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IL-33 mediates the expressions of IL-5 and IL-13 in Angiostrongylus cantonensis-infected mice.
Exp Parasitol. 2013 Nov; 135(3):587-94.EP

Abstract

Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. C57BL/6 mice were experimentally infected with 35 infectious larvae. Two groups of infected mice received intraperitoneal injections of mouse IL-33 (1μg) or anti-IL-33 monoclonal antibody (mAb) (10μg) 3days post infection (dpi) and subsequent booster shots of the same dose at 5day intervals. Blood samples from each group were collected weekly for assays. IgE levels were significantly increased in all infected mice. The eosinophil percentage and levels of IL-5 and IL-13 significantly increased in the IL-33-treated group relative to infected but non-treated animals. The level of IL-5 decreased in the mAb-treated group. The severity of eosinophilic meningitis was exacerbated in the IL-33 injected group. Taken together, these results suggest that IL-33 mediates the expressions of IL-5 and IL-13, and plays a crucial role in the pathogenesis of angiostrongylosis.

Authors+Show Affiliations

School of Medicine, Fu Jen Catholic University, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24076431

Citation

Du, Wen-Yuan, et al. "IL-33 Mediates the Expressions of IL-5 and IL-13 in Angiostrongylus Cantonensis-infected Mice." Experimental Parasitology, vol. 135, no. 3, 2013, pp. 587-94.
Du WY, Chen CW, Lin FK, et al. IL-33 mediates the expressions of IL-5 and IL-13 in Angiostrongylus cantonensis-infected mice. Exp Parasitol. 2013;135(3):587-94.
Du, W. Y., Chen, C. W., Lin, F. K., & Chuang, C. C. (2013). IL-33 mediates the expressions of IL-5 and IL-13 in Angiostrongylus cantonensis-infected mice. Experimental Parasitology, 135(3), 587-94. https://doi.org/10.1016/j.exppara.2013.09.012
Du WY, et al. IL-33 Mediates the Expressions of IL-5 and IL-13 in Angiostrongylus Cantonensis-infected Mice. Exp Parasitol. 2013;135(3):587-94. PubMed PMID: 24076431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-33 mediates the expressions of IL-5 and IL-13 in Angiostrongylus cantonensis-infected mice. AU - Du,Wen-Yuan, AU - Chen,Chi-Wu, AU - Lin,Feng-Kuan, AU - Chuang,Chih-Cheng, Y1 - 2013/09/27/ PY - 2013/05/29/received PY - 2013/08/16/revised PY - 2013/09/06/accepted PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/1/7/medline KW - Angiostrongylus cantonensis KW - IL-33 SP - 587 EP - 94 JF - Experimental parasitology JO - Exp Parasitol VL - 135 IS - 3 N2 - Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. C57BL/6 mice were experimentally infected with 35 infectious larvae. Two groups of infected mice received intraperitoneal injections of mouse IL-33 (1μg) or anti-IL-33 monoclonal antibody (mAb) (10μg) 3days post infection (dpi) and subsequent booster shots of the same dose at 5day intervals. Blood samples from each group were collected weekly for assays. IgE levels were significantly increased in all infected mice. The eosinophil percentage and levels of IL-5 and IL-13 significantly increased in the IL-33-treated group relative to infected but non-treated animals. The level of IL-5 decreased in the mAb-treated group. The severity of eosinophilic meningitis was exacerbated in the IL-33 injected group. Taken together, these results suggest that IL-33 mediates the expressions of IL-5 and IL-13, and plays a crucial role in the pathogenesis of angiostrongylosis. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/24076431/IL_33_mediates_the_expressions_of_IL_5_and_IL_13_in_Angiostrongylus_cantonensis_infected_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(13)00250-6 DB - PRIME DP - Unbound Medicine ER -