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Intestinal complications of cystic fibrosis.
Curr Opin Pulm Med 2013; 19(6):676-80CO

Abstract

PURPOSE OF REVIEW

The article reviews advances in gastrointestinal aspects of cystic fibrosis (CF) published in the literature over the past year, and highlights new and interesting research.

RECENT FINDINGS

Animal models can be used to understand the pathophysiology of gastrointestinal complications in CF. The CF mouse is useful for studying distal intestinal obstruction, dysmotility and dysbiosis, and the CF pig model has helped us better understand meconium ileus and pancreatic and hepatobiliary secretory problems. Studies in humans help elucidate the evolution of pancreatic insufficiency, how reflux may lead to lung disease, problems with intestinal dysmotility, mechanisms leading to pancreatitis and the increased prevalence of gastrointestinal cancer. Biomarkers are shedding light on CF-related liver disease. Rectal biopsies can help in diagnosis and in studying new drugs for CF.

SUMMARY

Gastrointestinal complications of CF are likely to be seen with increasing frequency as patients with CF lead longer lives. CF animal models and modern research techniques are providing new insights into extrapulmonary complications. CF clinicians should be familiar with diagnosis and management of common gastrointestinal complications and should build bridges with specialists so that referrals can be made when needed.

Authors+Show Affiliations

Department of Pediatrics, State University of New York at Buffalo, New York, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24060981

Citation

Borowitz, Drucy, and Daniel Gelfond. "Intestinal Complications of Cystic Fibrosis." Current Opinion in Pulmonary Medicine, vol. 19, no. 6, 2013, pp. 676-80.
Borowitz D, Gelfond D. Intestinal complications of cystic fibrosis. Curr Opin Pulm Med. 2013;19(6):676-80.
Borowitz, D., & Gelfond, D. (2013). Intestinal complications of cystic fibrosis. Current Opinion in Pulmonary Medicine, 19(6), pp. 676-80. doi:10.1097/MCP.0b013e3283659ef2.
Borowitz D, Gelfond D. Intestinal Complications of Cystic Fibrosis. Curr Opin Pulm Med. 2013;19(6):676-80. PubMed PMID: 24060981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal complications of cystic fibrosis. AU - Borowitz,Drucy, AU - Gelfond,Daniel, PY - 2013/9/25/entrez PY - 2013/9/26/pubmed PY - 2014/6/4/medline SP - 676 EP - 80 JF - Current opinion in pulmonary medicine JO - Curr Opin Pulm Med VL - 19 IS - 6 N2 - PURPOSE OF REVIEW: The article reviews advances in gastrointestinal aspects of cystic fibrosis (CF) published in the literature over the past year, and highlights new and interesting research. RECENT FINDINGS: Animal models can be used to understand the pathophysiology of gastrointestinal complications in CF. The CF mouse is useful for studying distal intestinal obstruction, dysmotility and dysbiosis, and the CF pig model has helped us better understand meconium ileus and pancreatic and hepatobiliary secretory problems. Studies in humans help elucidate the evolution of pancreatic insufficiency, how reflux may lead to lung disease, problems with intestinal dysmotility, mechanisms leading to pancreatitis and the increased prevalence of gastrointestinal cancer. Biomarkers are shedding light on CF-related liver disease. Rectal biopsies can help in diagnosis and in studying new drugs for CF. SUMMARY: Gastrointestinal complications of CF are likely to be seen with increasing frequency as patients with CF lead longer lives. CF animal models and modern research techniques are providing new insights into extrapulmonary complications. CF clinicians should be familiar with diagnosis and management of common gastrointestinal complications and should build bridges with specialists so that referrals can be made when needed. SN - 1531-6971 UR - https://www.unboundmedicine.com/medline/citation/24060981/Intestinal_complications_of_cystic_fibrosis_ L2 - http://Insights.ovid.com/pubmed?pmid=24060981 DB - PRIME DP - Unbound Medicine ER -