Tags

Type your tag names separated by a space and hit enter

Salivary nerve growth factor reactivity to acute psychosocial stress: a new frontier for stress research.
Psychosom Med. 2013 Oct; 75(8):744-50.PM

Abstract

OBJECTIVE

Neurotrophins such as nerve growth factor (NGF) may represent a stress-responsive system complementing the better known neuroendocrine (hypothalamic-pituitary-adrenal axis) and autonomic nervous system, but there is little evidence for NGF response to acute stress in humans because noninvasive measures have not been available. We investigated salivary NGF (sNGF) in 40 healthy young adults confronting a romantic conflict stressor.

METHODS

Five saliva samples-two collected before and three after the conflict-were assayed for sNGF, cortisol (hypothalamic-pituitary-adrenal marker), and α-amylase (sAA; ANS marker). In addition, a control group (n = 20) gave saliva samples at the same time intervals to determine whether sNGF changes were specific to the conflict stressor.

RESULTS

sNGF showed significant reactivity from entry to the first poststress sample among study participants (β = .13, p = .001), with nonsignificant change across poststress samples. Control participants showed no change in sNGF across the same period. Within-person changes in sNGF were generally aligned with both cortisol (β = .17, p = .003) and sAA (β = .17, p = .021) responses. Preconflict negative emotion predicted lower sNGF reactivity (β = -.08, p = .009) and less alignment with sAA (β = -.09, p = .040), whereas positive emotion predicted less alignment with cortisol (β = -.10, p = .019).

CONCLUSIONS

This study is the first to document sNGF as a marker that responds to stress in humans.

Authors+Show Affiliations

Psychology Department, University of Oregon, 1227, Eugene, OR 97403. hlaurent@uoregon.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24077771

Citation

Laurent, Heidemarie K., et al. "Salivary Nerve Growth Factor Reactivity to Acute Psychosocial Stress: a New Frontier for Stress Research." Psychosomatic Medicine, vol. 75, no. 8, 2013, pp. 744-50.
Laurent HK, Laurent SM, Granger DA. Salivary nerve growth factor reactivity to acute psychosocial stress: a new frontier for stress research. Psychosom Med. 2013;75(8):744-50.
Laurent, H. K., Laurent, S. M., & Granger, D. A. (2013). Salivary nerve growth factor reactivity to acute psychosocial stress: a new frontier for stress research. Psychosomatic Medicine, 75(8), 744-50. https://doi.org/10.1097/PSY.0b013e3182a85ffd
Laurent HK, Laurent SM, Granger DA. Salivary Nerve Growth Factor Reactivity to Acute Psychosocial Stress: a New Frontier for Stress Research. Psychosom Med. 2013;75(8):744-50. PubMed PMID: 24077771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary nerve growth factor reactivity to acute psychosocial stress: a new frontier for stress research. AU - Laurent,Heidemarie K, AU - Laurent,Sean M, AU - Granger,Douglas A, Y1 - 2013/09/27/ PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/4/30/medline KW - ANS KW - HPA KW - cortisol KW - nerve growth factor KW - stress KW - α-amylase SP - 744 EP - 50 JF - Psychosomatic medicine JO - Psychosom Med VL - 75 IS - 8 N2 - OBJECTIVE: Neurotrophins such as nerve growth factor (NGF) may represent a stress-responsive system complementing the better known neuroendocrine (hypothalamic-pituitary-adrenal axis) and autonomic nervous system, but there is little evidence for NGF response to acute stress in humans because noninvasive measures have not been available. We investigated salivary NGF (sNGF) in 40 healthy young adults confronting a romantic conflict stressor. METHODS: Five saliva samples-two collected before and three after the conflict-were assayed for sNGF, cortisol (hypothalamic-pituitary-adrenal marker), and α-amylase (sAA; ANS marker). In addition, a control group (n = 20) gave saliva samples at the same time intervals to determine whether sNGF changes were specific to the conflict stressor. RESULTS: sNGF showed significant reactivity from entry to the first poststress sample among study participants (β = .13, p = .001), with nonsignificant change across poststress samples. Control participants showed no change in sNGF across the same period. Within-person changes in sNGF were generally aligned with both cortisol (β = .17, p = .003) and sAA (β = .17, p = .021) responses. Preconflict negative emotion predicted lower sNGF reactivity (β = -.08, p = .009) and less alignment with sAA (β = -.09, p = .040), whereas positive emotion predicted less alignment with cortisol (β = -.10, p = .019). CONCLUSIONS: This study is the first to document sNGF as a marker that responds to stress in humans. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/24077771/Salivary_nerve_growth_factor_reactivity_to_acute_psychosocial_stress:_a_new_frontier_for_stress_research_ L2 - https://doi.org/10.1097/PSY.0b013e3182a85ffd DB - PRIME DP - Unbound Medicine ER -