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Comparison of intuitiveness, ease of use and preference among three prefilled, disposable growth hormone injection pens.
Expert Opin Drug Deliv 2013; 10(12):1603-12EO

Abstract

BACKGROUND

Growth hormone (GH) therapy is an effective treatment for growth failure in children. Adherence rates are often low, resulting in poor linear growth. Intuitive and easy-to-use injection devices may improve adherence.

OBJECTIVES

To determine injection time, ease of use, intuitiveness and subjects' preference for Norditropin FlexPro (FP) pen (Novo Nordisk A/S, Denmark) versus Genotropin GoQuick (GQ; Pfizer Inc., USA) and Norditropin NordiFlex (NF; Novo Nordisk) pens.

METHODS

Subjects aged ≥ 10 to < 18 years, with GH deficiency, Turner syndrome or short stature following small-for-gestational-age birth were randomized to intuitiveness (no instruction) or instruction groups. Time taken to perform an injection, dose accuracy and errors were recorded. Intuitiveness, ease-of-learning and overall preference were assessed using questionnaires.

RESULTS

Sixty-four subjects, randomized to intuitiveness (n = 32; mean [SD] age, 13.1 [2.1] years) and instruction (n = 32; 13.4 [2.0] years) groups, required less time to perform the injection with FP than with GQ (mean [SD], intuitiveness 39.8 s [17.0] vs. 65.6 s [42.9], p < 0.01; instruction 40.7 s [19.7] vs. 48.1 s [25.8], p < 0.05), and a similar amount of time with NF. NF and FP were more accurate than GQ (intuitiveness group only). Fewer errors were recorded with NF followed by FP and GQ. FP and NF were considered easier to learn than GQ in both groups. In the intuitiveness group, the majority of subjects (31/32) felt confident using FP without instruction. FP was the device of overall preference in both groups.

CONCLUSION

FP was the device that was most intuitive, easiest to use and the device of overall preference.

Authors+Show Affiliations

Saarland University Medical Center, Department of Pediatrics, Adolescent Medicine , Kirrberger Str. 1, Geb. 9, 66421 Homburg/Saar , Germany +49 6841 1628315 ; +49 6841 1628433 ; tilman.rohrer@uks.eu.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24073645

Citation

Rohrer, Tilman R., et al. "Comparison of Intuitiveness, Ease of Use and Preference Among Three Prefilled, Disposable Growth Hormone Injection Pens." Expert Opinion On Drug Delivery, vol. 10, no. 12, 2013, pp. 1603-12.
Rohrer TR, Winter F, Qvist M, et al. Comparison of intuitiveness, ease of use and preference among three prefilled, disposable growth hormone injection pens. Expert Opin Drug Deliv. 2013;10(12):1603-12.
Rohrer, T. R., Winter, F., Qvist, M., & Kappelgaard, A. M. (2013). Comparison of intuitiveness, ease of use and preference among three prefilled, disposable growth hormone injection pens. Expert Opinion On Drug Delivery, 10(12), pp. 1603-12. doi:10.1517/17425247.2013.829451.
Rohrer TR, et al. Comparison of Intuitiveness, Ease of Use and Preference Among Three Prefilled, Disposable Growth Hormone Injection Pens. Expert Opin Drug Deliv. 2013;10(12):1603-12. PubMed PMID: 24073645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of intuitiveness, ease of use and preference among three prefilled, disposable growth hormone injection pens. AU - Rohrer,Tilman R, AU - Winter,Franziska, AU - Qvist,Marianne, AU - Kappelgaard,Anne-Marie, Y1 - 2013/09/28/ PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/5/23/medline SP - 1603 EP - 12 JF - Expert opinion on drug delivery JO - Expert Opin Drug Deliv VL - 10 IS - 12 N2 - BACKGROUND: Growth hormone (GH) therapy is an effective treatment for growth failure in children. Adherence rates are often low, resulting in poor linear growth. Intuitive and easy-to-use injection devices may improve adherence. OBJECTIVES: To determine injection time, ease of use, intuitiveness and subjects' preference for Norditropin FlexPro (FP) pen (Novo Nordisk A/S, Denmark) versus Genotropin GoQuick (GQ; Pfizer Inc., USA) and Norditropin NordiFlex (NF; Novo Nordisk) pens. METHODS: Subjects aged ≥ 10 to < 18 years, with GH deficiency, Turner syndrome or short stature following small-for-gestational-age birth were randomized to intuitiveness (no instruction) or instruction groups. Time taken to perform an injection, dose accuracy and errors were recorded. Intuitiveness, ease-of-learning and overall preference were assessed using questionnaires. RESULTS: Sixty-four subjects, randomized to intuitiveness (n = 32; mean [SD] age, 13.1 [2.1] years) and instruction (n = 32; 13.4 [2.0] years) groups, required less time to perform the injection with FP than with GQ (mean [SD], intuitiveness 39.8 s [17.0] vs. 65.6 s [42.9], p < 0.01; instruction 40.7 s [19.7] vs. 48.1 s [25.8], p < 0.05), and a similar amount of time with NF. NF and FP were more accurate than GQ (intuitiveness group only). Fewer errors were recorded with NF followed by FP and GQ. FP and NF were considered easier to learn than GQ in both groups. In the intuitiveness group, the majority of subjects (31/32) felt confident using FP without instruction. FP was the device of overall preference in both groups. CONCLUSION: FP was the device that was most intuitive, easiest to use and the device of overall preference. SN - 1744-7593 UR - https://www.unboundmedicine.com/medline/citation/24073645/Comparison_of_intuitiveness_ease_of_use_and_preference_among_three_prefilled_disposable_growth_hormone_injection_pens_ L2 - http://www.tandfonline.com/doi/full/10.1517/17425247.2013.829451 DB - PRIME DP - Unbound Medicine ER -