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Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers.
Am J Hypertens 2014; 27(1):38-45AJ

Abstract

BACKGROUND

Smoking is associated with impaired vascular function. Concord grape juice (CGJ), a rich source of flavonoids, can modify cardiovascular risk factors. Endothelial function and arterial stiffness are surrogate markers of arterial health. We examined the impact of CGJ on arterial wall properties in healthy smokers.

METHODS

We studied the effect of a 2-week oral treatment with CGJ in 26 healthy smokers on 3 occasions (day 0 (baseline), day 7, and day 14) in a randomized, placebo-controlled, double-blind, crossover study. Measurements were taken before (pSm), immediately after (Sm0), and 20 minutes after (Sm20) cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness.

RESULTS

Compared with placebo, treatment with CGJ resulted in a significant improvement in pSm values of FMD (P = 0.02) and PWV (P = 0.04). At baseline, smoking decreased FMD in both the CGJ group (P < 0.001) and the placebo group (P < 0.001). Compared with placebo, CGJ treatment prevented the acute smoking-induced decrease in FMD on day 7 (P = 0.02) and day 14 (P < 0.001). Moreover, at baseline, smoking induced a significant elevation in PWV in both the CGJ group (P = 0.02) and the placebo group (P = 0.04). Treatment with CGJ prevented the smoking-induced elevation in PWV on day 7 (P = 0.003) and day 14 (P < 0.001).

CONCLUSIONS

CGJ consumption improved endothelial function and vascular elastic properties of the arterial tree in healthy smokers and attenuated acute smoking-induced impairment of arterial wall properties.

Authors+Show Affiliations

First Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24061071

Citation

Siasos, Gerasimos, et al. "Favorable Effects of Concord Grape Juice On Endothelial Function and Arterial Stiffness in Healthy Smokers." American Journal of Hypertension, vol. 27, no. 1, 2014, pp. 38-45.
Siasos G, Tousoulis D, Kokkou E, et al. Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. Am J Hypertens. 2014;27(1):38-45.
Siasos, G., Tousoulis, D., Kokkou, E., Oikonomou, E., Kollia, M. E., Verveniotis, A., ... Stefanadis, C. (2014). Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. American Journal of Hypertension, 27(1), pp. 38-45. doi:10.1093/ajh/hpt176.
Siasos G, et al. Favorable Effects of Concord Grape Juice On Endothelial Function and Arterial Stiffness in Healthy Smokers. Am J Hypertens. 2014;27(1):38-45. PubMed PMID: 24061071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. AU - Siasos,Gerasimos, AU - Tousoulis,Dimitris, AU - Kokkou,Eleni, AU - Oikonomou,Evangelos, AU - Kollia,Maria-Eleni, AU - Verveniotis,Aleksis, AU - Gouliopoulos,Nikolaos, AU - Zisimos,Konstantinos, AU - Plastiras,Aris, AU - Maniatis,Konstantinos, AU - Stefanadis,Christodoulos, Y1 - 2013/09/23/ PY - 2013/9/25/entrez PY - 2013/9/26/pubmed PY - 2014/7/30/medline KW - arterial stiffness KW - blood pressure KW - cigarette smoking KW - endothelial dysfunction KW - flavonoids KW - grape juice KW - hypertension. SP - 38 EP - 45 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 27 IS - 1 N2 - BACKGROUND: Smoking is associated with impaired vascular function. Concord grape juice (CGJ), a rich source of flavonoids, can modify cardiovascular risk factors. Endothelial function and arterial stiffness are surrogate markers of arterial health. We examined the impact of CGJ on arterial wall properties in healthy smokers. METHODS: We studied the effect of a 2-week oral treatment with CGJ in 26 healthy smokers on 3 occasions (day 0 (baseline), day 7, and day 14) in a randomized, placebo-controlled, double-blind, crossover study. Measurements were taken before (pSm), immediately after (Sm0), and 20 minutes after (Sm20) cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness. RESULTS: Compared with placebo, treatment with CGJ resulted in a significant improvement in pSm values of FMD (P = 0.02) and PWV (P = 0.04). At baseline, smoking decreased FMD in both the CGJ group (P < 0.001) and the placebo group (P < 0.001). Compared with placebo, CGJ treatment prevented the acute smoking-induced decrease in FMD on day 7 (P = 0.02) and day 14 (P < 0.001). Moreover, at baseline, smoking induced a significant elevation in PWV in both the CGJ group (P = 0.02) and the placebo group (P = 0.04). Treatment with CGJ prevented the smoking-induced elevation in PWV on day 7 (P = 0.003) and day 14 (P < 0.001). CONCLUSIONS: CGJ consumption improved endothelial function and vascular elastic properties of the arterial tree in healthy smokers and attenuated acute smoking-induced impairment of arterial wall properties. SN - 1941-7225 UR - https://www.unboundmedicine.com/medline/citation/24061071/Favorable_effects_of_concord_grape_juice_on_endothelial_function_and_arterial_stiffness_in_healthy_smokers_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1093/ajh/hpt176 DB - PRIME DP - Unbound Medicine ER -