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Hormone receptor and HER2 status in patients with breast cancer by races in southeastern Turkey.
J BUON. 2013 Jul-Sep; 18(3):619-22.JB

Abstract

PURPOSE

Hormone receptor (HR) status is a prognostic factor in women with breast cancer and differs among different ethnic groups. HR status among Turkish, Kurdish and Arabic women with breast cancer living in Turkey is unknown and in this study we investigated the relationship between HR and HER2 status and race.

METHODS

FA total of 648 women with breast cancer (Turkish 438, Kurdish 174, Arabic 35 and Armenian 1) living in southeastern Turkey and referred to the Department of Radiation Oncology between July 2006-July 2012 were included in the study. Patients were categorized into 4 groups according to their HR status. Estrogen receptor (ER) and progesterone receptor (PR) positive (ER+/PR+), ER positive and PR negative (ER+/PR-), ER negative and PR positive (ER-/PR+) and ER and PR negative (ER-/PR-). Human epidermal growth factor receptor 2 (HER2) status was recorded immunohistochemically (IHC) as negative (0 and 1+), and positive (3+). Statistical analysis included ER, PR, HER2, triple subtypes (combination of ER, PR and HER2), and race.

RESULTS

The median age at diagnosis was 48 years (range 20-83). ER+, PR+ and HER2+ patients were 453 (70%), 470 (72.6%) and 206 (32.1%), respectively. ER+/PR+ rates among Turkish and Arabic patients were similar, but were higher than Kurdish patients (p<0.002). Triple-negative (ER-/PR-/HER2-) rates among Kurdish and Arabic patients were similar, but were higher than Turkish patients (p=0.04).

CONCLUSION

Turkish, Kurdish and Arabic women with breast cancer in southeastern Turkey differed by HR status. Compared to Turkish and Arabic patients, Kurdish patients had more unfavorable prognostic factors.

Authors+Show Affiliations

Gaziantep University Faculty of Medicine, Department of Radiation Oncology, Gaziantep, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24065473

Citation

Kuzhan, A, et al. "Hormone Receptor and HER2 Status in Patients With Breast Cancer By Races in Southeastern Turkey." Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, vol. 18, no. 3, 2013, pp. 619-22.
Kuzhan A, Adli M, Eryigit Alkis H, et al. Hormone receptor and HER2 status in patients with breast cancer by races in southeastern Turkey. J BUON. 2013;18(3):619-22.
Kuzhan, A., Adli, M., Eryigit Alkis, H., & Caglayan, D. (2013). Hormone receptor and HER2 status in patients with breast cancer by races in southeastern Turkey. Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, 18(3), 619-22.
Kuzhan A, et al. Hormone Receptor and HER2 Status in Patients With Breast Cancer By Races in Southeastern Turkey. J BUON. 2013 Jul-Sep;18(3):619-22. PubMed PMID: 24065473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone receptor and HER2 status in patients with breast cancer by races in southeastern Turkey. AU - Kuzhan,A, AU - Adli,M, AU - Eryigit Alkis,H, AU - Caglayan,D, PY - 2013/9/26/entrez PY - 2013/9/26/pubmed PY - 2014/2/12/medline SP - 619 EP - 22 JF - Journal of B.U.ON. : official journal of the Balkan Union of Oncology JO - J BUON VL - 18 IS - 3 N2 - PURPOSE: Hormone receptor (HR) status is a prognostic factor in women with breast cancer and differs among different ethnic groups. HR status among Turkish, Kurdish and Arabic women with breast cancer living in Turkey is unknown and in this study we investigated the relationship between HR and HER2 status and race. METHODS: FA total of 648 women with breast cancer (Turkish 438, Kurdish 174, Arabic 35 and Armenian 1) living in southeastern Turkey and referred to the Department of Radiation Oncology between July 2006-July 2012 were included in the study. Patients were categorized into 4 groups according to their HR status. Estrogen receptor (ER) and progesterone receptor (PR) positive (ER+/PR+), ER positive and PR negative (ER+/PR-), ER negative and PR positive (ER-/PR+) and ER and PR negative (ER-/PR-). Human epidermal growth factor receptor 2 (HER2) status was recorded immunohistochemically (IHC) as negative (0 and 1+), and positive (3+). Statistical analysis included ER, PR, HER2, triple subtypes (combination of ER, PR and HER2), and race. RESULTS: The median age at diagnosis was 48 years (range 20-83). ER+, PR+ and HER2+ patients were 453 (70%), 470 (72.6%) and 206 (32.1%), respectively. ER+/PR+ rates among Turkish and Arabic patients were similar, but were higher than Kurdish patients (p<0.002). Triple-negative (ER-/PR-/HER2-) rates among Kurdish and Arabic patients were similar, but were higher than Turkish patients (p=0.04). CONCLUSION: Turkish, Kurdish and Arabic women with breast cancer in southeastern Turkey differed by HR status. Compared to Turkish and Arabic patients, Kurdish patients had more unfavorable prognostic factors. SN - 1107-0625 UR - https://www.unboundmedicine.com/medline/citation/24065473/Hormone_receptor_and_HER2_status_in_patients_with_breast_cancer_by_races_in_southeastern_Turkey_ L2 - https://www.jbuon.com/archive/18-3-619.pdf DB - PRIME DP - Unbound Medicine ER -