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Disturbance in venous outflow from the cerebral circulation intensifies the release of blood-brain barrier injury biomarkers in patients undergoing cardiac surgery.

Abstract

OBJECTIVE

Disturbances in venous outflow from the cerebral circulation may result in brain injury. Severe increases in brain venous pressure lead to brain ischemia and, subsequently, brain edema and intracranial hemorrhages. The purpose of this study was to determine the effect of changes in jugular venous bulb pressure (JVBP) on plasma blood brain-barrier biomarkers concentration and disturbances in arteriovenous total and ionized magnesium (a-vtMg and a-viMg) in brain circulation in patients undergoing coronary artery bypass grafting surgery (CABG) with cardiopulmonary bypass (CPB).

DESIGN

Prospective observational study.

SETTING

Department of Cardiac Surgery at a Medical University Hospital.

PARTICIPANTS

Ninety-two adult patients undergoing elective CABG with CPB under general anaesthesia were studied.

METHODS

Central venous pressure (CVP) was measured using a pulmonary artery catheter. The right jugular vein was cannulized retrogradely for jugular venous bulb pressure (JVBP) measurement. Concentrations of plasma S100β protein, matrix metalloproteinase 9 (MMP-9), creatine kinase isoenzyme BB (CK-BB) a-vtMg and a-viMg were measured as the markers of blood-brain barrier dysfunction. All of them were analyzed in comparison with JVBP during surgery and the early postoperative period.

RESULTS

Elevated JVBP was noted after CPB and after surgery. Its increase above 12 mmHg intensified release of S100β, MMP-9 and CK-BB as well as disorders in a-vtMg and a-viMg. CVP correlated with JVBP, S100β, and MMP-9. Moreover, JVBP correlated with S100β and MMP-9.

CONCLUSIONS

Cardiac surgery increased JVBP, and JVBP elevated above 12 mmHg intensified an increase in biomarkers of plasma blood-brain barrier disruption.

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    MeSH

    Aged
    Anesthesia
    Biological Markers
    Blood Pressure
    Blood-Brain Barrier
    Cardiac Surgical Procedures
    Cardiopulmonary Bypass
    Catheterization, Swan-Ganz
    Central Venous Pressure
    Cerebral Veins
    Cerebrovascular Circulation
    Creatine Kinase, BB Form
    Female
    Humans
    Jugular Veins
    Magnesium
    Male
    Matrix Metalloproteinase 9
    Middle Aged
    Preanesthetic Medication
    Prospective Studies
    S100 Calcium Binding Protein beta Subunit
    Spectrophotometry, Ultraviolet
    Surgical Procedures, Elective

    Pub Type(s)

    Journal Article
    Observational Study

    Language

    eng

    PubMed ID

    24075637