potentilla Fulgens." Fitoterapia, vol. 91, 2013, pp. 290-297.
Choudhary A, Mittal AK, Radhika M, et al. Two new stereoisomeric antioxidant triterpenes from Potentilla fulgens. Fitoterapia. 2013;91:290-297.
Choudhary, A., Mittal, A. K., Radhika, M., Tripathy, D., Chatterjee, A., Banerjee, U. C., & Singh, I. P. (2013). Two new stereoisomeric antioxidant triterpenes from Potentilla fulgens. Fitoterapia, 91, 290-297. https://doi.org/10.1016/j.fitote.2013.09.008
Choudhary A, et al. Two New Stereoisomeric Antioxidant Triterpenes From Potentilla Fulgens. Fitoterapia. 2013;91:290-297. PubMed PMID: 24060908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new stereoisomeric antioxidant triterpenes from Potentilla fulgens. AU - Choudhary,Alka, AU - Mittal,Amit Kumar, AU - Radhika,Manukonda, AU - Tripathy,Debabrata, AU - Chatterjee,Anupam, AU - Banerjee,Uttam Chand, AU - Singh,Inder Pal, Y1 - 2013/09/21/ PY - 2013/07/01/received PY - 2013/09/09/revised PY - 2013/09/14/accepted PY - 2013/9/25/entrez PY - 2013/9/26/pubmed PY - 2014/6/3/medline KW - Antioxidants KW - Fulgic acids KW - Potentilla fulgens KW - Rosaceae KW - Triterpenes KW - Ursane SP - 290 EP - 297 JF - Fitoterapia JO - Fitoterapia VL - 91 N2 - The roots of Potentilla fulgens have been used for a long time as a folk remedy for many ailments without having information on its pharmacological action. Of the various extracts prepared by partitioning of the methanol extract, the ethyl acetate fraction was found to possess better antioxidant and cytotoxic activities. The degree of reduction in cloning efficiencies of MCF-7 cell lines was more with ethyl acetate than with hexane fraction of the root-extract. Hence, this fraction was further purified and nine compounds, including two new ursane type triterpenoids Fulgic acid A (4) and Fulgic acid B (5), were identified and characterized. Other compounds were identified as ursolic acid, euscaphic acid, corosolic acid, epicatechin, catechin, p-hydroxybenzaldehyde and gallic acid. Chemical structures were elucidated by spectroscopic methods, especially ESIHRMS and 2D NMR techniques. The new compounds showed good antioxidant activity and therefore this plant can be a source of natural antioxidants. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24060908/Two_new_stereoisomeric_antioxidant_triterpenes_from_Potentilla_fulgens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(13)00243-8 DB - PRIME DP - Unbound Medicine ER -