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Seroprevalence and demographic determinants of human T-lymphotropic virus type 1 and 2 infections among first-time blood donors--United States, 2000-2009.
J Infect Dis. 2014 Feb 15; 209(4):523-31.JI

Abstract

BACKGROUND

Human T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 are prevalent at low levels among US blood donors, but recent data on their prevalence is lacking. METHODS. Data on all first-time blood donors in a large network of US blood centers were examined during 2000-2009. HTLV-1 and HTLV-2 antibodies were measured by enzyme immunoassay (EIA) with confirmation by immunofluorescence or recombinant immunoblot. Prevalence rates were calculated, and odds ratios were assessed using multivariable logistic regression.

RESULTS

Among 2 047 740 first-time donors, 104 were seropositive for HTLV-1 (prevalence, 5.1 cases/per 100 000; 95% confidence interval [CI], 4.1-6.1), and 300 were seropositive for HTLV-2 (prevalence, 14.7 cases/per 100 000; 95% CI, 13.0-16.3). The prevalence was lower than reported in the 1990s but stable from 2000 to 2009. HTLV-1 seropositivity was associated with female sex, older age, and black and Asian race/ethnicity. HTLV-2 seropositivity was associated with female sex, older age, nonwhite race/ethnicity, lower educational level, and residence in the western and southwestern United States.

CONCLUSIONS

The HTLV-1 and HTLV-2 prevalences among US blood donors has declined since the early 1990s. A higher prevalence of HTLV-2 in the west and southwest may be attributed to endemic foci among Amerindians.

Authors+Show Affiliations

Department of Biostatistics, Columbia University, New York, New York.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24068702

Citation

Chang, Yun Brenda, et al. "Seroprevalence and Demographic Determinants of Human T-lymphotropic Virus Type 1 and 2 Infections Among First-time Blood donors--United States, 2000-2009." The Journal of Infectious Diseases, vol. 209, no. 4, 2014, pp. 523-31.
Chang YB, Kaidarova Z, Hindes D, et al. Seroprevalence and demographic determinants of human T-lymphotropic virus type 1 and 2 infections among first-time blood donors--United States, 2000-2009. J Infect Dis. 2014;209(4):523-31.
Chang, Y. B., Kaidarova, Z., Hindes, D., Bravo, M., Kiely, N., Kamel, H., Dubay, D., Hoose, B., & Murphy, E. L. (2014). Seroprevalence and demographic determinants of human T-lymphotropic virus type 1 and 2 infections among first-time blood donors--United States, 2000-2009. The Journal of Infectious Diseases, 209(4), 523-31. https://doi.org/10.1093/infdis/jit497
Chang YB, et al. Seroprevalence and Demographic Determinants of Human T-lymphotropic Virus Type 1 and 2 Infections Among First-time Blood donors--United States, 2000-2009. J Infect Dis. 2014 Feb 15;209(4):523-31. PubMed PMID: 24068702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence and demographic determinants of human T-lymphotropic virus type 1 and 2 infections among first-time blood donors--United States, 2000-2009. AU - Chang,Yun Brenda, AU - Kaidarova,Zhanna, AU - Hindes,Daniel, AU - Bravo,Marjorie, AU - Kiely,Nancy, AU - Kamel,Hany, AU - Dubay,Denise, AU - Hoose,Barbara, AU - Murphy,Edward L, Y1 - 2013/09/24/ PY - 2013/9/27/entrez PY - 2013/9/27/pubmed PY - 2014/4/15/medline KW - HTLV-1 KW - HTLV-2 KW - Human T-lymphotropic virus KW - United States KW - blood donors KW - demographic determinants KW - prevalence SP - 523 EP - 31 JF - The Journal of infectious diseases JO - J Infect Dis VL - 209 IS - 4 N2 - BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 are prevalent at low levels among US blood donors, but recent data on their prevalence is lacking. METHODS. Data on all first-time blood donors in a large network of US blood centers were examined during 2000-2009. HTLV-1 and HTLV-2 antibodies were measured by enzyme immunoassay (EIA) with confirmation by immunofluorescence or recombinant immunoblot. Prevalence rates were calculated, and odds ratios were assessed using multivariable logistic regression. RESULTS: Among 2 047 740 first-time donors, 104 were seropositive for HTLV-1 (prevalence, 5.1 cases/per 100 000; 95% confidence interval [CI], 4.1-6.1), and 300 were seropositive for HTLV-2 (prevalence, 14.7 cases/per 100 000; 95% CI, 13.0-16.3). The prevalence was lower than reported in the 1990s but stable from 2000 to 2009. HTLV-1 seropositivity was associated with female sex, older age, and black and Asian race/ethnicity. HTLV-2 seropositivity was associated with female sex, older age, nonwhite race/ethnicity, lower educational level, and residence in the western and southwestern United States. CONCLUSIONS: The HTLV-1 and HTLV-2 prevalences among US blood donors has declined since the early 1990s. A higher prevalence of HTLV-2 in the west and southwest may be attributed to endemic foci among Amerindians. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/24068702/Seroprevalence_and_demographic_determinants_of_human_T_lymphotropic_virus_type_1_and_2_infections_among_first_time_blood_donors__United_States_2000_2009_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jit497 DB - PRIME DP - Unbound Medicine ER -