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Characterization of fluoxetine effects on ethanol withdrawal-induced cortical hyperexcitability by EEG spectral power in rats.
Neuropharmacology. 2014 Feb; 77:49-56.N

Abstract

Antidepressants have been used for treatment of ethanol withdrawal symptoms mainly in observational studies. However, cortical frequency oscillation of ethanol withdrawal treatment with antidepressants remained to be elucidated. This study aimed to identify surrogate biomarkers that represent intact biological or ethanol withdrawal processes and response to pretreatment with fluoxetine, a selective serotonin reuptake inhibitor, with quantitative methods. Adult male Wistar rats implanted with electrodes over the frontal and parietal cortices were rendered dependent on ethanol via modified liquid diet (MLD) containing ethanol. Then, ethanol-containing MLD was replaced with isocaloric ethanol-free MLD to induce ethanol withdrawal symptoms. Locomotor activity, sleep-wakefulness and spectral frequencies of electroencephalographic (EEG) pattern during ethanol-withdrawal period were analyzed. One-way ANOVA confirmed significant increases in locomotor activity and time spent in awake state and decreases time spent in non-rapid eye movement (NREM) sleep and REM-sleep during ethanol withdrawal period. Fast Fourier Transformation also revealed predominant increases in gamma spectral powers within both the frontal and parietal cortices during ethanol withdrawal. However, these changes, except sleep-wake disturbances, were significantly attenuated by fluoxetine pretreatment (10 mg/kg). The present study supports the hypothesis that serotonergic hypofunction may underlie most of ethanol withdrawal symptoms and proposes that electroencephalographic patterns are valid biomarkers for ethanol withdrawal evaluation and treatment.

Authors+Show Affiliations

Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat-Yai, Songkhla 90112, Thailand.Department of Pharmacology, Faculty of Science, Prince of Songkla University (PSU), Hat-Yai, Songkhla 90112, Thailand.Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat-Yai, Songkhla 90112, Thailand. Electronic address: ekumarnsit@yahoo.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24076335

Citation

Cheaha, Dania, et al. "Characterization of Fluoxetine Effects On Ethanol Withdrawal-induced Cortical Hyperexcitability By EEG Spectral Power in Rats." Neuropharmacology, vol. 77, 2014, pp. 49-56.
Cheaha D, Sawangjaroen K, Kumarnsit E. Characterization of fluoxetine effects on ethanol withdrawal-induced cortical hyperexcitability by EEG spectral power in rats. Neuropharmacology. 2014;77:49-56.
Cheaha, D., Sawangjaroen, K., & Kumarnsit, E. (2014). Characterization of fluoxetine effects on ethanol withdrawal-induced cortical hyperexcitability by EEG spectral power in rats. Neuropharmacology, 77, 49-56. https://doi.org/10.1016/j.neuropharm.2013.09.020
Cheaha D, Sawangjaroen K, Kumarnsit E. Characterization of Fluoxetine Effects On Ethanol Withdrawal-induced Cortical Hyperexcitability By EEG Spectral Power in Rats. Neuropharmacology. 2014;77:49-56. PubMed PMID: 24076335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of fluoxetine effects on ethanol withdrawal-induced cortical hyperexcitability by EEG spectral power in rats. AU - Cheaha,Dania, AU - Sawangjaroen,Kitja, AU - Kumarnsit,Ekkasit, Y1 - 2013/09/25/ PY - 2013/06/24/received PY - 2013/08/18/revised PY - 2013/09/16/accepted PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/8/27/medline KW - EEG KW - Ethanol withdrawal KW - Fluoxetine KW - Gamma oscillation KW - Serotonin SP - 49 EP - 56 JF - Neuropharmacology JO - Neuropharmacology VL - 77 N2 - Antidepressants have been used for treatment of ethanol withdrawal symptoms mainly in observational studies. However, cortical frequency oscillation of ethanol withdrawal treatment with antidepressants remained to be elucidated. This study aimed to identify surrogate biomarkers that represent intact biological or ethanol withdrawal processes and response to pretreatment with fluoxetine, a selective serotonin reuptake inhibitor, with quantitative methods. Adult male Wistar rats implanted with electrodes over the frontal and parietal cortices were rendered dependent on ethanol via modified liquid diet (MLD) containing ethanol. Then, ethanol-containing MLD was replaced with isocaloric ethanol-free MLD to induce ethanol withdrawal symptoms. Locomotor activity, sleep-wakefulness and spectral frequencies of electroencephalographic (EEG) pattern during ethanol-withdrawal period were analyzed. One-way ANOVA confirmed significant increases in locomotor activity and time spent in awake state and decreases time spent in non-rapid eye movement (NREM) sleep and REM-sleep during ethanol withdrawal period. Fast Fourier Transformation also revealed predominant increases in gamma spectral powers within both the frontal and parietal cortices during ethanol withdrawal. However, these changes, except sleep-wake disturbances, were significantly attenuated by fluoxetine pretreatment (10 mg/kg). The present study supports the hypothesis that serotonergic hypofunction may underlie most of ethanol withdrawal symptoms and proposes that electroencephalographic patterns are valid biomarkers for ethanol withdrawal evaluation and treatment. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/24076335/Characterization_of_fluoxetine_effects_on_ethanol_withdrawal_induced_cortical_hyperexcitability_by_EEG_spectral_power_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(13)00427-9 DB - PRIME DP - Unbound Medicine ER -