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Disparate survival and risk of secondary non-Hodgkin lymphoma in histologic subtypes of Hodgkin lymphoma: a population-based study.
Leuk Lymphoma 2014; 55(7):1570-7LL

Abstract

We compared survival outcomes and rates of secondary non-Hodgkin lymphoma (NHL) in 28 323 patients with nodular lymphocyte predominant (NLPHL) and classical Hodgkin lymphoma (HL) from the Surveillance, Epidemiology and End Results database, diagnosed between 1995 and 2010. In a multivariate analysis NLPHL demonstrated a significantly better relative survival (5-year risk of lymphoma-related death 5.7%, hazard ratio [HR] 0.46, p < 0.0001) than the reference nodular sclerosis (NSHL) subtype (5-year risk 12.7%). Lymphocyte-rich classical HL had outcomes comparable to NSHL (5-year risk 14.3%, HR 0.84, p = 0.11). Exceptionally poor outcomes were observed in lymphocyte depleted HL (5-year risk 48.8%, HR 2.26, p < 0.0001). The risk of secondary NHL was increased in NLPHL (HR 2.81, p < 0.001) and lymphocyte-rich classical HL (HR 2.27, p = 0.002), but not in other subtypes compared with NSHL. In conclusion, the histologic classification retains a significant prognostic value in HL and the disparities between the subtypes warrant customized treatment and surveillance strategies.

Authors+Show Affiliations

Alpert Medical School of Brown University , Providence, RI , USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24067135

Citation

Ali, Shihab, and Adam J. Olszewski. "Disparate Survival and Risk of Secondary non-Hodgkin Lymphoma in Histologic Subtypes of Hodgkin Lymphoma: a Population-based Study." Leukemia & Lymphoma, vol. 55, no. 7, 2014, pp. 1570-7.
Ali S, Olszewski AJ. Disparate survival and risk of secondary non-Hodgkin lymphoma in histologic subtypes of Hodgkin lymphoma: a population-based study. Leuk Lymphoma. 2014;55(7):1570-7.
Ali, S., & Olszewski, A. J. (2014). Disparate survival and risk of secondary non-Hodgkin lymphoma in histologic subtypes of Hodgkin lymphoma: a population-based study. Leukemia & Lymphoma, 55(7), pp. 1570-7. doi:10.3109/10428194.2013.847938.
Ali S, Olszewski AJ. Disparate Survival and Risk of Secondary non-Hodgkin Lymphoma in Histologic Subtypes of Hodgkin Lymphoma: a Population-based Study. Leuk Lymphoma. 2014;55(7):1570-7. PubMed PMID: 24067135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disparate survival and risk of secondary non-Hodgkin lymphoma in histologic subtypes of Hodgkin lymphoma: a population-based study. AU - Ali,Shihab, AU - Olszewski,Adam J, Y1 - 2013/11/12/ PY - 2013/9/27/entrez PY - 2013/9/27/pubmed PY - 2016/3/24/medline KW - Hodgkin lymphoma KW - SEER KW - epidemiology KW - secondary malignancies SP - 1570 EP - 7 JF - Leukemia & lymphoma JO - Leuk. Lymphoma VL - 55 IS - 7 N2 - We compared survival outcomes and rates of secondary non-Hodgkin lymphoma (NHL) in 28 323 patients with nodular lymphocyte predominant (NLPHL) and classical Hodgkin lymphoma (HL) from the Surveillance, Epidemiology and End Results database, diagnosed between 1995 and 2010. In a multivariate analysis NLPHL demonstrated a significantly better relative survival (5-year risk of lymphoma-related death 5.7%, hazard ratio [HR] 0.46, p < 0.0001) than the reference nodular sclerosis (NSHL) subtype (5-year risk 12.7%). Lymphocyte-rich classical HL had outcomes comparable to NSHL (5-year risk 14.3%, HR 0.84, p = 0.11). Exceptionally poor outcomes were observed in lymphocyte depleted HL (5-year risk 48.8%, HR 2.26, p < 0.0001). The risk of secondary NHL was increased in NLPHL (HR 2.81, p < 0.001) and lymphocyte-rich classical HL (HR 2.27, p = 0.002), but not in other subtypes compared with NSHL. In conclusion, the histologic classification retains a significant prognostic value in HL and the disparities between the subtypes warrant customized treatment and surveillance strategies. SN - 1029-2403 UR - https://www.unboundmedicine.com/medline/citation/24067135/Disparate_survival_and_risk_of_secondary_non_Hodgkin_lymphoma_in_histologic_subtypes_of_Hodgkin_lymphoma:_a_population_based_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/10428194.2013.847938 DB - PRIME DP - Unbound Medicine ER -