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[Acute encephalitis anti-ionotropic glutamate receptor activated N-methyl-D-aspartate (NMDAR): analysis of eleven pediatric cases in Argentina (Benito Yelín Award)].
Medicina (B Aires). 2013; 73 Suppl 1:1-9.M

Abstract

Encephalitis are an inflammatory processes of various origin, among which include autoimmune origin. The identification of antibodies against the N-methyl-D- aspartate, allowed clinical immunological characterization of an entity susceptible to immunomodulatory therapy. Originally described in young women associated with ovarian teratoma, is now a recognized entity in children even in the absence of detectable tumors. The aim of the study was conducted through review of medical records, was to describe the clinical, developmental and findings in further studies of eleven children with confirmed diagnosis of this entity through identification of specific antibodies. All debuted with psychiatric symptoms in nine associating seizures, and two extrapyramidal movements. In the evolution of language all had commitment nine severe autonomic symptoms, one with hypoventilation and requirements of ARM. Brain MRI was abnormal in three. Eight had voltage EEG asymmetry and / or amplitude, three of them had spikes. Six had CSF pleocytosis and three of seven positive oligoclonal bands. Five IgM serology for mycoplasma were positive. CPK increase occurred in conjunction with antisychotics in five. With immunomodulatory treatment, five had complete recovery three behavioral disorders / cognitive deficits and one severe. A patient's clinical picture resolved without treatment. In any associated tumor was detected. We conclude that in front of a child with acute encephalopathy and clinical support this entity after infectious cause were ruled out, immunomodulatory therapy should be started early, avoid the use of antipsychotic drugs and search for possible hidden tumors.

Authors+Show Affiliations

Servicio de Neurología, Hospital de Pediatría Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

24072045

Citation

Pérez, Elisa, et al. "[Acute Encephalitis Anti-ionotropic Glutamate Receptor Activated N-methyl-D-aspartate (NMDAR): Analysis of Eleven Pediatric Cases in Argentina (Benito Yelín Award)]." Medicina, vol. 73 Suppl 1, 2013, pp. 1-9.
Pérez E, Ruggieri V, Monges S, et al. [Acute encephalitis anti-ionotropic glutamate receptor activated N-methyl-D-aspartate (NMDAR): analysis of eleven pediatric cases in Argentina (Benito Yelín Award)]. Medicina (B Aires). 2013;73 Suppl 1:1-9.
Pérez, E., Ruggieri, V., Monges, S., Loos, M., Caraballo, R., Yerga, A., Rugilo, C., Vincent, A., & Arroyo, H. A. (2013). [Acute encephalitis anti-ionotropic glutamate receptor activated N-methyl-D-aspartate (NMDAR): analysis of eleven pediatric cases in Argentina (Benito Yelín Award)]. Medicina, 73 Suppl 1, 1-9.
Pérez E, et al. [Acute Encephalitis Anti-ionotropic Glutamate Receptor Activated N-methyl-D-aspartate (NMDAR): Analysis of Eleven Pediatric Cases in Argentina (Benito Yelín Award)]. Medicina (B Aires). 2013;73 Suppl 1:1-9. PubMed PMID: 24072045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute encephalitis anti-ionotropic glutamate receptor activated N-methyl-D-aspartate (NMDAR): analysis of eleven pediatric cases in Argentina (Benito Yelín Award)]. AU - Pérez,Elisa, AU - Ruggieri,Víctor, AU - Monges,Soledad, AU - Loos,Mariana, AU - Caraballo,Roberto, AU - Yerga,Andrés, AU - Rugilo,Carlos, AU - Vincent,Angela, AU - Arroyo,Hugo A, PY - 2013/9/28/entrez PY - 2013/9/28/pubmed PY - 2014/7/16/medline KW - acute encephalitis KW - anti­NMDAR encephalitis KW - immune-mediated encephalitis KW - limbic encephalitis SP - 1 EP - 9 JF - Medicina JO - Medicina (B Aires) VL - 73 Suppl 1 N2 - Encephalitis are an inflammatory processes of various origin, among which include autoimmune origin. The identification of antibodies against the N-methyl-D- aspartate, allowed clinical immunological characterization of an entity susceptible to immunomodulatory therapy. Originally described in young women associated with ovarian teratoma, is now a recognized entity in children even in the absence of detectable tumors. The aim of the study was conducted through review of medical records, was to describe the clinical, developmental and findings in further studies of eleven children with confirmed diagnosis of this entity through identification of specific antibodies. All debuted with psychiatric symptoms in nine associating seizures, and two extrapyramidal movements. In the evolution of language all had commitment nine severe autonomic symptoms, one with hypoventilation and requirements of ARM. Brain MRI was abnormal in three. Eight had voltage EEG asymmetry and / or amplitude, three of them had spikes. Six had CSF pleocytosis and three of seven positive oligoclonal bands. Five IgM serology for mycoplasma were positive. CPK increase occurred in conjunction with antisychotics in five. With immunomodulatory treatment, five had complete recovery three behavioral disorders / cognitive deficits and one severe. A patient's clinical picture resolved without treatment. In any associated tumor was detected. We conclude that in front of a child with acute encephalopathy and clinical support this entity after infectious cause were ruled out, immunomodulatory therapy should be started early, avoid the use of antipsychotic drugs and search for possible hidden tumors. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/24072045/[Acute_encephalitis_anti_ionotropic_glutamate_receptor_activated_N_methyl_D_aspartate__NMDAR_:_analysis_of_eleven_pediatric_cases_in_Argentina__Benito_Yelín_Award_]_ L2 - http://www.medicinabuenosaires.com/PMID/24072045.pdf DB - PRIME DP - Unbound Medicine ER -