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Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil.
Reproduction. 2013 Dec; 146(6):603-14.R

Abstract

The objectives of this study were to determine the differential incorporation of various omega-3 (n-3) fatty acids (FAs) supplemented to dairy cows into ovarian compartments and assess the effects on IVF. Forty-two 256-day pregnant cows were supplemented with encapsulated fats, in treatments designated as i) SFA - saturated fat at 240 and 560 g/day per cow, prepartum and post partum (PP) respectively; ii) FLX - flaxseed oil at 300 and 700 g/day per cow prepartum and PP respectively; and iii) FO - fish oil at 300 and 700 g/day per cow prepartum and PP respectively. Commencing at 60 days in lactation, ovum pickup (OPU) was performed twice weekly (20 sessions; five cows per group) and in vitro maturation and IVF were conducted. The proportion of α-linolenic acid (ALA) was greater in follicular fluid (FF), granulosa cells, and cumulus-oocyte complexes (COCs) of FLX cows than in other groups (P<0.001). The proportion of docosahexaenoic acid (DHA) was 6.7 times as great in FF of FO as in other groups (P<0.001); docosapentaenoic acid n-3 and DHA were detected in COCs of FO but not in others. The follicle number during OPU was higher in FLX and FO than in SFA (P<0.05), and the oocyte cleavage rate was higher in FLX and FO than in SFA (P<0.01). Also, the percentage of oocytes that developed to blastocysts tended to be higher in both n-3 groups than in SFA (P<0.1). In conclusion, both dietary n-3 FAs similarly improved folliculogenesis and IVF performance; therefore, ALA-rich botanical n-3 seems to be a satisfactory approach to improve oocyte quality.

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Publisher Full Text

Authors+Show Affiliations

Moallem U
Department of Ruminant Science, Institute of Animal Sciences, the Volcani Center, PO Box 6, Bet-Dagan 50250, Israel.
Shafran A
No affiliation info available
Zachut M
No affiliation info available
Dekel I
No affiliation info available
Portnick Y
No affiliation info available
Arieli A
No affiliation info available

MeSH

AnimalsCattleDairyingDietary FatsDocosahexaenoic AcidsEicosapentaenoic AcidFemaleFertilization in VitroFish OilsLinseed OilOvarian FolliclePregnancyTreatment Outcomealpha-Linolenic Acid

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24062566

Citation

Moallem, U, et al. "Dietary Α-linolenic Acid From Flaxseed Oil Improved Folliculogenesis and IVF Performance in Dairy Cows, Similar to Eicosapentaenoic and Docosahexaenoic Acids From Fish Oil." Reproduction (Cambridge, England), vol. 146, no. 6, 2013, pp. 603-14.
Moallem U, Shafran A, Zachut M, et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. Reproduction. 2013;146(6):603-14.
Moallem, U., Shafran, A., Zachut, M., Dekel, I., Portnick, Y., & Arieli, A. (2013). Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. Reproduction (Cambridge, England), 146(6), 603-14. https://doi.org/10.1530/REP-13-0244
Moallem U, et al. Dietary Α-linolenic Acid From Flaxseed Oil Improved Folliculogenesis and IVF Performance in Dairy Cows, Similar to Eicosapentaenoic and Docosahexaenoic Acids From Fish Oil. Reproduction. 2013;146(6):603-14. PubMed PMID: 24062566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. AU - Moallem,U, AU - Shafran,A, AU - Zachut,M, AU - Dekel,I, AU - Portnick,Y, AU - Arieli,A, Y1 - 2013/10/26/ PY - 2013/9/25/entrez PY - 2013/9/26/pubmed PY - 2014/7/16/medline SP - 603 EP - 14 JF - Reproduction (Cambridge, England) JO - Reproduction VL - 146 IS - 6 N2 - The objectives of this study were to determine the differential incorporation of various omega-3 (n-3) fatty acids (FAs) supplemented to dairy cows into ovarian compartments and assess the effects on IVF. Forty-two 256-day pregnant cows were supplemented with encapsulated fats, in treatments designated as i) SFA - saturated fat at 240 and 560 g/day per cow, prepartum and post partum (PP) respectively; ii) FLX - flaxseed oil at 300 and 700 g/day per cow prepartum and PP respectively; and iii) FO - fish oil at 300 and 700 g/day per cow prepartum and PP respectively. Commencing at 60 days in lactation, ovum pickup (OPU) was performed twice weekly (20 sessions; five cows per group) and in vitro maturation and IVF were conducted. The proportion of α-linolenic acid (ALA) was greater in follicular fluid (FF), granulosa cells, and cumulus-oocyte complexes (COCs) of FLX cows than in other groups (P<0.001). The proportion of docosahexaenoic acid (DHA) was 6.7 times as great in FF of FO as in other groups (P<0.001); docosapentaenoic acid n-3 and DHA were detected in COCs of FO but not in others. The follicle number during OPU was higher in FLX and FO than in SFA (P<0.05), and the oocyte cleavage rate was higher in FLX and FO than in SFA (P<0.01). Also, the percentage of oocytes that developed to blastocysts tended to be higher in both n-3 groups than in SFA (P<0.1). In conclusion, both dietary n-3 FAs similarly improved folliculogenesis and IVF performance; therefore, ALA-rich botanical n-3 seems to be a satisfactory approach to improve oocyte quality. SN - 1741-7899 UR - https://www.unboundmedicine.com/medline/citation/24062566/Dietary_α_linolenic_acid_from_flaxseed_oil_improved_folliculogenesis_and_IVF_performance_in_dairy_cows_similar_to_eicosapentaenoic_and_docosahexaenoic_acids_from_fish_oil_ L2 - https://rep.bioscientifica.com/doi/10.1530/REP-13-0244 DB - PRIME DP - Unbound Medicine ER -
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