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Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin.
J Cutan Med Surg. 2013 Sep-Oct; 17(5):347-50.JC

Abstract

BACKGROUND

Necrobiotic xanthogranuloma (NXG) is a rare chronic disorder characterized by firm yellow to red-orange nodules and plaques affecting the face, abdomen, and extremities with the potential for systemic involvement. NXG has a close association with monoclonal gammopathies, and there is a predilection for the development of multiple myeloma. Treatment options are varied due to inconsistent results seen with the use of corticosteroids, immunomodulators, chemotherapeutic agents, and antibiotics.

OBJECTIVE

We describe a patient with smoldering multiple myeloma associated with progressive NXG successfully treated with high-dose intravenous immunoglobulin (IVIG).

CONCLUSION

Our case adds to the single previous report of two cases of NXG with significant improvement from treatment with IVIG and confirms the efficacy of this treatment modality.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24067856

Citation

Rubinstein, Arye, et al. "Successful Treatment of Necrobiotic Xanthogranuloma With Intravenous Immunoglobulin." Journal of Cutaneous Medicine and Surgery, vol. 17, no. 5, 2013, pp. 347-50.
Rubinstein A, Wolf DJ, Granstein RD. Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin. J Cutan Med Surg. 2013;17(5):347-50.
Rubinstein, A., Wolf, D. J., & Granstein, R. D. (2013). Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin. Journal of Cutaneous Medicine and Surgery, 17(5), 347-50.
Rubinstein A, Wolf DJ, Granstein RD. Successful Treatment of Necrobiotic Xanthogranuloma With Intravenous Immunoglobulin. J Cutan Med Surg. 2013;17(5):347-50. PubMed PMID: 24067856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin. AU - Rubinstein,Arye, AU - Wolf,David J, AU - Granstein,Richard D, PY - 2013/9/27/entrez PY - 2013/9/27/pubmed PY - 2014/1/29/medline SP - 347 EP - 50 JF - Journal of cutaneous medicine and surgery JO - J Cutan Med Surg VL - 17 IS - 5 N2 - BACKGROUND: Necrobiotic xanthogranuloma (NXG) is a rare chronic disorder characterized by firm yellow to red-orange nodules and plaques affecting the face, abdomen, and extremities with the potential for systemic involvement. NXG has a close association with monoclonal gammopathies, and there is a predilection for the development of multiple myeloma. Treatment options are varied due to inconsistent results seen with the use of corticosteroids, immunomodulators, chemotherapeutic agents, and antibiotics. OBJECTIVE: We describe a patient with smoldering multiple myeloma associated with progressive NXG successfully treated with high-dose intravenous immunoglobulin (IVIG). CONCLUSION: Our case adds to the single previous report of two cases of NXG with significant improvement from treatment with IVIG and confirms the efficacy of this treatment modality. SN - 1203-4754 UR - https://www.unboundmedicine.com/medline/citation/24067856/Successful_treatment_of_necrobiotic_xanthogranuloma_with_intravenous_immunoglobulin_ L2 - http://journals.sagepub.com/doi/full/10.2310/7750.2013.13012?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -