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Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis.
Gen Physiol Biophys 2013; 32(4):459-66GP

Abstract

Recent findings suggest that polymorphisms in vitamin D pathway genes are candidates for association with multiple sclerosis susceptibility. It has been now well demonstrated that vitamin D has immunomodulatory functions that may be favorable for reduction of multiple sclerosis risk. Current research has been focused on identification of new variants of genes involved in vitamin D pathway, namely in vitamin D receptor and enzymes of vitamin D metabolism. These variants have been intensively studied as possible genetic predictors of both vitamin D levels and the risk of multiple sclerosis. Considering the findings available up-to-date, we may recognize two groups of genetic variants. The first group of genes was found to predict vitamin D levels but not the risk of multiple sclerosis. The second group of genetic variants is represented by promising genes predicting vitamin D levels as well as the risk of multiple sclerosis. A strong association with increased risk of the disease has been observed for a rare variant in the CYP27B1 gene encoding a vitamin D-activating enzyme. Observed interaction between genetic and epidemiological findings brings the rationale for supplementation trials of vitamin D. Although promising effects of vitamin D supplementation have emerged, the results obtained so far are inconclusive and the real therapeutic significance of vitamin D supplementation remains to be elucidated.

Authors+Show Affiliations

1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic. lucia.krizova@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24067280

Citation

Krizova, Lucia, et al. "Genetic Aspects of Vitamin D Receptor and Metabolism in Relation to the Risk of Multiple Sclerosis." General Physiology and Biophysics, vol. 32, no. 4, 2013, pp. 459-66.
Krizova L, Kollar B, Jezova D, et al. Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. Gen Physiol Biophys. 2013;32(4):459-66.
Krizova, L., Kollar, B., Jezova, D., & Turcani, P. (2013). Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. General Physiology and Biophysics, 32(4), pp. 459-66. doi:10.4149/gpb_2013067.
Krizova L, et al. Genetic Aspects of Vitamin D Receptor and Metabolism in Relation to the Risk of Multiple Sclerosis. Gen Physiol Biophys. 2013;32(4):459-66. PubMed PMID: 24067280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. AU - Krizova,Lucia, AU - Kollar,Branislav, AU - Jezova,Daniela, AU - Turcani,Peter, Y1 - 2013/09/26/ PY - 2013/02/22/received PY - 2013/08/09/accepted PY - 2013/9/27/entrez PY - 2013/9/27/pubmed PY - 2014/3/29/medline SP - 459 EP - 66 JF - General physiology and biophysics JO - Gen. Physiol. Biophys. VL - 32 IS - 4 N2 - Recent findings suggest that polymorphisms in vitamin D pathway genes are candidates for association with multiple sclerosis susceptibility. It has been now well demonstrated that vitamin D has immunomodulatory functions that may be favorable for reduction of multiple sclerosis risk. Current research has been focused on identification of new variants of genes involved in vitamin D pathway, namely in vitamin D receptor and enzymes of vitamin D metabolism. These variants have been intensively studied as possible genetic predictors of both vitamin D levels and the risk of multiple sclerosis. Considering the findings available up-to-date, we may recognize two groups of genetic variants. The first group of genes was found to predict vitamin D levels but not the risk of multiple sclerosis. The second group of genetic variants is represented by promising genes predicting vitamin D levels as well as the risk of multiple sclerosis. A strong association with increased risk of the disease has been observed for a rare variant in the CYP27B1 gene encoding a vitamin D-activating enzyme. Observed interaction between genetic and epidemiological findings brings the rationale for supplementation trials of vitamin D. Although promising effects of vitamin D supplementation have emerged, the results obtained so far are inconclusive and the real therapeutic significance of vitamin D supplementation remains to be elucidated. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/24067280/Genetic_aspects_of_vitamin_D_receptor_and_metabolism_in_relation_to_the_risk_of_multiple_sclerosis_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=GPB&file=2013_04_459.pdf DB - PRIME DP - Unbound Medicine ER -