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Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not widespread pressure pain sensitivity, in women with carpal Tunnel syndrome.

Abstract

BACKGROUND

The genetic influence of Val158Met polymorphisms, one of the potential genetic determinants for nociceptive processing, has not been previously investigated in women with carpal tunnel syndrome (CTS).

OBJECTIVES

To investigate the association between the Val158Met polymorphism with CTS and to assess the relationship between the Val158Met polymorphism and the clinical outcomes and widespread pressure pain hypersensitivity in women with CTS.

STUDY DESIGN

Case control study.

SETTING

Neurology department at an urban hospital.

METHOD

One hundred nine (n = 109) women (mean age: 47 ± 9 years) with a clinical and electrodiagnostic diagnosis of CTS and 109 matched healthy women participated. After amplifying the Val158Met polymorphism by polymerase chain reactions, rs4680 genotype frequencies and allele distributions were calculated. We classified individuals according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. The intensity of the pain was assessed with a numeric rating scale (0-10) and disability was determined with the Boston Carpal Tunnel Questionnaire. Pressure pain thresholds were bilaterally assessed over median, radial, and ulnar nerve trunks; C5-C6 facet joints; and carpal tunnel and tibialis anterior muscles.Institutional Review Board: The study project was approved by the local human research committee (HUFA-12/14). All participants signed an informed consent prior to their inclusion in the study.

RESULTS

The distribution of the 3 Val158Met genotypes (Val/Val, Val/Met, Met/Met) and alleles was not significantly different between women with CTS and healthy women (Chi-Square = 0.498; P = 0.780). Women with CTS carrying the Met/Met genotype showed higher levels of pain and disability than those with the Val/Met genotype (P < 0.01) and with the Val/Val genotype (P < 0.001). No differences in the years with pain (P = 0.954), age (P = 0.740), depression (P = 0.530), severity of CTS (P = 0.744) or presence of unilateral-bilateral symptoms (P = 0.279) existed depending on the rs4680 Val158Met genotype. No significant differences in widespread pressure pain sensitivity were observed in any of the points depending on the rs4680 Val158Met genotype (P > 0.315).

LIMITATIONS

We only recruited women from a specialized department.

CONCLUSION

Current results indicated that the Val158Met polymorphism seems not to be a risk factor for the development of CTS; however, it was associated with increased perception of pain and higher disability scores.

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  • Authors+Show Affiliations

    ,

    Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorc-n, Madrid, Spain; Esthesiology Laboratory of Universidad Rey Juan Carlos, Alcorc-n, Spain;Department of Neurology, Hospital Uni.

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    Source

    Pain physician 16:5 pg E591-600

    MeSH

    Adult
    Aged
    Carpal Tunnel Syndrome
    Case-Control Studies
    Catechol O-Methyltransferase
    Female
    Genetic Predisposition to Disease
    Genotype
    Humans
    Middle Aged
    Pain
    Pain Measurement
    Pain Threshold
    Polymorphism, Genetic
    Surveys and Questionnaires

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24077209

    Citation

    Fernández-de-las-Peñas, César, et al. "Catechol-O-methyltransferase Val158Met Polymorphism Is Associated With Pain and Disability, but Not Widespread Pressure Pain Sensitivity, in Women With Carpal Tunnel Syndrome." Pain Physician, vol. 16, no. 5, 2013, pp. E591-600.
    Fernández-de-las-Peñas C, Ambite-Quesada S, Ortega-Santiago R, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not widespread pressure pain sensitivity, in women with carpal Tunnel syndrome. Pain Physician. 2013;16(5):E591-600.
    Fernández-de-las-Peñas, C., Ambite-Quesada, S., Ortega-Santiago, R., Martínez-Perez, A., Díaz, H. F., Martínez-Martín, J., & Parejam, J. A. (2013). Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not widespread pressure pain sensitivity, in women with carpal Tunnel syndrome. Pain Physician, 16(5), pp. E591-600.
    Fernández-de-las-Peñas C, et al. Catechol-O-methyltransferase Val158Met Polymorphism Is Associated With Pain and Disability, but Not Widespread Pressure Pain Sensitivity, in Women With Carpal Tunnel Syndrome. Pain Physician. 2013;16(5):E591-600. PubMed PMID: 24077209.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not widespread pressure pain sensitivity, in women with carpal Tunnel syndrome. AU - Fernández-de-las-Peñas,César, AU - Ambite-Quesada,Silvia, AU - Ortega-Santiago,Ricardo, AU - Martínez-Perez,Almudena, AU - Díaz,Homid Fahandezh-Saddi, AU - Martínez-Martín,Javier, AU - Parejam,Juan A, PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/5/23/medline SP - E591 EP - 600 JF - Pain physician JO - Pain Physician VL - 16 IS - 5 N2 - BACKGROUND: The genetic influence of Val158Met polymorphisms, one of the potential genetic determinants for nociceptive processing, has not been previously investigated in women with carpal tunnel syndrome (CTS). OBJECTIVES: To investigate the association between the Val158Met polymorphism with CTS and to assess the relationship between the Val158Met polymorphism and the clinical outcomes and widespread pressure pain hypersensitivity in women with CTS. STUDY DESIGN: Case control study. SETTING: Neurology department at an urban hospital. METHOD: One hundred nine (n = 109) women (mean age: 47 ± 9 years) with a clinical and electrodiagnostic diagnosis of CTS and 109 matched healthy women participated. After amplifying the Val158Met polymorphism by polymerase chain reactions, rs4680 genotype frequencies and allele distributions were calculated. We classified individuals according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. The intensity of the pain was assessed with a numeric rating scale (0-10) and disability was determined with the Boston Carpal Tunnel Questionnaire. Pressure pain thresholds were bilaterally assessed over median, radial, and ulnar nerve trunks; C5-C6 facet joints; and carpal tunnel and tibialis anterior muscles.Institutional Review Board: The study project was approved by the local human research committee (HUFA-12/14). All participants signed an informed consent prior to their inclusion in the study. RESULTS: The distribution of the 3 Val158Met genotypes (Val/Val, Val/Met, Met/Met) and alleles was not significantly different between women with CTS and healthy women (Chi-Square = 0.498; P = 0.780). Women with CTS carrying the Met/Met genotype showed higher levels of pain and disability than those with the Val/Met genotype (P < 0.01) and with the Val/Val genotype (P < 0.001). No differences in the years with pain (P = 0.954), age (P = 0.740), depression (P = 0.530), severity of CTS (P = 0.744) or presence of unilateral-bilateral symptoms (P = 0.279) existed depending on the rs4680 Val158Met genotype. No significant differences in widespread pressure pain sensitivity were observed in any of the points depending on the rs4680 Val158Met genotype (P > 0.315). LIMITATIONS: We only recruited women from a specialized department. CONCLUSION: Current results indicated that the Val158Met polymorphism seems not to be a risk factor for the development of CTS; however, it was associated with increased perception of pain and higher disability scores. SN - 2150-1149 UR - https://www.unboundmedicine.com/medline/citation/24077209/Catechol_O_methyltransferase_Val158Met_polymorphism_is_associated_with_pain_and_disability_but_not_widespread_pressure_pain_sensitivity_in_women_with_carpal_Tunnel_syndrome_ L2 - http://www.painphysicianjournal.com/linkout?issn=1533-3159&amp;vol=16&amp;page=E591 DB - PRIME DP - Unbound Medicine ER -