Tags

Type your tag names separated by a space and hit enter

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation.
Prog Lipid Res. 2013 Oct; 52(4):633-50.PL

Abstract

Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted the attention of human civilizations for centuries, much earlier than the discovery and characterization of their substrate of action, the endocannabinoid system (ECS). The latter is an ensemble of endogenous lipids, their receptors [in particular type-1 (CB1) and type-2 (CB2) cannabinoid receptors] and metabolic enzymes. Cannabinoid signaling regulates cell proliferation, differentiation and survival, with different outcomes depending on the molecular targets and cellular context involved. Cannabinoid receptors are expressed and functional from the very early developmental stages, when they regulate embryonic and trophoblast stem cell survival and differentiation, and thus may affect the formation of manifold adult specialized tissues derived from the three different germ layers (ectoderm, mesoderm and endoderm). In the ectoderm-derived nervous system, both CB1 and CB2 receptors are present in neural progenitor/stem cells and control their self-renewal, proliferation and differentiation. CB1 and CB2 show opposite patterns of expression, the former increasing and the latter decreasing along neuronal differentiation. Recently, endocannabinoid (eCB) signaling has also been shown to regulate proliferation and differentiation of mesoderm-derived hematopoietic and mesenchymal stem cells, with a key role in determining the formation of several cell types in peripheral tissues, including blood cells, adipocytes, osteoblasts/osteoclasts and epithelial cells. Here, we will review these new findings, which unveil the involvement of eCB signaling in the regulation of progenitor/stem cell fate in the nervous system and in the periphery. The developmental regulation of cannabinoid receptor expression and cellular/subcellular localization, together with their role in progenitor/stem cell biology, may have important implications in human health and disease.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, IUIN, CIBERNED and IRYCIS, 28040 Madrid, Spain. Electronic address: igr@quim.ucm.es.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24076098

Citation

Galve-Roperh, Ismael, et al. "Cannabinoid Receptor Signaling in Progenitor/stem Cell Proliferation and Differentiation." Progress in Lipid Research, vol. 52, no. 4, 2013, pp. 633-50.
Galve-Roperh I, Chiurchiù V, Díaz-Alonso J, et al. Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Prog Lipid Res. 2013;52(4):633-50.
Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., & Maccarrone, M. (2013). Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Progress in Lipid Research, 52(4), 633-50. https://doi.org/10.1016/j.plipres.2013.05.004
Galve-Roperh I, et al. Cannabinoid Receptor Signaling in Progenitor/stem Cell Proliferation and Differentiation. Prog Lipid Res. 2013;52(4):633-50. PubMed PMID: 24076098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. AU - Galve-Roperh,Ismael, AU - Chiurchiù,Valerio, AU - Díaz-Alonso,Javier, AU - Bari,Monica, AU - Guzmán,Manuel, AU - Maccarrone,Mauro, Y1 - 2013/09/25/ PY - 2013/02/26/received PY - 2013/05/28/accepted PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/6/21/medline KW - 2-AG KW - 2-arachidonoylglycerol KW - AEA KW - BDNF KW - CBD KW - CBG KW - CFU-GEMM KW - CREB KW - CSF KW - Cell commitment KW - Cell survival KW - DAGL KW - ECB KW - ECS KW - ERK KW - ES KW - Endocannabinoids KW - FAAH KW - FGF KW - GAD KW - GSK3β KW - HPC KW - HSC KW - ICM KW - L1-CAM KW - L1-cell adhesion molecule KW - MAGL KW - Membrane receptors KW - N-arachidonoylethanolamine KW - N-oleoylethanolamine KW - N-palmitoylethanolamine KW - NCAM KW - NGF KW - NP KW - Niche cues KW - OEA KW - PEA KW - PI3K KW - PKA KW - PPARγ KW - Protein kinases KW - RANKL KW - SVZ KW - THC KW - Transcription factors KW - VZ KW - brain derived neurotrophic factor KW - cAMP response element-binding protein KW - cannabidiol KW - cannabigerol KW - colony-forming unit: granulocyte, erythrocyte, macrophage, megakaryocyte KW - colony-stimulating factors KW - diacylglycerol lipase KW - embryonic stem KW - endocannabinoid KW - endocannabinoid system KW - extracellular-signaling regulated protein kinase KW - fatty acid amide hydrolase KW - fibroblast growth factor KW - glutamate decarboxylase KW - glycogen synthase kina KW - hematopoietic progenitor cells KW - hematopoietic stem cells KW - inner cell mass KW - mGluR KW - mTORC1 KW - mammalian target of rapamycin complex 1 KW - metabotropic glutamate receptors KW - monoacylglycerol lipase KW - nerve growth factor KW - neural cell adhesion molecule KW - neural progenitor/stem cell KW - peroxisome proliferator activated receptors KW - phosphoinositol 3-kinase KW - protein kinase-A KW - receptor activator of nuclear factor kappa-B ligand KW - subventricular zone KW - vGlut KW - ventricular zone KW - vesicular glutamate transporter KW - Δ(9)-tetrahydrocannabinol SP - 633 EP - 50 JF - Progress in lipid research JO - Prog. Lipid Res. VL - 52 IS - 4 N2 - Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted the attention of human civilizations for centuries, much earlier than the discovery and characterization of their substrate of action, the endocannabinoid system (ECS). The latter is an ensemble of endogenous lipids, their receptors [in particular type-1 (CB1) and type-2 (CB2) cannabinoid receptors] and metabolic enzymes. Cannabinoid signaling regulates cell proliferation, differentiation and survival, with different outcomes depending on the molecular targets and cellular context involved. Cannabinoid receptors are expressed and functional from the very early developmental stages, when they regulate embryonic and trophoblast stem cell survival and differentiation, and thus may affect the formation of manifold adult specialized tissues derived from the three different germ layers (ectoderm, mesoderm and endoderm). In the ectoderm-derived nervous system, both CB1 and CB2 receptors are present in neural progenitor/stem cells and control their self-renewal, proliferation and differentiation. CB1 and CB2 show opposite patterns of expression, the former increasing and the latter decreasing along neuronal differentiation. Recently, endocannabinoid (eCB) signaling has also been shown to regulate proliferation and differentiation of mesoderm-derived hematopoietic and mesenchymal stem cells, with a key role in determining the formation of several cell types in peripheral tissues, including blood cells, adipocytes, osteoblasts/osteoclasts and epithelial cells. Here, we will review these new findings, which unveil the involvement of eCB signaling in the regulation of progenitor/stem cell fate in the nervous system and in the periphery. The developmental regulation of cannabinoid receptor expression and cellular/subcellular localization, together with their role in progenitor/stem cell biology, may have important implications in human health and disease. SN - 1873-2194 UR - https://www.unboundmedicine.com/medline/citation/24076098/Cannabinoid_receptor_signaling_in_progenitor/stem_cell_proliferation_and_differentiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-7827(13)00054-4 DB - PRIME DP - Unbound Medicine ER -