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Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats.
Mol Cell Biochem. 2014 Jan; 385(1-2):159-68.MC

Abstract

Epidemiological studies have demonstrated that diabetes mellitus is a serious health burden for both governments and healthcare providers. This study was hypothesized to evaluate the antihyperglycemic potential of eugenol by determine the activities of key enzymes of glucose metabolism in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg body weight (b.w.)). Eugenol was administered to diabetic rats intragastrically at 2.5, 5, and 10 mg/kg b.w. for 30 days. The dose 10 mg/kg b.w. significantly reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) and increased plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and liver marker enzymes (AST, ALT, and ALP), creatine kinase and blood urea nitrogen in serum and blood of diabetic rats were significantly reverted to near normal levels by the administration of eugenol. Further, eugenol administration to diabetic rats improved body weight and hepatic glycogen content demonstrated the antihyperglycemic potential of eugenol in diabetic rats. The present findings suggest that eugenol can potentially ameliorate key enzymes of glucose metabolism in experimental diabetes, and it is sensible to broaden the scale of use of eugenol in a trial to alleviate the adverse effects of diabetes.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24078031

Citation

Srinivasan, Subramani, et al. "Ameliorating Effect of Eugenol On Hyperglycemia By Attenuating the Key Enzymes of Glucose Metabolism in Streptozotocin-induced Diabetic Rats." Molecular and Cellular Biochemistry, vol. 385, no. 1-2, 2014, pp. 159-68.
Srinivasan S, Sathish G, Jayanthi M, et al. Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Mol Cell Biochem. 2014;385(1-2):159-68.
Srinivasan, S., Sathish, G., Jayanthi, M., Muthukumaran, J., Muruganathan, U., & Ramachandran, V. (2014). Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Molecular and Cellular Biochemistry, 385(1-2), 159-68.
Srinivasan S, et al. Ameliorating Effect of Eugenol On Hyperglycemia By Attenuating the Key Enzymes of Glucose Metabolism in Streptozotocin-induced Diabetic Rats. Mol Cell Biochem. 2014;385(1-2):159-68. PubMed PMID: 24078031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. AU - Srinivasan,Subramani, AU - Sathish,Gajendren, AU - Jayanthi,Mahadevan, AU - Muthukumaran,Jayachandran, AU - Muruganathan,Udaiyar, AU - Ramachandran,Vinayagam, PY - 2013/06/26/received PY - 2013/09/13/accepted PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/7/6/medline SP - 159 EP - 68 JF - Molecular and cellular biochemistry JO - Mol Cell Biochem VL - 385 IS - 1-2 N2 - Epidemiological studies have demonstrated that diabetes mellitus is a serious health burden for both governments and healthcare providers. This study was hypothesized to evaluate the antihyperglycemic potential of eugenol by determine the activities of key enzymes of glucose metabolism in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg body weight (b.w.)). Eugenol was administered to diabetic rats intragastrically at 2.5, 5, and 10 mg/kg b.w. for 30 days. The dose 10 mg/kg b.w. significantly reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) and increased plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and liver marker enzymes (AST, ALT, and ALP), creatine kinase and blood urea nitrogen in serum and blood of diabetic rats were significantly reverted to near normal levels by the administration of eugenol. Further, eugenol administration to diabetic rats improved body weight and hepatic glycogen content demonstrated the antihyperglycemic potential of eugenol in diabetic rats. The present findings suggest that eugenol can potentially ameliorate key enzymes of glucose metabolism in experimental diabetes, and it is sensible to broaden the scale of use of eugenol in a trial to alleviate the adverse effects of diabetes. SN - 1573-4919 UR - https://www.unboundmedicine.com/medline/citation/24078031/Ameliorating_effect_of_eugenol_on_hyperglycemia_by_attenuating_the_key_enzymes_of_glucose_metabolism_in_streptozotocin_induced_diabetic_rats_ L2 - https://doi.org/10.1007/s11010-013-1824-2 DB - PRIME DP - Unbound Medicine ER -