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Chemical composition and bioactivity of essential oils of Hypericum helianthemoides, Hypericum perforatum and Hypericum scabrum.
Pharm Biol. 2014 Feb; 52(2):175-81.PB

Abstract

CONTEXT

A number Hypericum species are well known for their therapeutic efficacy and use in traditional medicine. The various species of Hypericum have been traditionally used for the treatment of wounds, eczema, burns, trauma, rheumatism, neuralgia, gastroenteritis, ulcers, hysteria, bedwetting and depression.

OBJECTIVE

This study evaluated the in vitro antioxidant, antibacterial and phytochemical properties of essential oils of Hypericum helianthemoides (Spach) Boiss., Hypericum perforatum L. and Hypericum scabrum L. (Hypericaceae) collected from alpine region of Southwest Iran.

MATERIALS AND METHODS

The essential oils obtained from dried flowering aerial parts of three Hypericum species were analyzed by gas chromatography and gas chromatography/mass spectrometry to determine chemical compositions. The antibacterial activity of essential oils within concentration ranges from 16 to 500 µg/mL was individually evaluated against Bacillus cereus, Listeria monocytogenes. Proteus vulgaris and Salmonella typhimurium. The 1,1-diphenyl-2-picrilhydrazyl (DPPH) radical scavenging activity of essential oils was determined using DPPH assay.

RESULTS

Essential oil yield of H. helianthemoides. H. scabrum and H. perforatum were 0.12, 0.20 and 0.21 mL/100 g dried material, respectively. The major constituents of the essential oils were α-pinene (12.52-49.96%), β-pinene (6.34-9.70%), (E)-β-ocimene (4.44-12.54%), β-caryophyllene (1.19-5.67%), and germacrene-D (2.34-6.92%). The essential oils of three Hypericum species indicated moderate-to-good inhibitory activities against four bacteria, especially against L. monocytogenes.

DISCUSSION AND CONCLUSION

The essential oils of the three studied Hypericum species sourced in alpine region of West Iran were rich in monoterpene and sesquiterpenes hydrocarbons. Among the three tested species, the essential oil of H. scabrum showed the highest antibacterial and antioxidant activities.

Authors+Show Affiliations

Department of Medicinal Plants, Shahrekord Branch, Researches Center of Medicinal Plants & Ethno-veterinary, Islamic Azad University , Shahrekord , Iran .No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24073965

Citation

Ghasemi Pirbalouti, Abdollah, et al. "Chemical Composition and Bioactivity of Essential Oils of Hypericum Helianthemoides, Hypericum Perforatum and Hypericum Scabrum." Pharmaceutical Biology, vol. 52, no. 2, 2014, pp. 175-81.
Ghasemi Pirbalouti A, Fatahi-Vanani M, Craker L, et al. Chemical composition and bioactivity of essential oils of Hypericum helianthemoides, Hypericum perforatum and Hypericum scabrum. Pharm Biol. 2014;52(2):175-81.
Ghasemi Pirbalouti, A., Fatahi-Vanani, M., Craker, L., & Shirmardi, H. (2014). Chemical composition and bioactivity of essential oils of Hypericum helianthemoides, Hypericum perforatum and Hypericum scabrum. Pharmaceutical Biology, 52(2), 175-81. https://doi.org/10.3109/13880209.2013.821663
Ghasemi Pirbalouti A, et al. Chemical Composition and Bioactivity of Essential Oils of Hypericum Helianthemoides, Hypericum Perforatum and Hypericum Scabrum. Pharm Biol. 2014;52(2):175-81. PubMed PMID: 24073965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and bioactivity of essential oils of Hypericum helianthemoides, Hypericum perforatum and Hypericum scabrum. AU - Ghasemi Pirbalouti,Abdollah, AU - Fatahi-Vanani,Maryam, AU - Craker,Lyle, AU - Shirmardi,Hamzeali, Y1 - 2013/09/30/ PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/9/2/medline SP - 175 EP - 81 JF - Pharmaceutical biology JO - Pharm Biol VL - 52 IS - 2 N2 - CONTEXT: A number Hypericum species are well known for their therapeutic efficacy and use in traditional medicine. The various species of Hypericum have been traditionally used for the treatment of wounds, eczema, burns, trauma, rheumatism, neuralgia, gastroenteritis, ulcers, hysteria, bedwetting and depression. OBJECTIVE: This study evaluated the in vitro antioxidant, antibacterial and phytochemical properties of essential oils of Hypericum helianthemoides (Spach) Boiss., Hypericum perforatum L. and Hypericum scabrum L. (Hypericaceae) collected from alpine region of Southwest Iran. MATERIALS AND METHODS: The essential oils obtained from dried flowering aerial parts of three Hypericum species were analyzed by gas chromatography and gas chromatography/mass spectrometry to determine chemical compositions. The antibacterial activity of essential oils within concentration ranges from 16 to 500 µg/mL was individually evaluated against Bacillus cereus, Listeria monocytogenes. Proteus vulgaris and Salmonella typhimurium. The 1,1-diphenyl-2-picrilhydrazyl (DPPH) radical scavenging activity of essential oils was determined using DPPH assay. RESULTS: Essential oil yield of H. helianthemoides. H. scabrum and H. perforatum were 0.12, 0.20 and 0.21 mL/100 g dried material, respectively. The major constituents of the essential oils were α-pinene (12.52-49.96%), β-pinene (6.34-9.70%), (E)-β-ocimene (4.44-12.54%), β-caryophyllene (1.19-5.67%), and germacrene-D (2.34-6.92%). The essential oils of three Hypericum species indicated moderate-to-good inhibitory activities against four bacteria, especially against L. monocytogenes. DISCUSSION AND CONCLUSION: The essential oils of the three studied Hypericum species sourced in alpine region of West Iran were rich in monoterpene and sesquiterpenes hydrocarbons. Among the three tested species, the essential oil of H. scabrum showed the highest antibacterial and antioxidant activities. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/24073965/Chemical_composition_and_bioactivity_of_essential_oils_of_Hypericum_helianthemoides_Hypericum_perforatum_and_Hypericum_scabrum_ DB - PRIME DP - Unbound Medicine ER -