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D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.
Nutr Res. 2013 Oct; 33(10):803-10.NR

Abstract

It was hypothesized that D-aspartic acid (D-ASP) supplementation would not increase endogenous testosterone levels or improve muscular performance associated with resistance training. Therefore, body composition, muscle strength, and serum hormone levels associated with the hypothalamo-pituitary-gonadal axis were studied after 28 days of resistance training and D-ASP supplementation. Resistance-trained men resistance trained 4 times/wk for 28 days while orally ingesting either 3 g of placebo or 3 g of D-ASP. Data were analyzed with 2 × 2 analysis of variance (P < .05). Before and after resistance training and supplementation, body composition and muscle strength, serum gonadal hormones, and serum D-ASP and d-aspartate oxidase (DDO) were determined. Body composition and muscle strength were significantly increased in both groups in response to resistance training (P < .05) but not different from one another (P > .05). Total and free testosterone, luteinizing hormone, gonadotropin-releasing hormone, and estradiol were unchanged with resistance training and D-ASP supplementation (P > .05). For serum D-ASP and DDO, D-ASP resulted in a slight increase compared with baseline levels (P > .05). For the D-ASP group, the levels of serum DDO were significantly increased compared with placebo (P < .05). The gonadal hormones were unaffected by 28 days of D-ASP supplementation and not associated with the observed increases in muscle strength and mass. Therefore, at the dose provided, D-ASP supplementation is ineffective in up-regulating the activity of the hypothalamo-pituitary-gonadal axis and has no anabolic or ergogenic effects in skeletal muscle.

Authors+Show Affiliations

Department of Health, Exercise and Biochemical Nutrition Lab, Human Performance, and Recreation, Baylor University, Waco, TX, USA. Electronic address: darryn_willoughby@baylor.edu.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24074738

Citation

Willoughby, Darryn S., and Brian Leutholtz. "D-aspartic Acid Supplementation Combined With 28 Days of Heavy Resistance Training Has No Effect On Body Composition, Muscle Strength, and Serum Hormones Associated With the Hypothalamo-pituitary-gonadal Axis in Resistance-trained Men." Nutrition Research (New York, N.Y.), vol. 33, no. 10, 2013, pp. 803-10.
Willoughby DS, Leutholtz B. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutr Res. 2013;33(10):803-10.
Willoughby, D. S., & Leutholtz, B. (2013). D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutrition Research (New York, N.Y.), 33(10), 803-10. https://doi.org/10.1016/j.nutres.2013.07.010
Willoughby DS, Leutholtz B. D-aspartic Acid Supplementation Combined With 28 Days of Heavy Resistance Training Has No Effect On Body Composition, Muscle Strength, and Serum Hormones Associated With the Hypothalamo-pituitary-gonadal Axis in Resistance-trained Men. Nutr Res. 2013;33(10):803-10. PubMed PMID: 24074738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. AU - Willoughby,Darryn S, AU - Leutholtz,Brian, Y1 - 2013/08/15/ PY - 2013/06/06/received PY - 2013/07/11/revised PY - 2013/07/13/accepted PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/4/5/medline KW - 1 repetition maximum KW - 1-RM KW - BSA KW - D-ASP KW - DDO KW - ELISA KW - Estradiol KW - GnRH KW - H(2)O(2) KW - HCL KW - HPG axis KW - LH KW - Luteinizing hormone KW - N-methyl d-aspartic acid KW - NMDA KW - Resistance training KW - Testosterone KW - bovine serum albumin KW - d-Aspartic acid KW - d-aspartate oxidase KW - d-aspartic acid KW - enzyme-linked immunoabsorbent assay KW - gonadotropin-releasing hormone KW - hydrochloric acid KW - hydrogen peroxide KW - hypothalamo-pituitary-gonadal axis KW - luteinizing hormone SP - 803 EP - 10 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 33 IS - 10 N2 - It was hypothesized that D-aspartic acid (D-ASP) supplementation would not increase endogenous testosterone levels or improve muscular performance associated with resistance training. Therefore, body composition, muscle strength, and serum hormone levels associated with the hypothalamo-pituitary-gonadal axis were studied after 28 days of resistance training and D-ASP supplementation. Resistance-trained men resistance trained 4 times/wk for 28 days while orally ingesting either 3 g of placebo or 3 g of D-ASP. Data were analyzed with 2 × 2 analysis of variance (P < .05). Before and after resistance training and supplementation, body composition and muscle strength, serum gonadal hormones, and serum D-ASP and d-aspartate oxidase (DDO) were determined. Body composition and muscle strength were significantly increased in both groups in response to resistance training (P < .05) but not different from one another (P > .05). Total and free testosterone, luteinizing hormone, gonadotropin-releasing hormone, and estradiol were unchanged with resistance training and D-ASP supplementation (P > .05). For serum D-ASP and DDO, D-ASP resulted in a slight increase compared with baseline levels (P > .05). For the D-ASP group, the levels of serum DDO were significantly increased compared with placebo (P < .05). The gonadal hormones were unaffected by 28 days of D-ASP supplementation and not associated with the observed increases in muscle strength and mass. Therefore, at the dose provided, D-ASP supplementation is ineffective in up-regulating the activity of the hypothalamo-pituitary-gonadal axis and has no anabolic or ergogenic effects in skeletal muscle. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24074738/D_aspartic_acid_supplementation_combined_with_28_days_of_heavy_resistance_training_has_no_effect_on_body_composition_muscle_strength_and_serum_hormones_associated_with_the_hypothalamo_pituitary_gonadal_axis_in_resistance_trained_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00173-5 DB - PRIME DP - Unbound Medicine ER -