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Relationship of estimated glomerular filtration rate with lower urinary tract symptoms/benign prostatic hyperplasia measures in middle-aged men with moderate to severe lower urinary tract symptoms.
Urology. 2013 Dec; 82(6):1381-5.U

Abstract

OBJECTIVE

To evaluate the relationship of the glomerular filtration rate (GFR) and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia measures in middle-aged men.

METHODS

A total of 1400 male police officers with moderate and severe LUTS (international prostate symptoms score [IPSS] >7) and aged 40-59 years who had participated in a health examination were included. LUTS/benign prostatic hyperplasia was measured with IPSS, transrectal ultrasonography, uroflowmetry, and postvoid residual urine volume. We estimated the GFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Spearman correlation tests and multiple linear regression tests were used to evaluate the relationship.

RESULTS

The median age was 50.0 years, and the median GFR was 85.3 mL/min/1.73 m(2). The GFR showed a significant positive correlation with the maximal flow rate (Qmax; r = .112; P <.001). However, there was no significant correlation of GFR with IPSS (r = -.018; P = .493), total prostate volume (r = -.032; P = .237), and postvoid residual (r = -.066; P = .051). After adjusting for age, body mass index (BMI), and metabolic syndrome, only Qmax showed a positive correlation with GFR (beta = .114; P = .003).

CONCLUSION

Qmax demonstrated a significant correlation with GFR in middle-aged men with moderate to severe LUTS in this study. Our data suggest that improved clinical attention is required for patients with LUTS and a low Qmax.

Authors+Show Affiliations

Department of Urology, National Police Hospital, Seoul, Republic of Korea. Electronic address: sinbnapolee@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24063940

Citation

Lee, Jun Ho, et al. "Relationship of Estimated Glomerular Filtration Rate With Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia Measures in Middle-aged Men With Moderate to Severe Lower Urinary Tract Symptoms." Urology, vol. 82, no. 6, 2013, pp. 1381-5.
Lee JH, Kwon H, Park YW, et al. Relationship of estimated glomerular filtration rate with lower urinary tract symptoms/benign prostatic hyperplasia measures in middle-aged men with moderate to severe lower urinary tract symptoms. Urology. 2013;82(6):1381-5.
Lee, J. H., Kwon, H., Park, Y. W., Cho, I. C., & Min, S. K. (2013). Relationship of estimated glomerular filtration rate with lower urinary tract symptoms/benign prostatic hyperplasia measures in middle-aged men with moderate to severe lower urinary tract symptoms. Urology, 82(6), 1381-5. https://doi.org/10.1016/j.urology.2013.07.049
Lee JH, et al. Relationship of Estimated Glomerular Filtration Rate With Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia Measures in Middle-aged Men With Moderate to Severe Lower Urinary Tract Symptoms. Urology. 2013;82(6):1381-5. PubMed PMID: 24063940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of estimated glomerular filtration rate with lower urinary tract symptoms/benign prostatic hyperplasia measures in middle-aged men with moderate to severe lower urinary tract symptoms. AU - Lee,Jun Ho, AU - Kwon,Hanna, AU - Park,Yeon Won, AU - Cho,In-Chang, AU - Min,Seung Ki, Y1 - 2013/09/21/ PY - 2013/06/26/received PY - 2013/07/26/revised PY - 2013/07/31/accepted PY - 2013/9/26/entrez PY - 2013/9/26/pubmed PY - 2014/3/14/medline SP - 1381 EP - 5 JF - Urology JO - Urology VL - 82 IS - 6 N2 - OBJECTIVE: To evaluate the relationship of the glomerular filtration rate (GFR) and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia measures in middle-aged men. METHODS: A total of 1400 male police officers with moderate and severe LUTS (international prostate symptoms score [IPSS] >7) and aged 40-59 years who had participated in a health examination were included. LUTS/benign prostatic hyperplasia was measured with IPSS, transrectal ultrasonography, uroflowmetry, and postvoid residual urine volume. We estimated the GFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Spearman correlation tests and multiple linear regression tests were used to evaluate the relationship. RESULTS: The median age was 50.0 years, and the median GFR was 85.3 mL/min/1.73 m(2). The GFR showed a significant positive correlation with the maximal flow rate (Qmax; r = .112; P <.001). However, there was no significant correlation of GFR with IPSS (r = -.018; P = .493), total prostate volume (r = -.032; P = .237), and postvoid residual (r = -.066; P = .051). After adjusting for age, body mass index (BMI), and metabolic syndrome, only Qmax showed a positive correlation with GFR (beta = .114; P = .003). CONCLUSION: Qmax demonstrated a significant correlation with GFR in middle-aged men with moderate to severe LUTS in this study. Our data suggest that improved clinical attention is required for patients with LUTS and a low Qmax. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/24063940/Relationship_of_estimated_glomerular_filtration_rate_with_lower_urinary_tract_symptoms/benign_prostatic_hyperplasia_measures_in_middle_aged_men_with_moderate_to_severe_lower_urinary_tract_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(13)01041-8 DB - PRIME DP - Unbound Medicine ER -